Determine the necessary mass, volume, or concentration for preparing a solution.
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Synonyms | L-Hydroxyproline | trans-4-Hydroxy-L-proline | hydroxyproline | 51-35-4 | (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid | trans-4-Hydroxyproline | L-4-hydroxyproline | Hypro | hydroxy-L-proline | 4-Hydroxy-L-proline | 4-hydroxyproline | trans-L-Hydroxyproline | (4R)-4-hydroxy-L |
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Specifications & Purity | Moligand™, 10mM in Water |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Product Description | Trans-4-Hydroxy-L-proline is a versatile reagent for the synthesis of neuroexcitatory kainoids and antifungal echinocandins. Also employed in the synthesis of chiral ligands for enantioselective ethylation of aldehydes. trans-4-Hydroxy-L-proline is a natural constituent of animal structural proteins such as collagen and elastin. |
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IUPAC Name | (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid |
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INCHI | InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 |
InChi Key | PMMYEEVYMWASQN-DMTCNVIQSA-N |
Canonical SMILES | C1C(CNC1C(=O)O)O |
Isomeric SMILES | C1[C@H](CN[C@@H]1C(=O)O)O |
WGK Germany | 3 |
PubChem CID | 5810 |
Molecular Weight | 131.13 |
Beilstein | 81441 |
Reaxy-Rn | 471933 |
Enter Lot Number to search for COA:
Sensitivity | Air Sensitive |
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Specific Rotation[α] | -74.0 to -77.0 deg(C=4, H2O) |
Melt Point(°C) | 273°C |
WGK Germany | 3 |
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Reaxy-Rn | 471933 |
Merck Index | 4840 |
1. Hongxian Luo, Gang Li, Longxin Ju, Qiang Lv. (2024) Liquid phase aldol condensation of formaldehyde and propionaldehyde catalyzed by L-proline functional polymers. APPLIED CATALYSIS A-GENERAL, 670 (119545). [PMID:] |
2. Xuexia Xu, Qin Yang, Lanteng Wang, Jie Zheng, Yang Gu, Xiwen Xing, Jiahai Zhou. (2023) Enzymatic hydrolysis of L-azetidine-2-carboxylate ring opening. Catalysis Science & Technology, 13 (13): (3953-3962). [PMID:] |
3. Chen Qin, Fu Xiaomin, Cai Huawei, Fu Shengxiang, Cai Zhongyuan, Li Mufeng, Wu Xiaoai, Tian Rong, Ai Hua. (2023) 68Ga-labeled amphiphilic polymer nanoparticles for PET imaging of sentinel lymph node metastasis. Regenerative Biomaterials, 10 [PMID:37081862] |
4. Yu Zhang, Dekun Cheng, Zhangtie Wang, Yiwen Guo, Ming Chang, Ruijie Liu. (2022) Protective Effect of Orbitides from Linseed (Linum usitatissimum L.) against Ultraviolet B-induced Photoaging in Zebrafish. PHOTOCHEMISTRY AND PHOTOBIOLOGY, [PMID:36484266] |
5. Mingyue Liu, Xiangsheng Wang, Jie Cui, Hongsheng Wang, Binbin Sun, Jufang Zhang, Bernd Rolauffs, Muhammad Shafiq, Xiumei Mo, Zhanyong Zhu, Jinglei Wu. (2023) Electrospun flexible magnesium-doped silica bioactive glass nanofiber membranes with anti-inflammatory and pro-angiogenic effects for infected wounds. Journal of Materials Chemistry B, 11 (2): (359-376). [PMID:36507933] |
6. Mingyue Liu, Weixing Zhang, Zhe Chen, Yangfan Ding, Binbin Sun, Hongsheng Wang, Xiumei Mo, Jinglei Wu. (2022) Mechanisms of magnesium oxide-incorporated electrospun membrane modulating inflammation and accelerating wound healing. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 111 (1): (132-151). [PMID:36205298] |
7. Yangfan Ding, Weixing Zhang, Binbin Sun, Xiumei Mo, Jinglei Wu. (2022) Cyclic freeze–thaw grinding to decellularize meniscus for fabricating porous, elastic scaffolds. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 110 (11): (1824-1839). [PMID:36082975] |
8. Yan Bao, Lu Gao, Feitong Wang, Jianzhong Ma. (2022) Heterocyclic cationic Gemini surfactants for efficient antibacterial, dispersion and fixation. PROCESS SAFETY AND ENVIRONMENTAL PROTECTION, 159 (168). [PMID:] |
1. Hongxian Luo, Gang Li, Longxin Ju, Qiang Lv. (2024) Liquid phase aldol condensation of formaldehyde and propionaldehyde catalyzed by L-proline functional polymers. APPLIED CATALYSIS A-GENERAL, 670 (119545). [PMID:] |
2. Xuexia Xu, Qin Yang, Lanteng Wang, Jie Zheng, Yang Gu, Xiwen Xing, Jiahai Zhou. (2023) Enzymatic hydrolysis of L-azetidine-2-carboxylate ring opening. Catalysis Science & Technology, 13 (13): (3953-3962). [PMID:] |
3. Chen Qin, Fu Xiaomin, Cai Huawei, Fu Shengxiang, Cai Zhongyuan, Li Mufeng, Wu Xiaoai, Tian Rong, Ai Hua. (2023) 68Ga-labeled amphiphilic polymer nanoparticles for PET imaging of sentinel lymph node metastasis. Regenerative Biomaterials, 10 [PMID:37081862] |
4. Yu Zhang, Dekun Cheng, Zhangtie Wang, Yiwen Guo, Ming Chang, Ruijie Liu. (2022) Protective Effect of Orbitides from Linseed (Linum usitatissimum L.) against Ultraviolet B-induced Photoaging in Zebrafish. PHOTOCHEMISTRY AND PHOTOBIOLOGY, [PMID:36484266] |
5. Mingyue Liu, Xiangsheng Wang, Jie Cui, Hongsheng Wang, Binbin Sun, Jufang Zhang, Bernd Rolauffs, Muhammad Shafiq, Xiumei Mo, Zhanyong Zhu, Jinglei Wu. (2023) Electrospun flexible magnesium-doped silica bioactive glass nanofiber membranes with anti-inflammatory and pro-angiogenic effects for infected wounds. Journal of Materials Chemistry B, 11 (2): (359-376). [PMID:36507933] |
6. Mingyue Liu, Weixing Zhang, Zhe Chen, Yangfan Ding, Binbin Sun, Hongsheng Wang, Xiumei Mo, Jinglei Wu. (2022) Mechanisms of magnesium oxide-incorporated electrospun membrane modulating inflammation and accelerating wound healing. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 111 (1): (132-151). [PMID:36205298] |
7. Yangfan Ding, Weixing Zhang, Binbin Sun, Xiumei Mo, Jinglei Wu. (2022) Cyclic freeze–thaw grinding to decellularize meniscus for fabricating porous, elastic scaffolds. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 110 (11): (1824-1839). [PMID:36082975] |
8. Yan Bao, Lu Gao, Feitong Wang, Jianzhong Ma. (2022) Heterocyclic cationic Gemini surfactants for efficient antibacterial, dispersion and fixation. PROCESS SAFETY AND ENVIRONMENTAL PROTECTION, 159 (168). [PMID:] |