trans-4-Hydroxy-L-proline - 10mM in Water, high purity , CAS No.51-35-4

8 Citations
Item Number
T424412
Grouped product items
SKUSizeAvailabilityPrice Qty
T424412-1ml
1ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$69.90

Basic Description

SynonymsL-Hydroxyproline | trans-4-Hydroxy-L-proline | hydroxyproline | 51-35-4 | (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid | trans-4-Hydroxyproline | L-4-hydroxyproline | Hypro | hydroxy-L-proline | 4-Hydroxy-L-proline | 4-hydroxyproline | trans-L-Hydroxyproline | (4R)-4-hydroxy-L
Specifications & PurityMoligand™, 10mM in Water
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
GradeMoligand™
Product Description

Trans-4-Hydroxy-L-proline is a versatile reagent for the synthesis of neuroexcitatory kainoids and antifungal echinocandins. Also employed in the synthesis of chiral ligands for enantioselective ethylation of aldehydes. trans-4-Hydroxy-L-proline is a natural constituent of animal structural proteins such as collagen and elastin.
合成神经兴奋 kainoid 和抗真菌棘白菌素的多功能试剂。也可用于合成手性配体,该配体可用于醛的不对称乙基化。

Associated Targets(Human)

DRD1 Tclin D(1A) dopamine receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ESR1 Tclin Estrogen receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
EGLN1 Tclin Egl nine homolog 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC36A1 Tchem Proton-coupled amino acid transporter 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
VHL Tchem von Hippel-Lindau disease tumor suppressor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HRH3 Tclin Histamine H3 receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HDAC6 Tclin Histone deacetylase 6 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC6A2 Tclin Sodium-dependent noradrenaline transporter (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC6A3 Tclin Sodium-dependent dopamine transporter (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC1A4 Tbio Neutral amino acid transporter A (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC6A4 Tclin Sodium-dependent serotonin transporter (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PGR Tclin Progesterone receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PDE3A Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase A (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PTGS1 Tclin Prostaglandin G/H synthase 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PDE4A Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4A (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC25A20 Tbio Mitochondrial carnitine/acylcarnitine carrier protein (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KDR Tclin Vascular endothelial growth factor receptor 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC1A5 Tchem Neutral amino acid transporter B(0) (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ACHE Tclin Acetylcholinesterase (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC7A10 Tbio Asc-type amino acid transporter 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADRA2A Tclin Alpha-2A adrenergic receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADRA1A Tclin Alpha-1A adrenergic receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
AR Tclin Androgen receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MAOA Tclin Amine oxidase [flavin-containing] A (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HTR1A Tclin 5-hydroxytryptamine receptor 1A (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADORA3 Tchem Adenosine receptor A3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HTR2B Tclin 5-hydroxytryptamine receptor 2B (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TBXA2R Tclin Thromboxane A2 receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
F2 Tclin Prothrombin (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
OPRM1 Tclin Mu-type opioid receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIN3A Tclin Glutamate receptor ionotropic, NMDA 3A (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
F2 Tclin Thrombin (11687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE4A Tclin Phosphodiesterase 4A (1943 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC1A4 Tbio Neutral amino acid transporter A (18 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A498 (42825 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHN (49357 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CAKI-1 (44928 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCRF-CEM (65223 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
COLO 205 (50209 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DU-145 (51482 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HL-60 (67320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-29 (80576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
K562 (73714 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KM12 (47707 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
M14 (47487 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MOLT-4 (49676 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-3 (48710 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-4 (44535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-5 (45555 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-8 (47708 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-3 (62116 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RPMI-8226 (44974 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RXF 393 (41971 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SF-295 (48000 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL-2 (46422 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL-28 (48833 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Slc25a20 Carnitine/acylcarnitine translocase (26 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Grin1 Glutamate NMDA receptor (6467 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slc1a5 Amino acid transporter (271 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slc7a10 Asc-type amino acid transporter 1 (14 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid
INCHI InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
InChi Key PMMYEEVYMWASQN-DMTCNVIQSA-N
Canonical SMILES C1C(CNC1C(=O)O)O
Isomeric SMILES C1[C@H](CN[C@@H]1C(=O)O)O
WGK Germany 3
PubChem CID 5810
Molecular Weight 131.13
Beilstein 81441
Reaxy-Rn 471933

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Chemical and Physical Properties

SensitivityAir Sensitive
Specific Rotation[α]-74.0 to -77.0 deg(C=4, H2O)
Melt Point(°C)273°C

Safety and Hazards(GHS)

WGK Germany 3
Reaxy-Rn 471933
Merck Index 4840

Related Documents

Citations of This Product

1. Hongxian Luo, Gang Li, Longxin Ju, Qiang Lv.  (2024)  Liquid phase aldol condensation of formaldehyde and propionaldehyde catalyzed by L-proline functional polymers.  APPLIED CATALYSIS A-GENERAL,  670  (119545).  [PMID:]
2. Xuexia Xu, Qin Yang, Lanteng Wang, Jie Zheng, Yang Gu, Xiwen Xing, Jiahai Zhou.  (2023)  Enzymatic hydrolysis of L-azetidine-2-carboxylate ring opening.  Catalysis Science & Technology,  13  (13): (3953-3962).  [PMID:]
3. Chen Qin, Fu Xiaomin, Cai Huawei, Fu Shengxiang, Cai Zhongyuan, Li Mufeng, Wu Xiaoai, Tian Rong, Ai Hua.  (2023)  68Ga-labeled amphiphilic polymer nanoparticles for PET imaging of sentinel lymph node metastasis.  Regenerative Biomaterials,  10    [PMID:37081862]
4. Yu Zhang, Dekun Cheng, Zhangtie Wang, Yiwen Guo, Ming Chang, Ruijie Liu.  (2022)  Protective Effect of Orbitides from Linseed (Linum usitatissimum L.) against Ultraviolet B-induced Photoaging in Zebrafish.  PHOTOCHEMISTRY AND PHOTOBIOLOGY,      [PMID:36484266]
5. Mingyue Liu, Xiangsheng Wang, Jie Cui, Hongsheng Wang, Binbin Sun, Jufang Zhang, Bernd Rolauffs, Muhammad Shafiq, Xiumei Mo, Zhanyong Zhu, Jinglei Wu.  (2023)  Electrospun flexible magnesium-doped silica bioactive glass nanofiber membranes with anti-inflammatory and pro-angiogenic effects for infected wounds.  Journal of Materials Chemistry B,  11  (2): (359-376).  [PMID:36507933]
6. Mingyue Liu, Weixing Zhang, Zhe Chen, Yangfan Ding, Binbin Sun, Hongsheng Wang, Xiumei Mo, Jinglei Wu.  (2022)  Mechanisms of magnesium oxide-incorporated electrospun membrane modulating inflammation and accelerating wound healing.  JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,  111  (1): (132-151).  [PMID:36205298]
7. Yangfan Ding, Weixing Zhang, Binbin Sun, Xiumei Mo, Jinglei Wu.  (2022)  Cyclic freeze–thaw grinding to decellularize meniscus for fabricating porous, elastic scaffolds.  JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,  110  (11): (1824-1839).  [PMID:36082975]
8. Yan Bao, Lu Gao, Feitong Wang, Jianzhong Ma.  (2022)  Heterocyclic cationic Gemini surfactants for efficient antibacterial, dispersion and fixation.  PROCESS SAFETY AND ENVIRONMENTAL PROTECTION,  159  (168).  [PMID:]

References

1. Hongxian Luo, Gang Li, Longxin Ju, Qiang Lv.  (2024)  Liquid phase aldol condensation of formaldehyde and propionaldehyde catalyzed by L-proline functional polymers.  APPLIED CATALYSIS A-GENERAL,  670  (119545).  [PMID:]
2. Xuexia Xu, Qin Yang, Lanteng Wang, Jie Zheng, Yang Gu, Xiwen Xing, Jiahai Zhou.  (2023)  Enzymatic hydrolysis of L-azetidine-2-carboxylate ring opening.  Catalysis Science & Technology,  13  (13): (3953-3962).  [PMID:]
3. Chen Qin, Fu Xiaomin, Cai Huawei, Fu Shengxiang, Cai Zhongyuan, Li Mufeng, Wu Xiaoai, Tian Rong, Ai Hua.  (2023)  68Ga-labeled amphiphilic polymer nanoparticles for PET imaging of sentinel lymph node metastasis.  Regenerative Biomaterials,  10    [PMID:37081862]
4. Yu Zhang, Dekun Cheng, Zhangtie Wang, Yiwen Guo, Ming Chang, Ruijie Liu.  (2022)  Protective Effect of Orbitides from Linseed (Linum usitatissimum L.) against Ultraviolet B-induced Photoaging in Zebrafish.  PHOTOCHEMISTRY AND PHOTOBIOLOGY,      [PMID:36484266]
5. Mingyue Liu, Xiangsheng Wang, Jie Cui, Hongsheng Wang, Binbin Sun, Jufang Zhang, Bernd Rolauffs, Muhammad Shafiq, Xiumei Mo, Zhanyong Zhu, Jinglei Wu.  (2023)  Electrospun flexible magnesium-doped silica bioactive glass nanofiber membranes with anti-inflammatory and pro-angiogenic effects for infected wounds.  Journal of Materials Chemistry B,  11  (2): (359-376).  [PMID:36507933]
6. Mingyue Liu, Weixing Zhang, Zhe Chen, Yangfan Ding, Binbin Sun, Hongsheng Wang, Xiumei Mo, Jinglei Wu.  (2022)  Mechanisms of magnesium oxide-incorporated electrospun membrane modulating inflammation and accelerating wound healing.  JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,  111  (1): (132-151).  [PMID:36205298]
7. Yangfan Ding, Weixing Zhang, Binbin Sun, Xiumei Mo, Jinglei Wu.  (2022)  Cyclic freeze–thaw grinding to decellularize meniscus for fabricating porous, elastic scaffolds.  JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,  110  (11): (1824-1839).  [PMID:36082975]
8. Yan Bao, Lu Gao, Feitong Wang, Jianzhong Ma.  (2022)  Heterocyclic cationic Gemini surfactants for efficient antibacterial, dispersion and fixation.  PROCESS SAFETY AND ENVIRONMENTAL PROTECTION,  159  (168).  [PMID:]

Solution Calculators