Tri(1-aziridinyl)phosphine sulfide - 98%, high purity , DNA inhibitor, CAS No.52-24-4, DNA inhibitor

Item Number

T123963

• Synonyms: Thioplex (TN) (Immunex) | Tifosyl | EINECS 200-135-7 | HSDB 3258 | N,N',N''-Triethylenephosphorothioic triamide | Tiotepa | Tris(ethylenimino)thiophosphate | BIDD:GT0127 | MLS001333084 | TESPA | Tespamine | Thio-TEPA, 98%, solid | Spectrum_001689 | Tespam
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: The unstable nitrogen carbon group will alkylate with DNA, resulting in irreversible DNA damage. They prevent tumor growth and directly attack DNA by crosslinking guanine nucleoside in DNA double helix. DNA strands cannot be untied and separated, thus pre
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: DNA inhibitor

Product Description

The unstable nitrogen-carbon groups alkylate with DNA which causes irreversible DNA damage. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. The DNA strands are unable to uncoil and separate which halts cell division.
Thio-TEPA (N,N’N’-triethylenethiophosphoramide) is used as a cancer chemotherapeutic, alkylating agent. It is used to treat various kinds of cancer such as breast, ovarian and bladder cancer. It is also used as conditioning treatment prior to haematopoietic progenitor cell transplantation (HPCT).