Triacsin C from Streptomyces sp. - 94%, high purity , CAS No.76896-80-5

Item Number

T139793

Grouped product items
SKU	Size	Availability	Price
T139793-100μg	100μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$549.90
T139793-500μg	500μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,999.90
T139793-1mg	1mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$2,987.90
T139793-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$9,269.90

Potent, specific acyl-CoA synthetase inhibitor

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Basic Description

Synonyms	2,4,7-Undecatrienal nitrosohydrazone \| WS 1228A;FR 900190 \| 1-Hydroxy-3-(2',4',7'-undecatrienylidine)triazene \| 2,4,7-Undecatrienal, nitrosohydrazone, (E,E,E)- \| (2E,4E,7E)-undecatrienal nitrosohydrazone \| FR-900190 \| (2E,4E,7E)-2,4,7-Undecatrienal nitros
Specifications & Purity	≥94%
Biochemical and Physiological Mechanisms	Triacsin C is a potent inhibitor of long-chain fatty acyl CoA synthetase. It blocks β-cell apoptosis, induced by fatty acids (lipoapoptosis) in a rat model of obesity. In addition, it blocks the de novo synthesis of triglycerides, diglycerides, and choles
Storage Temp	Protected from light,Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Triacsin C, an analog of polyunsaturated fatty acid. A potent vasodilator. Selectively inhibits arachidonoyl-CoA synthetase in intact cells. Inhibits the nonspecific acyl-CoA synthetase in cell sonicates IC50=3.6-8.7 μM1–3. Inhibits neutrophil functions

Names and Identifiers

IUPAC Name	N-[(E)-[(2E,4E,7E)-undeca-2,4,7-trienylidene]amino]nitrous amide
INCHI	InChI=1S/C11H17N3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15/h4-5,7-11H,2-3,6H2,1H3,(H,13,15)/b5-4+,8-7+,10-9+,12-11+
InChi Key	NKTGCVUIESDXPU-YLEPRARLSA-N
Canonical SMILES	CCCC=CCC=CC=CC=NNN=O
Isomeric SMILES	CCC/C=C/C/C=C/C=C/C=N/NN=O
WGK Germany	3
PubChem CID	9576787
Molecular Weight	207.27

Certificates

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8 results found

Lot Number	Certificate Type	Date	Item
J2421751	Certificate of Analysis	Oct 09, 2024	T139793
E2410340	Certificate of Analysis	Apr 11, 2024	T139793
K1908036	Certificate of Analysis	Sep 05, 2023	T139793
K2306130	Certificate of Analysis	Sep 05, 2023	T139793
H2329546	Certificate of Analysis	Aug 17, 2023	T139793
C2209138	Certificate of Analysis	Jan 19, 2022	T139793
C2209139	Certificate of Analysis	Jan 19, 2022	T139793
C2209140	Certificate of Analysis	Jan 19, 2022	T139793

Solubility

Soluble in DMSO (25 mg/ml), and methanol (5 mg/ml).

Sensitivity

Sensitive to light; sensitive to humidity

References

1. Wong A et al.. (2018) Lipid accumulation facilitates mitotic slippage-induced adaptation to anti-mitotic drug treatment.. Cell Death Discov, 4 (109). [PMID:30510774]
2. Pinkosky SL et al.. (2016) Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis.. Nat Commun, 7 (13457). [PMID:27892461]
3. Huawei Xia, Zeming Zhang, Fuping You. (2021) Inhibiting ACSL1-Related Ferroptosis Restrains Murine Coronavirus Infection. Viruses-Basel, 13 (12): (2383). [PMID:34960652] [10.3390/v13122383]

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Basic Description