| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| T129665-1mg | 1mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $68.90 | |
| T129665-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $189.90 | |
| T129665-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $265.90 | |
| T129665-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $529.90 | |
| T129665-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,036.90 |
Potent, selective histone deacetylase inhibitor
| Synonyms | TSA | PD119680 | TRICHOSTATIN A [MI] | trichostatine a | BRD-K68202742-001-05-8 | NCGC_TSA | (2E,4E,6R)-7-(4-Dimethylaminophenyl)-N-hydroxy-4,6-dimethyl-7-oxo-hepta-2,4-dienamide | BDBM50005711 | SR-05000013796-3 | NCGC00162453-01 | [R-(E,E)]-7-[4-(Dimeth |
|---|---|
| Specifications & Purity | Moligand™, ≥98% |
| Biochemical and Physiological Mechanisms | Trichostatin A (TSA) is a potent and non-competitive reversible inhibitor of histone deacetylases (HDAC) with a Ki of 3.4 nM. In HeLa cells, TSA blocked cell cycle progression at G1 and induced a 12-fold increase in intracellular levels of gelsolin. In ce |
| Storage Temp | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Grade | Moligand™ |
| Action Type | INHIBITOR |
| Mechanism of action | Inhibitor of histone deacetylase 1;Inhibitor of histone deacetylase 2;Inhibitor of histone deacetylase 3;Inhibitor of histone deacetylase 4;Inhibitor of histone deacetylase 5;Inhibitor of histone deacetylase 6;Inhibitor of histone deacetylase 7;Inhibitor |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Product Description | Trichostatin A (TSA) is an HDAC inhibitor with IC50 of ~1.8 nM – HDAC8 is the only known member of the HDAC-family that is not affected by TSA. |
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| IUPAC Name | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide |
|---|---|
| INCHI | InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1 |
| InChi Key | RTKIYFITIVXBLE-QEQCGCAPSA-N |
| Canonical SMILES | CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C |
| Isomeric SMILES | C[C@H](/C=C(\C)/C=C/C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C |
| WGK Germany | 3 |
| RTECS | MI5215000 |
| PubChem CID | 444732 |
| Molecular Weight | 302.37 |
| Reaxy-Rn | 2391788 |
Find and download the COA for your product by matching the lot number on the packaging.
18 results found
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 C2527600 | Certificate of Analysis | Jan 13, 2025 | T129665 |
| C2527601 | Certificate of Analysis | Jan 13, 2025 | T129665 |
| C2527602 | Certificate of Analysis | Jan 13, 2025 | T129665 |
| C2527603 | Certificate of Analysis | Jan 13, 2025 | T129665 |
| C2527599 | Certificate of Analysis | Jan 13, 2025 | T129665 |
| E2325553 | Certificate of Analysis | Apr 27, 2023 | T129665 |
| I2420046 | Certificate of Analysis | Apr 27, 2023 | T129665 |
| H2304161 | Certificate of Analysis | Apr 27, 2023 | T129665 |
| E2325550 | Certificate of Analysis | Apr 27, 2023 | T129665 |
| E2325546 | Certificate of Analysis | Apr 27, 2023 | T129665 |
| Solubility | Soluble in water (Partly Miscible), ethanol (2 mg/mL), DMSO (20 mg/mL), acetonitrile, DMF (30 mg/mL), and methanol |
|---|---|
| Sensitivity | Heat sensitive |
| Specific Rotation[α] | 136° (C=0.3,MeOH) |
| Melt Point(°C) | 144 °C(dec.) |
| Molecular Weight | 302.370 g/mol |
| XLogP3 | 2.700 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 6 |
| Exact Mass | 302.163 Da |
| Monoisotopic Mass | 302.163 Da |
| Topological Polar Surface Area | 69.600 Ų |
| Heavy Atom Count | 22 |
| Formal Charge | 0 |
| Complexity | 447.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 2 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 2 |
| Covalently-Bonded Unit Count | 1 |
| Pictogram(s) | GHS07 |
|---|---|
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H317:May cause an allergic skin reaction H312:Harmful in contact with skin H332:Harmful if inhaled |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
| WGK Germany | 3 |
| RTECS | MI5215000 |
| Reaxy-Rn | 2391788 |
| Merck Index | 9649 |
Starting at $355.90
| 1. Pengfei Zhang, Xinyu Chen, Fanqiang Bu, Chen Chen, Lifei Huang, Zixu Xie, Guofeng Li, Xing Wang. (2023) Dual Coordination between Stereochemistry and Cations Endows Polyethylene Terephthalate Fabrics with Diversiform Antimicrobial Abilities for Attack and Defense. ACS Applied Materials & Interfaces, 15 (7): (9926–9939). [PMID:36774642] [10.1021/acsami.2c19323] |
| 2. Rui Li, Li Xie, Lei Li, Xiaojiao Chen, Tong Yao, Yuanxin Tian, Qingping Li, Kai Wang, Chenyang Huang, Cui Li, Yifan Li, Hongwei Zhou, Neil Kaplowitz, Yong Jiang, Peng Chen. (2022) The gut microbial metabolite, 3,4-dihydroxyphenylpropionic acid, alleviates hepatic ischemia/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice. Acta Pharmaceutica Sinica B, 12 (182). [PMID:35127379] [10.1016/j.apsb.2021.05.029] |
| 3. Bo-Yu Peng, Yiming Su, Zhibin Chen, Jiabin Chen, Xuefei Zhou, Mark Eric Benbow, Craig S. Criddle, Wei-Min Wu, Yalei Zhang. (2019) Biodegradation of Polystyrene by Dark (Tenebrio obscurus) and Yellow (Tenebrio molitor) Mealworms (Coleoptera: Tenebrionidae). ENVIRONMENTAL SCIENCE & TECHNOLOGY, 53 (9): (5256–5265). [PMID:30990998] [10.1021/acs.est.8b06963] |
| 4. Yue Xu, Hang Gao, Yan Shen, Shigan Chai, Jinzhi Zhang, Qichao Zou. (2017) Application of Gemini quaternary ammonium with ester groups in cationic P(St-co-BA) nanolatex and study on its antibacterial properties. Materials Science & Engineering C-Materials for Biological Applications, 80 (417). [PMID:28866183] [10.1016/j.msec.2017.06.010] |
| 1. Bradner JE, West N, Grachan ML, Greenberg EF, Haggarty SJ, Warnow T, Mazitschek R. (2010) Chemical phylogenetics of histone deacetylases.. Nat Chem Biol, 6 (3): (238-243). [PMID:20139990] [10.1021/op500134e] |
| 2. Gehring KB et al.. (2016) Involvement of phosphorylated Apis mellifera CREB in gating a honeybee's behavioral response to an external stimulus.. Learn Mem, 23 (5): (195-207). [PMID:27084927] |
| 3. Wang Y et al.. (2019) Dexmedetomidine attenuates the toxicity of ß-amyloid on neurons and astrocytes by increasing BDNF production under the regulation of HDAC2 and HDAC5.. Mol Med Rep, 19 (533-540). [PMID:30483749] |
| 4. Hu JX et al.. (2022) Macrophage migration inhibitory factor (MIF) acetylation protects neurons from ischemic injury.. Cell Death Dis, 13 (5): (466). [PMID:35585040] |
| 5. Pengfei Zhang, Xinyu Chen, Fanqiang Bu, Chen Chen, Lifei Huang, Zixu Xie, Guofeng Li, Xing Wang. (2023) Dual Coordination between Stereochemistry and Cations Endows Polyethylene Terephthalate Fabrics with Diversiform Antimicrobial Abilities for Attack and Defense. ACS Applied Materials & Interfaces, 15 (7): (9926–9939). [PMID:36774642] [10.1021/acsami.2c19323] |
| 6. Rui Li, Li Xie, Lei Li, Xiaojiao Chen, Tong Yao, Yuanxin Tian, Qingping Li, Kai Wang, Chenyang Huang, Cui Li, Yifan Li, Hongwei Zhou, Neil Kaplowitz, Yong Jiang, Peng Chen. (2022) The gut microbial metabolite, 3,4-dihydroxyphenylpropionic acid, alleviates hepatic ischemia/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice. Acta Pharmaceutica Sinica B, 12 (182). [PMID:35127379] [10.1016/j.apsb.2021.05.029] |
| 7. Bo-Yu Peng, Yiming Su, Zhibin Chen, Jiabin Chen, Xuefei Zhou, Mark Eric Benbow, Craig S. Criddle, Wei-Min Wu, Yalei Zhang. (2019) Biodegradation of Polystyrene by Dark (Tenebrio obscurus) and Yellow (Tenebrio molitor) Mealworms (Coleoptera: Tenebrionidae). ENVIRONMENTAL SCIENCE & TECHNOLOGY, 53 (9): (5256–5265). [PMID:30990998] [10.1021/acs.est.8b06963] |
| 8. Yue Xu, Hang Gao, Yan Shen, Shigan Chai, Jinzhi Zhang, Qichao Zou. (2017) Application of Gemini quaternary ammonium with ester groups in cationic P(St-co-BA) nanolatex and study on its antibacterial properties. Materials Science & Engineering C-Materials for Biological Applications, 80 (417). [PMID:28866183] [10.1016/j.msec.2017.06.010] |
