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Trichostatin A - ≥98%, high purity , CAS No.58880-19-6, Inhibitor of histone deacetylase 1;Inhibitor of histone deacetylase 2;Inhibitor of histone deacetylase 3;Inhibitor of histone deacetylase 4;Inhibitor of histone deacetylase 5;Inhibitor of histone deacetylase 6;Inhibitor of histone deacetylase 7;Inhibitor

Moligand™
≥98%

CAS#: 58880-19-6
Formula: C₁₇H₂₂N₂O₃
Molecular Weight: 302.37
MDL number: MFCD03848392
PubChem CID: 444732

Item Number

T129665

Grouped product items
SKU	Size	Availability	Price
T129665-1mg	1mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$68.90
T129665-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$286.90
T129665-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$464.90
T129665-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$929.90
T129665-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,484.90

Potent, selective histone deacetylase inhibitor

View related series

histone deacetylase 1 Inhibitor histone deacetylase 2 Inhibitor histone deacetylase 3 Inhibitor histone deacetylase 4 Inhibitor histone deacetylase 5 Inhibitor histone deacetylase 6 Inhibitor histone deacetylase 7 Inhibitor histone deacetylase 8 Inhibitor histone deacetylase 9 Inhibitor

Basic Description

Synonyms	trichostatin A\|58880-19-6\|TSA\|Trichostatin A (TSA)\|Trichostatin\|(2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide\|Antibiotic A-300\|(R)-Trichostatin A\|CHEBI:46024\|C17H22N2O3\|(R,2E,4E)-7-(4-(dimethylamino)phenyl)-N-hydro
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of histone deacetylase 1;Inhibitor of histone deacetylase 2;Inhibitor of histone deacetylase 3;Inhibitor of histone deacetylase 4;Inhibitor of histone deacetylase 5;Inhibitor of histone deacetylase 6;Inhibitor of histone deacetylase 7;Inhibitor
Product Description	Trichostatin A (TSA) is an HDAC inhibitor with IC50 of ~1.8 nM – HDAC8 is the only known member of the HDAC-family that is not affected by TSA. A potent and non-competitive reversible inhibitor of HDAC.

Associated Targets

HDAC4 Tclin Histone deacetylase 4 1 Activities

Discover Target: HDAC4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 1 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC1 Tclin Histone deacetylase 1 1 Activities

Discover Target: HDAC1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC7 Tclin Histone deacetylase 7 1 Activities

Discover Target: HDAC7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC11 Tclin Histone deacetylase 11 0 Activities

Discover Target: HDAC11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC9 Tclin Histone deacetylase 9 1 Activities

Discover Target: HDAC9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC2 Tclin Histone deacetylase 2 1 Activities

Discover Target: HDAC2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SF3B3 Tchem Splicing factor 3B subunit 3 0 Activities

Discover Target: SF3B3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

F3 Tclin Tissue factor 0 Activities

Discover Target: F3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC10 Tclin Histone deacetylase 10 0 Activities

Discover Target: HDAC10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC8 Tclin Histone deacetylase 8 1 Activities

Discover Target: HDAC8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC5 Tclin Histone deacetylase 5 1 Activities

Discover Target: HDAC5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC3 Tclin Histone deacetylase 3 1 Activities

Discover Target: HDAC3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide
INCHI	InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1
InChi Key	RTKIYFITIVXBLE-QEQCGCAPSA-N
Canonical SMILES	CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
Isomeric SMILES	C[C@H](/C=C(\C)/C=C/C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
WGK Germany	3
RTECS	MI5215000
PubChem CID	444732
Molecular Weight	302.37
Reaxy-Rn	2391788

Database links

DrugBank Ligand	DB04297
PubChem CID	444732
CAS Registry No.	58880-19-6
ChEMBL Ligand	CHEMBL99
Wikipedia	Trichostatin_A
RCSB PDB Ligand	TSN

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

12 results found

Lot Number	Certificate Type	Date	Item
K2212414	Certificate of Analysis	Aug 21, 2024	T129665
E2325536	Certificate of Analysis	Apr 27, 2023	T129665
E2325540	Certificate of Analysis	Apr 27, 2023	T129665
E2325546	Certificate of Analysis	Apr 27, 2023	T129665
E2325550	Certificate of Analysis	Apr 27, 2023	T129665
E2325553	Certificate of Analysis	Apr 27, 2023	T129665
H2304161	Certificate of Analysis	Apr 27, 2023	T129665
H2201090	Certificate of Analysis	Aug 08, 2022	T129665
G2221294	Certificate of Analysis	Jul 23, 2022	T129665
G2405045	Certificate of Analysis	Jun 15, 2022	T129665
K2212408	Certificate of Analysis	Jun 15, 2022	T129665
K2212410	Certificate of Analysis	Jun 15, 2022	T129665

Chemical and Physical Properties

Solubility	Soluble in water (Partly Miscible), ethanol (2 mg/mL), DMSO (20 mg/mL), acetonitrile, DMF (30 mg/mL), and methanol
Sensitivity	Heat sensitive
Specific Rotation[α]	136° (C=0.3,MeOH)
Melt Point(°C)	144 °C(dec.)

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H317:May cause an allergic skin reaction H312:Harmful in contact with skin H332:Harmful if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection.
WGK Germany	3
RTECS	MI5215000
Reaxy-Rn	2391788
Merck Index	9649

References

1. Bradner JE, West N, Grachan ML, Greenberg EF, Haggarty SJ, Warnow T, Mazitschek R. (2010) Chemical phylogenetics of histone deacetylases.. Nat Chem Biol, 6 (3): (238-243). [PMID:20139990]
2. Gehring KB et al.. (2016) Involvement of phosphorylated Apis mellifera CREB in gating a honeybee's behavioral response to an external stimulus.. Learn Mem, 23 (5): (195-207). [PMID:27084927]
3. Wang Y et al.. (2019) Dexmedetomidine attenuates the toxicity of ß-amyloid on neurons and astrocytes by increasing BDNF production under the regulation of HDAC2 and HDAC5.. Mol Med Rep, 19 (533-540). [PMID:30483749]
4. Hu JX et al.. (2022) Macrophage migration inhibitory factor (MIF) acetylation protects neurons from ischemic injury.. Cell Death Dis, 13 (5): (466). [PMID:35585040]

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