Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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T420791-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $91.90 |
Dopamine Receptor Inhibitors
Synonyms | trifluoperazine | Trifluperazine | 117-89-5 | Trifluoroperazine | Trifluoperazin | Flurazine | Triflurin | Triperazine | Trifluoperazina | Trifluoromethylperazine | Trifluoperazinum | Trifluroperizine | Apo-Trifluoperazine | Eskazine | RP 7623 | 10-[3-(4-methylpiperazin-1-yl)propyl]-2 |
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Specifications & Purity | Moligand™, 10mM in DMSO |
Biochemical and Physiological Mechanisms | Trifluoperazine (NSC-17474, RP-7623, SKF-5019) is an FDA-approved antipsychotic drug for schizophrenia. It is an inhibitor of calmodulin (CaM) and Dopamine D2 receptor with an IC50 value of 1.2 nM for D2 receptor. |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Product Description | Information Trifluoperazine Trifluoperazine (NSC-17474, RP-7623, SKF-5019) is an FDA-approved antipsychotic drug for schizophrenia. It is an inhibitor of calmodulin (CaM) and Dopamine D2 receptor with an IC50 value of 1.2 nM for D2 receptor. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine |
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INCHI | InChI=1S/C21H24F3N3S/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24/h2-3,5-8,15H,4,9-14H2,1H3 |
InChi Key | ZEWQUBUPAILYHI-UHFFFAOYSA-N |
Canonical SMILES | CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F |
Isomeric SMILES | CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F |
PubChem CID | 5566 |
Molecular Weight | 407.49 |
Enter Lot Number to search for COA:
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H319:Causes serious eye irritation H317:May cause an allergic skin reaction |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
1. Cen Chen, Yuhang Zhang, Yulong Tang, Guangrong Huang, Han Jiang. (2023) Preparation of magnetic molecularly imprinted polymers for selective extraction of xylazine in milk. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 58 (5): (2599-2608). [PMID:] [10.1111/ijfs.16410] |
2. Shuai Liu, Keming Zheng, Yilin Jiang, Susu Gai, Bohan Li, Dehai Li, Shuang Yang, Zhihua Lv. (2023) Biotransformation of Penindolone, an Influenza A Virus Inhibitor. MOLECULES, 28 (3): (1479). [PMID:36771146] [10.3390/molecules28031479] |
3. Boxuan Yao, Ke Zhang, Xiaoyang Liu, Hua Wei, Zihan Li, Jiarui Zhou, Guangfei Yuan, Xin Wang, Shenghong Yang, Jian Liu. (2023) Versatile preparation strategy of negatively charged saccharide-based polymers for selective removal of cationic organic pollutants. APPLIED SURFACE SCIENCE, 616 (156428). [PMID:] [10.1016/j.apsusc.2023.156428] |
4. Zhihong Yao, Shishi Li, Zifei Qin, Xiaodan Hong, Yi Dai, Baojian Wu, Wencai Ye, Frank J. Gonzalez, Xinsheng Yao. (2017) Characterization of human UDP-glucuronosyltransferases responsible for glucuronidation and inhibition of norbakuchinic acid, a primary metabolite of hepatotoxicity and nephrotoxicity component bakuchiol in Psoralea corylifolia L.. RSC Advances, 7 (83): (52661-52671). [PMID:] [10.1039/C7RA10376J] |
1. Cen Chen, Yuhang Zhang, Yulong Tang, Guangrong Huang, Han Jiang. (2023) Preparation of magnetic molecularly imprinted polymers for selective extraction of xylazine in milk. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 58 (5): (2599-2608). [PMID:] [10.1111/ijfs.16410] |
2. Shuai Liu, Keming Zheng, Yilin Jiang, Susu Gai, Bohan Li, Dehai Li, Shuang Yang, Zhihua Lv. (2023) Biotransformation of Penindolone, an Influenza A Virus Inhibitor. MOLECULES, 28 (3): (1479). [PMID:36771146] [10.3390/molecules28031479] |
3. Boxuan Yao, Ke Zhang, Xiaoyang Liu, Hua Wei, Zihan Li, Jiarui Zhou, Guangfei Yuan, Xin Wang, Shenghong Yang, Jian Liu. (2023) Versatile preparation strategy of negatively charged saccharide-based polymers for selective removal of cationic organic pollutants. APPLIED SURFACE SCIENCE, 616 (156428). [PMID:] [10.1016/j.apsusc.2023.156428] |
4. Zhihong Yao, Shishi Li, Zifei Qin, Xiaodan Hong, Yi Dai, Baojian Wu, Wencai Ye, Frank J. Gonzalez, Xinsheng Yao. (2017) Characterization of human UDP-glucuronosyltransferases responsible for glucuronidation and inhibition of norbakuchinic acid, a primary metabolite of hepatotoxicity and nephrotoxicity component bakuchiol in Psoralea corylifolia L.. RSC Advances, 7 (83): (52661-52671). [PMID:] [10.1039/C7RA10376J] |