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Trifluoperazine Dihydrochloride - >98.0%(HPLC)(T), high purity , Serotonin 2c (5-HT2c) receptor antagonist, CAS No.440-17-5, Serotonin 2c (5-HT2c) receptor antagonist 1 Citations
Cell-permeable calmodulin antagonist
Basic Description Synonyms Trifluoperazine dihydrochloride | 440-17-5 | Trifluoperazine hydrochloride | Stelazine | Trifluoperazine 2HCl | Trifluoperazine HCl | Jatroneural | Terfluzine | Trazine | Triphthazine | Eskazinyl | Triftazin | Tryptazine | Trifluoroperazine hydrochloride | Tryptazine dihydrochloride Specifications & Purity ≥98%(HPLC)(T) Biochemical and Physiological Mechanisms Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.Cell-permeable calmodulin antagonist. Dopamine receptor antagonist. S Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Action Type ANTAGONIST Mechanism of action Serotonin 2c (5-HT2c) receptor antagonist Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. Product Description Trifluoperazine dihydrochloride has been used as a calmodulin kinase antagonist in cultured Aplysia californica neurons. Trifluoperazine dihydrochloride has also been used as a PMCA inhibitor in mouse duodenal tissues to block the transcellular active calcium flux。
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine;dihydrochloride INCHI InChI=1S/C21H24F3N3S.2ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24;;/h2-3,5-8,15H,4,9-14H2,1H3;2*1H InChi Key BXDAOUXDMHXPDI-UHFFFAOYSA-N Canonical SMILES CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F.Cl.Cl Isomeric SMILES CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F.Cl.Cl WGK Germany 3 RTECS SP1750000 PubChem CID 66064 Molecular Weight 480.42 Beilstein 3820020 Reaxy-Rn 3820024
Chemical and Physical Properties Solubility Solubility in water: Completely soluble; Insoluble in Benzene,Ether Sensitivity Heat Sensitive Melt Point(°C) 243°C
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H302: Harmful if swallowed
Precautionary Statements P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P301+P317: IF SWALLOWED: Get medical help.
WGK Germany 3 RTECS SP1750000 Reaxy-Rn 3820024 Merck Index 9680
Citations of This Product 1. Yunfeng Ma, Longxia Li, Liufang Mo, Xiaochen Wang, Chenyue Liu, Yijun Wu, Chaoqun Liu. (2023) Preparation and anti-tumor effects of mesoporous silica nanoparticles loaded with trifluoperazine. Journal of Materials Chemistry B, 11 (43): (10395-10403). [PMID:37876312 ]
References 1. Yunfeng Ma, Longxia Li, Liufang Mo, Xiaochen Wang, Chenyue Liu, Yijun Wu, Chaoqun Liu. (2023) Preparation and anti-tumor effects of mesoporous silica nanoparticles loaded with trifluoperazine. Journal of Materials Chemistry B, 11 (43): (10395-10403). [PMID:37876312 ]
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