| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| T345622-5mg | 5mg | 3 | $31.90 | |
| T345622-25mg | 25mg | 4 | $85.90 | |
| T345622-100mg | 100mg | 2 | $163.90 |
| Synonyms | 1-Methylpyridinio-3-carboxylate | AS-17722 | N-Methylnicotinate | N-methyl-nicotinate | TRIGONELLINE (CONSTITUENT OF FENUGREEK SEED) [DSC] | Caffearin | HY-N0414 | 3-Carboxy-1-methylpyridinium hydroxide inner salt | 3-carboxy-1-methyl-Pyridinium hydroxide |
|---|---|
| Specifications & Purity | ≥98% |
| Storage Temp | Store at 2-8°C,Protected from light |
| Shipped In | Wet ice |
| Product Description | Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis. |
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| Pubchem Sid | 488179910 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179910 |
| IUPAC Name | 1-methylpyridin-1-ium-3-carboxylate |
| INCHI | InChI=1S/C7H7NO2/c1-8-4-2-3-6(5-8)7(9)10/h2-5H,1H3 |
| InChi Key | WWNNZCOKKKDOPX-UHFFFAOYSA-N |
| Canonical SMILES | C[N+]1=CC=CC(=C1)C(=O)[O-] |
| Isomeric SMILES | C[N+]1=CC=CC(=C1)C(=O)[O-] |
| PubChem CID | 5570 |
| Molecular Weight | 137.14 |
Find and download the COA for your product by matching the lot number on the packaging.
13 results found
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 C2512752 | Certificate of Analysis | Mar 01, 2025 | T345622 |
| C2512753 | Certificate of Analysis | Mar 01, 2025 | T345622 |
| C2512754 | Certificate of Analysis | Mar 01, 2025 | T345622 |
| D2426293 | Certificate of Analysis | Apr 18, 2024 | T345622 |
| D2426294 | Certificate of Analysis | Apr 18, 2024 | T345622 |
| D2426296 | Certificate of Analysis | Apr 18, 2024 | T345622 |
| C2405726 | Certificate of Analysis | Feb 04, 2024 | T345622 |
| C2405728 | Certificate of Analysis | Feb 04, 2024 | T345622 |
| C2405729 | Certificate of Analysis | Feb 04, 2024 | T345622 |
| K2228800 | Certificate of Analysis | Sep 24, 2022 | T345622 |
| Sensitivity | Light sensitive |
|---|---|
| Melt Point(°C) | 214-220° C |
| Molecular Weight | 137.140 g/mol |
| XLogP3 | 1.200 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 0 |
| Exact Mass | 137.048 Da |
| Monoisotopic Mass | 137.048 Da |
| Topological Polar Surface Area | 44.000 Ų |
| Heavy Atom Count | 10 |
| Formal Charge | 0 |
| Complexity | 130.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation |
| Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P264:Wash hands [and …] thoroughly after handling. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. |
Starting at $27.90
Starting at $141.90
| 1. Dongsheng Hu, Xiaogang Liu, Yuyue Qin, Jiatong Yan, Rongmei Li, Qiliang Yang. (2023) The impact of different drying methods on the physical properties, bioactive components, antioxidant capacity, volatile components and industrial application of coffee peel. Food Chemistry-X, 19 (100807). [PMID:37780243] [10.1016/j.fochx.2023.100807] |
| 2. Wei Jia, Xin Wang. (2023) 3-Chloropropane-1,2-diol exposure adversely influenced the bio-accessibility signatures of digested infant foods by suppressing the destabilization of α-lactalbumin and d-aspartate oxidase in a dose-dependent manner. FOOD CHEMISTRY, 427 (136729). [PMID:37385056] [10.1016/j.foodchem.2023.136729] |
| 1. Dongsheng Hu, Xiaogang Liu, Yuyue Qin, Jiatong Yan, Rongmei Li, Qiliang Yang. (2023) The impact of different drying methods on the physical properties, bioactive components, antioxidant capacity, volatile components and industrial application of coffee peel. Food Chemistry-X, 19 (100807). [PMID:37780243] [10.1016/j.fochx.2023.100807] |
| 2. Wei Jia, Xin Wang. (2023) 3-Chloropropane-1,2-diol exposure adversely influenced the bio-accessibility signatures of digested infant foods by suppressing the destabilization of α-lactalbumin and d-aspartate oxidase in a dose-dependent manner. FOOD CHEMISTRY, 427 (136729). [PMID:37385056] [10.1016/j.foodchem.2023.136729] |
