Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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T107399-10mg | 10mg | In stock | $180.90 | |
T107399-20mg | 20mg | In stock | $324.90 |
Anti-inflammatory agent with multiple biological activities
Synonyms | HY-32735 | NSC839303 | NSC-839303 | CAS-5611-51-8 | SCHEMBL413634 | MLS000759410 | NCGC00163411-02 | BSPBio_001595 | Triptolid | NCGC00163411-01 | (5bS,6aS,7aS,8R,8aR,9aS,9bS,10aS,10bS)-8-Hydroxy-8a-isopropyl-10b-methyl-1,5,5b,6,6a,8,8a,9a,9b,10b-decahydr |
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Specifications & Purity | analytical standard, ≥98% |
Biochemical and Physiological Mechanisms | Triptolide inhibits cytokine-induced gene expression via inhibition of NF-κB transcriptional activity. Triptolide induces apoptosis in tumor cells by blocking TNF-α mediated c-IAP2 and c-IAP1 (members of the inhibitor of apoptosis family) indu |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | analytical standard |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information . Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (1S,2S,4S,5S,7R,8R,9S,11S,13S)-8-hydroxy-1-methyl-7-propan-2-yl-3,6,10,16-tetraoxaheptacyclo[11.7.0.02,4.02,9.05,7.09,11.014,18]icos-14(18)-en-17-one |
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INCHI | InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1 |
InChi Key | DFBIRQPKNDILPW-CIVMWXNOSA-N |
Canonical SMILES | CC(C)C12C(O1)C3C4(O3)C5(CCC6=C(C5CC7C4(C2O)O7)COC6=O)C |
Isomeric SMILES | CC(C)[C@@]12[C@@H](O1)[C@H]3[C@@]4(O3)[C@]5(CCC6=C([C@@H]5C[C@H]7[C@]4([C@@H]2O)O7)COC6=O)C |
WGK Germany | 3 |
RTECS | YK7751000 |
PubChem CID | 107985 |
Molecular Weight | 360.4 |
Reaxy-Rn | 1692435 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
H23021015 | Certificate of Analysis | Jul 12, 2023 | T107399 |
H23021037 | Certificate of Analysis | Jul 12, 2023 | T107399 |
D2304109 | Certificate of Analysis | Jan 11, 2023 | T107399 |
D2304119 | Certificate of Analysis | Jan 11, 2023 | T107399 |
D2304120 | Certificate of Analysis | Jan 11, 2023 | T107399 |
D2304125 | Certificate of Analysis | Jan 11, 2023 | T107399 |
Melt Point(°C) | 229 °C |
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Pictogram(s) | GHS06, GHS08 |
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Signal | Danger |
Hazard Statements | H301:Toxic if swallowed H300:Fatal if swallowed H330:Fatal if inhaled H300+H330:Fatal if swallowed or if inhaled H361:Suspected of damaging fertility or the unborn child H361f:Suspected of damaging fertility |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P320:Specific treatment is urgent (see ... on this label). P203:Obtain, read and follow all safety instructions before use. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice. P316:Get emergency medical help immediately. |
WGK Germany | 3 |
RTECS | YK7751000 |
Reaxy-Rn | 1692435 |
Merck Index | 9747 |
Starting at $134.90
Starting at $1,235.90
1. Lin Jingpan, Gao Lu, Lin Yanke, Wang Shuai, Yang Zemin, Ren Shujing, Chen Min, Wu Baojian. (2021) Pharmacokinetics-Based Chronoefficacy of Semen Strychni and Tripterygium Glycoside Tablet Against Rheumatoid Arthritis. Frontiers in Pharmacology, 12 [PMID:34108880] |
2. Zhao Huan, Tong Yongbin, Lu Danyi, Wu Baojian. (2020) Circadian clock regulates hepatotoxicity of Tripterygium wilfordii through modulation of metabolism. JOURNAL OF PHARMACY AND PHARMACOLOGY, 72 (12): (1854-1864). [PMID:32478421] |
3. Lin Yanke, Wang Shuai, Zhou Ziyue, Guo Lianxia, Yu Fangjun, Wu Baojian. (2019) Bmal1 regulates circadian expression of cytochrome P450 3a11 and drug metabolism in mice. Communications Biology, 2 (1): (1-11). [PMID:31633069] |
4. Caili Huang, Tao Zeng, Jiawen Li, Lishan Tan, Xiulong Deng, Yanchao Pan, Qi Chen, Aiqing Li, Jianqiang Hu. (2019) Folate Receptor-Mediated Renal-Targeting Nanoplatform for the Specific Delivery of Triptolide to Treat Renal Ischemia/Reperfusion Injury. ACS Biomaterials Science & Engineering, 5 (6): (2877–2886). [PMID:33405591] |
5. Bailing Ma, Mi Lu, Bo-Yang Yu, Jiangwei Tian. (2018) A galactose-mediated targeting nanoprobe for intracellular hydroxyl radical imaging to predict drug-induced liver injury. RSC Advances, 8 (39): (22062-22068). [PMID:35541760] |
1. Zhang H et al.. (2020) DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation.. Cell Rep, 30 (81-97.e7). [PMID:31914400] |
2. Gillen SL et al.. (2021) Differential regulation of mRNA fate by the human Ccr4-Not complex is driven by coding sequence composition and mRNA localization.. Genome Biol, 22 (284). [PMID:34615539] |
3. Lin Jingpan, Gao Lu, Lin Yanke, Wang Shuai, Yang Zemin, Ren Shujing, Chen Min, Wu Baojian. (2021) Pharmacokinetics-Based Chronoefficacy of Semen Strychni and Tripterygium Glycoside Tablet Against Rheumatoid Arthritis. Frontiers in Pharmacology, 12 [PMID:34108880] |
4. Zhao Huan, Tong Yongbin, Lu Danyi, Wu Baojian. (2020) Circadian clock regulates hepatotoxicity of Tripterygium wilfordii through modulation of metabolism. JOURNAL OF PHARMACY AND PHARMACOLOGY, 72 (12): (1854-1864). [PMID:32478421] |
5. Lin Yanke, Wang Shuai, Zhou Ziyue, Guo Lianxia, Yu Fangjun, Wu Baojian. (2019) Bmal1 regulates circadian expression of cytochrome P450 3a11 and drug metabolism in mice. Communications Biology, 2 (1): (1-11). [PMID:31633069] |
6. Caili Huang, Tao Zeng, Jiawen Li, Lishan Tan, Xiulong Deng, Yanchao Pan, Qi Chen, Aiqing Li, Jianqiang Hu. (2019) Folate Receptor-Mediated Renal-Targeting Nanoplatform for the Specific Delivery of Triptolide to Treat Renal Ischemia/Reperfusion Injury. ACS Biomaterials Science & Engineering, 5 (6): (2877–2886). [PMID:33405591] |
7. Bailing Ma, Mi Lu, Bo-Yang Yu, Jiangwei Tian. (2018) A galactose-mediated targeting nanoprobe for intracellular hydroxyl radical imaging to predict drug-induced liver injury. RSC Advances, 8 (39): (22062-22068). [PMID:35541760] |