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Tris(hydroxymethyl)aminomethane - Primary Standard and Buffer, ≥99.9% (titration), high purity , CAS No.77-86-1

  • ≥99.9%(T)
  • Primary Standard and Buffer
Item Number
T110599
Grouped product items
SKUSizeAvailabilityPrice Qty
T110599-100g
100g
In stock
$29.90
T110599-500g
500g
In stock
$81.90

Proton acceptor

Basic Description

SynonymsTrometamol|TROMETHAMINE|77-86-1|Tris(Hydroxymethyl)aminomethane|Tris|2-Amino-2-(hydroxymethyl)propane-1,3-diol|Tham|Trisamine|Trizma|Tris base|2-Amino-2-(hydroxymethyl)-1,3-propanediol|Tris buffer|Tromethane|Tris-base|Trisaminol|Pehanorm|Talatrol|Trisamin
Specifications & Purity≥99.9%(T), Primary Standard and Buffer
Biochemical and Physiological MechanismsProton acceptor (pKa = 8.07 at 25 °C). Shows diuretic effects in vivo via osmosis . Orally active.
Storage TempArgon charged
Shipped InNormal
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets

CTH Tchem Cystathionine gamma-lyase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CNR1 Tclin Cannabinoid receptor 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

DRD2 Tclin D(2) dopamine receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

DRD4 Tchem D(4) dopamine receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ERBB2 Tclin Receptor tyrosine-protein kinase erbB-2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ELANE Tclin Neutrophil elastase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

EGFR Tclin Epidermal growth factor receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AVPR1A Tclin Vasopressin V1a receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HMGCR Tclin 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HRH1 Tclin Histamine H1 receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC6A3 Tclin Sodium-dependent dopamine transporter 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC6A4 Tclin Sodium-dependent serotonin transporter 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SIGMAR1 Tclin Sigma non-opioid intracellular receptor 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA2 Tclin Carbonic anhydrase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

DRD3 Tclin D(3) dopamine receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FLT1 Tclin Vascular endothelial growth factor receptor 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CHRM3 Tclin Muscarinic acetylcholine receptor M3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CHRM4 Tclin Muscarinic acetylcholine receptor M4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADRA2B Tclin Alpha-2B adrenergic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADRA2C Tclin Alpha-2C adrenergic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HTR2A Tclin 5-hydroxytryptamine receptor 2A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADORA2A Tclin Adenosine receptor A2a 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ACHE Tclin Acetylcholinesterase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADRA1B Tclin Alpha-1B adrenergic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADRB1 Tclin Beta-1 adrenergic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADRA1A Tclin Alpha-1A adrenergic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AR Tclin Androgen receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAOA Tclin Amine oxidase [flavin-containing] A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AKR1B1 Tclin Aldose reductase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADORA1 Tclin Adenosine receptor A1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HTR1A Tclin 5-hydroxytryptamine receptor 1A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADORA3 Tchem Adenosine receptor A3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HTR6 Tchem 5-hydroxytryptamine receptor 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HTR2B Tclin 5-hydroxytryptamine receptor 2B 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

EDNRA Tclin Endothelin-1 receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

OPRD1 Tclin Delta-type opioid receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

OPRK1 Tclin Kappa-type opioid receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

OPRM1 Tclin Mu-type opioid receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NOS2 Tchem Nitric oxide synthase, inducible 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TACR1 Tclin Substance-P receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NOS1 Tchem Nitric oxide synthase, brain 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 2-amino-2-(hydroxymethyl)propane-1,3-diol
INCHI InChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
InChi Key LENZDBCJOHFCAS-UHFFFAOYSA-N
Canonical SMILES C(C(CO)(CO)N)O
Isomeric SMILES C(C(CO)(CO)N)O
WGK Germany 2
RTECS TY2900000
PubChem CID 6503
Molecular Weight 121.14
Beilstein 741883

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

71 results found

Lot NumberCertificate TypeDateItem
F2412375Certificate of AnalysisJun 15, 2024 T110599
F2412374Certificate of AnalysisJun 15, 2024 T110599
F2412373Certificate of AnalysisJun 15, 2024 T110599
E2424094Certificate of AnalysisMay 27, 2024 T110599
E2424089Certificate of AnalysisMay 27, 2024 T110599
E2424086Certificate of AnalysisMay 27, 2024 T110599
E2424087Certificate of AnalysisMay 25, 2024 T110599
C2428100Certificate of AnalysisApr 03, 2024 T110599
C2428097Certificate of AnalysisApr 02, 2024 T110599
C2428098Certificate of AnalysisApr 02, 2024 T110599
C2428099Certificate of AnalysisApr 02, 2024 T110599
E2420049Certificate of AnalysisApr 02, 2024 T110599
C2425527Certificate of AnalysisMar 28, 2024 T110599
B2421325Certificate of AnalysisMar 06, 2024 T110599
B2421329Certificate of AnalysisMar 06, 2024 T110599
B2421327Certificate of AnalysisFeb 27, 2024 T110599
B2421326Certificate of AnalysisFeb 27, 2024 T110599
A2403302Certificate of AnalysisJan 20, 2024 T110599
A2403342Certificate of AnalysisJan 20, 2024 T110599
L2305166Certificate of AnalysisDec 15, 2023 T110599
K2307123Certificate of AnalysisNov 17, 2023 T110599
K2307122Certificate of AnalysisNov 17, 2023 T110599
K2307171Certificate of AnalysisNov 17, 2023 T110599
K2307120Certificate of AnalysisNov 16, 2023 T110599
H2312199Certificate of AnalysisSep 02, 2023 T110599
H2321718Certificate of AnalysisSep 02, 2023 T110599
H2321720Certificate of AnalysisSep 02, 2023 T110599
H2321717Certificate of AnalysisSep 02, 2023 T110599
H2312198Certificate of AnalysisAug 31, 2023 T110599
H2312227Certificate of AnalysisAug 23, 2023 T110599
G2327310Certificate of AnalysisAug 09, 2023 T110599
G2324174Certificate of AnalysisAug 02, 2023 T110599
G2324172Certificate of AnalysisAug 02, 2023 T110599
G2324164Certificate of AnalysisAug 02, 2023 T110599
G2324159Certificate of AnalysisAug 02, 2023 T110599
E2329875Certificate of AnalysisJun 02, 2023 T110599
E23081271Certificate of AnalysisMay 17, 2023 T110599
B2324850Certificate of AnalysisMar 09, 2023 T110599
B2324811Certificate of AnalysisMar 01, 2023 T110599
B2324810Certificate of AnalysisMar 01, 2023 T110599
L2228075Certificate of AnalysisJan 04, 2023 T110599
L2228061Certificate of AnalysisDec 30, 2022 T110599
L2228062Certificate of AnalysisDec 30, 2022 T110599
L2228064Certificate of AnalysisDec 30, 2022 T110599
L2228074Certificate of AnalysisDec 30, 2022 T110599
J2227775Certificate of AnalysisOct 31, 2022 T110599
J2227778Certificate of AnalysisOct 31, 2022 T110599
J2227773Certificate of AnalysisOct 29, 2022 T110599
H2206051Certificate of AnalysisAug 11, 2022 T110599
H2206053Certificate of AnalysisAug 11, 2022 T110599
H2206055Certificate of AnalysisAug 11, 2022 T110599
F2206475Certificate of AnalysisJun 10, 2022 T110599
F2206395Certificate of AnalysisJun 10, 2022 T110599
H2206052Certificate of AnalysisJun 10, 2022 T110599
E2218244Certificate of AnalysisMay 20, 2022 T110599
E2209015Certificate of AnalysisMay 10, 2022 T110599
C2224231Certificate of AnalysisApr 01, 2022 T110599
H2206054Certificate of AnalysisApr 01, 2022 T110599
F2206403Certificate of AnalysisApr 01, 2022 T110599
F2206402Certificate of AnalysisApr 01, 2022 T110599
C2224559Certificate of AnalysisApr 01, 2022 T110599
C2219593Certificate of AnalysisMar 30, 2022 T110599
C2219594Certificate of AnalysisMar 30, 2022 T110599
C2219595Certificate of AnalysisMar 30, 2022 T110599
C2219596Certificate of AnalysisMar 30, 2022 T110599
C2219597Certificate of AnalysisMar 30, 2022 T110599
B2218556Certificate of AnalysisFeb 23, 2022 T110599
B2218530Certificate of AnalysisFeb 22, 2022 T110599
B2218537Certificate of AnalysisFeb 22, 2022 T110599
B2218546Certificate of AnalysisFeb 22, 2022 T110599
B2218518Certificate of AnalysisFeb 22, 2022 T110599

more

Chemical and Physical Properties

SensitivityMoisture sensitive.
Boil Point(°C)219-220 °C/10 mmHg (lit.)
Melt Point(°C)167-172 °C (lit.)

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 2
RTECS TY2900000

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References

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