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Troglitazone - ≥96%, high purity , CAS No.97322-87-7, Agonist of Peroxisome proliferator-activated receptor-γ;Channel blocker of TRPM3

Moligand™
≥96%

CAS#: 97322-87-7
Formula: C₂₄H₂₇NO₅S
Molecular Weight: 441.54
MDL number: MFCD00878416
PubChem CID: 5591

Item Number

T126362

Grouped product items
SKU	Size	Availability	Price
T126362-10mg	10mg	In stock	$109.90
T126362-50mg	50mg	In stock	$385.90
T126362-100mg	100mg	In stock	$701.90

Potent, selective PPAR-γ receptor agonist

View related series

Peroxisome proliferator-activated receptor-γ Agonist TRPM3 Channel blocker

Basic Description

Synonyms	troglitazone\|97322-87-7\|Rezulin\|Romglizone\|Prelay\|CS-045\|Romozin\|Noscal\|Rezulin (TN)\|troglitazona\|troglitazonum\|CS 045\|GR 92132X\|CCRIS 8969\|GR92132X\|CI 991\|CI-991\|GR-92132X\|CHEBI:9753\|5-(4-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl)thiazolid
Specifications & Purity	≥96%
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST, CHANNEL BLOCKER
Mechanism of action	Agonist of Peroxisome proliferator-activated receptor-γ;Channel blocker of TRPM3
Product Description	Troglitazone(CS-045), PPARγ agonist, is an anti-diabetic thiazolidinedione (TZD) with anti-inflammatory and anti-tumor activity. A potent antiproliferative, apoptosis inducer, antioxidant, and antiinflammatory agent

Associated Targets

TRPM3 Tchem Transient receptor potential cation channel subfamily M member 3 0 Activities

Discover Target: TRPM3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FOXM1 Tchem Forkhead box protein M1 1 Activities

Discover Target: FOXM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CA2 Tclin Carbonic anhydrase 2 1 Activities

Discover Target: CA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PPARG Tclin Peroxisome proliferator-activated receptor gamma 2 Activities

Discover Target: PPARG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
INCHI	InChI=1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28)
InChi Key	GXPHKUHSUJUWKP-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C2=C(CCC(O2)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C(=C1O)C)C
Isomeric SMILES	CC1=C(C2=C(CCC(O2)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C(=C1O)C)C
PubChem CID	5591
Molecular Weight	441.54

PubChem CID

ChEBI

CAS Registry No.

ChEMBL Ligand

DrugBank Ligand

BindingDB Ligand

Wikipedia

NURSA Ligand

DrugCentral Ligand

Certificates

Certificate of Analysis(COA)

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8 results found

Lot Number	Certificate Type	Date	Item
H2416039	Certificate of Analysis	Aug 22, 2024	T126362
J2212284	Certificate of Analysis	Jul 08, 2024	T126362
J2212286	Certificate of Analysis	Jul 08, 2024	T126362
J2212290	Certificate of Analysis	Jul 08, 2024	T126362
H1725059	Certificate of Analysis	Feb 07, 2023	T126362
G2214241	Certificate of Analysis	Jun 01, 2022	T126362
G2214246	Certificate of Analysis	Jun 01, 2022	T126362
G2214447	Certificate of Analysis	Jun 01, 2022	T126362

Solubility

Soluble in ethanol (>25 mg/ml) at 50 °C, DMSO (>25 mg/ml), DMF (30 mg/ml), DMSO:PBS (1:6, pH 7.2) (0.1 mg/ml), and water (0.1 mg/ml) at 25 °C.

Sensitivity

Air Sensitive,Heat Sensitive

Melt Point(°C)

177 °C

References

1. Pinkosky SL et al.. (2016) Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis.. Nat Commun, 7 (13457). [PMID:27892461]
2. Zhu HY et al.. (2016) Peroxisome proliferator-activated receptor-? agonist inhibits collagen synthesis in human keloid fibroblasts by suppression of early growth response-1 expression through upregulation of miR-543 expression.. Am J Cancer Res, 6 (6): (1358-70). [PMID:27429849]
3. Zhu HY et al.. (2016) Peroxisome proliferator-activated receptor-? agonist troglitazone suppresses transforming growth factor-ß1 signalling through miR-92b upregulation-inhibited Axl expression in human keloid fibroblasts in vitro.. Am J Transl Res, 8 (8): (3460-70). [PMID:27648136]

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