Troglitazone - ≥96%, high purity , CAS No.97322-87-7, Agonist of Peroxisome proliferator-activated receptor-γ;Channel blocker of TRPM3

1 Citations
Item Number
T126362
Grouped product items
SKUSizeAvailabilityPrice Qty
T126362-10mg
10mg
In stock
$109.90
T126362-50mg
50mg
In stock
$385.90
T126362-100mg
100mg
In stock
$701.90

Potent, selective PPAR-γ receptor agonist

Basic Description

SynonymsCS045 | CS-045 | HSCI1_000037 | DTXSID8023719 | Q7844989 | Rezulin (TN) | SR-05000000454-5 | 5-[(4-{[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methyl]oxy}phenyl)methyl]-1,3-thiazolidine-2,4-dione | AB00643330-02 | Troglitazone (JAN/USAN/I
Specifications & PurityMoligand™, ≥96%
Biochemical and Physiological MechanismsTroglitazone has been shown to be a potent antiproliferative and apoptosis inducer. This compound has displayed a capacity to inhibit growth of HCC cells via G1 phase cell cycle arrest through hypophosphorylation of Rb (retinoblastoma) protein and an incr
Storage TempStore at -20°C,Argon charged
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST, CHANNEL BLOCKER
Mechanism of actionAgonist of Peroxisome proliferator-activated receptor-γ;Channel blocker of TRPM3
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Troglitazone(CS-045), PPARγ agonist, is an anti-diabetic thiazolidinedione (TZD) with anti-inflammatory and anti-tumor activity.
A potent antiproliferative, apoptosis inducer, antioxidant, and antiinflammatory agent

Associated Targets(Human)

TRPM3 Tchem Transient receptor potential cation channel subfamily M member 3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FOXM1 Tchem Forkhead box protein M1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CA2 Tclin Carbonic anhydrase 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PPARG Tclin Peroxisome proliferator-activated receptor gamma (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
INCHI InChI=1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28)
InChi Key GXPHKUHSUJUWKP-UHFFFAOYSA-N
Canonical SMILES CC1=C(C2=C(CCC(O2)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C(=C1O)C)C
Isomeric SMILES CC1=C(C2=C(CCC(O2)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C(=C1O)C)C
PubChem CID 5591
Molecular Weight 441.54

Certificates

Certificate of Analysis(COA)

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8 results found

Lot NumberCertificate TypeDateItem
H2416039Certificate of AnalysisAug 22, 2024 T126362
J2212284Certificate of AnalysisJul 08, 2024 T126362
J2212286Certificate of AnalysisJul 08, 2024 T126362
J2212290Certificate of AnalysisJul 08, 2024 T126362
H1725059Certificate of AnalysisFeb 07, 2023 T126362
G2214241Certificate of AnalysisJun 01, 2022 T126362
G2214246Certificate of AnalysisJun 01, 2022 T126362
G2214447Certificate of AnalysisJun 01, 2022 T126362

Chemical and Physical Properties

SolubilitySoluble in ethanol (>25 mg/ml) at 50 °C, DMSO (>25 mg/ml), DMF (30 mg/ml), DMSO:PBS (1:6, pH 7.2) (0.1 mg/ml), and water (0.1 mg/ml) at 25 °C.
SensitivityAir Sensitive,Heat Sensitive
Melt Point(°C)177 °C

Safety and Hazards(GHS)

Merck Index 9769

Related Documents

Citations of This Product

1. Shuai Liu, Keming Zheng, Yilin Jiang, Susu Gai, Bohan Li, Dehai Li, Shuang Yang, Zhihua Lv.  (2023)  Biotransformation of Penindolone, an Influenza A Virus Inhibitor.  MOLECULES,  28  (3): (1479).  [PMID:36771146]

References

1. Pinkosky SL et al..  (2016)  Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis..  Nat Commun,  (13457).  [PMID:27892461]
2. Zhu HY et al..  (2016)  Peroxisome proliferator-activated receptor-? agonist inhibits collagen synthesis in human keloid fibroblasts by suppression of early growth response-1 expression through upregulation of miR-543 expression..  Am J Cancer Res,  (6): (1358-70).  [PMID:27429849]
3. Zhu HY et al..  (2016)  Peroxisome proliferator-activated receptor-? agonist troglitazone suppresses transforming growth factor-ß1 signalling through miR-92b upregulation-inhibited Axl expression in human keloid fibroblasts in vitro..  Am J Transl Res,  (8): (3460-70).  [PMID:27648136]
4. Shuai Liu, Keming Zheng, Yilin Jiang, Susu Gai, Bohan Li, Dehai Li, Shuang Yang, Zhihua Lv.  (2023)  Biotransformation of Penindolone, an Influenza A Virus Inhibitor.  MOLECULES,  28  (3): (1479).  [PMID:36771146]

Solution Calculators