Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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T112998-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $24.90 | |
T112998-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $73.90 | |
T112998-10g | 10g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $131.90 | |
T112998-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $248.90 | |
T112998-100g | 100g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $896.90 | |
T112998-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $4,032.90 |
Synonyms | 2-Hydroxy-2,4,6-cycloheptatrienone | CCRIS 6609 | DTXSID8049416 | NCGC00260470-01 | 2-hydroxy-2,4,6-cycloheptatrien -1-one | SCHEMBL42739 | MFCD00004158 | AC1614 | Tropolone, purum, >=98.0% (GC) | 2,4,6-Cycloheptatrien-1-one, 2-hydroxy- | (2E,4Z,6Z)-2-hyd |
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Specifications & Purity | ≥98% |
Storage Temp | Store at 2-8°C,Argon charged |
Shipped In | Wet ice |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 2-hydroxycyclohepta-2,4,6-trien-1-one |
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INCHI | InChI=1S/C7H6O2/c8-6-4-2-1-3-5-7(6)9/h1-5H,(H,8,9) |
InChi Key | MDYOLVRUBBJPFM-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C(C(=O)C=C1)O |
Isomeric SMILES | C1=CC=C(C(=O)C=C1)O |
WGK Germany | 3 |
RTECS | GU4075000 |
PubChem CID | 10789 |
Molecular Weight | 122.12 |
Beilstein | 1904978 |
Reaxy-Rn | 1904978 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
I2402080 | Certificate of Analysis | Jul 13, 2024 | T112998 |
I2402010 | Certificate of Analysis | Jul 13, 2024 | T112998 |
F2215497 | Certificate of Analysis | Mar 18, 2024 | T112998 |
F2215498 | Certificate of Analysis | Mar 18, 2024 | T112998 |
F2215499 | Certificate of Analysis | Mar 18, 2024 | T112998 |
F2215595 | Certificate of Analysis | Mar 18, 2024 | T112998 |
L2125213 | Certificate of Analysis | Sep 22, 2023 | T112998 |
L2125231 | Certificate of Analysis | Sep 22, 2023 | T112998 |
F2413077 | Certificate of Analysis | Nov 29, 2022 | T112998 |
L22161019 | Certificate of Analysis | Nov 29, 2022 | T112998 |
L22161035 | Certificate of Analysis | Nov 29, 2022 | T112998 |
L22161040 | Certificate of Analysis | Nov 29, 2022 | T112998 |
L22161049 | Certificate of Analysis | Nov 29, 2022 | T112998 |
L22161051 | Certificate of Analysis | Nov 29, 2022 | T112998 |
L22161052 | Certificate of Analysis | Nov 29, 2022 | T112998 |
Solubility | Soluble in water. |
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Sensitivity | heat sensitive&Moisture sensitive. |
Flash Point(°F) | 233.6 °F |
Flash Point(°C) | 112 °C |
Boil Point(°C) | 80-84°C |
Melt Point(°C) | 50-52°C |
Pictogram(s) | GHS09, GHS05, GHS07 |
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Signal | Danger |
Hazard Statements | H314:Causes severe skin burns and eye damage H318:Causes serious eye damage H317:May cause an allergic skin reaction H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P363:Wash contaminated clothing before reuse. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. P302+P361+P354:IF ON SKIN: Take off Immediately all contaminated clothing. Immediately rinse with water for several minutes. P316:Get emergency medical help immediately. |
WGK Germany | 3 |
RTECS | GU4075000 |
Reaxy-Rn | 1904978 |
Starting at $69.90
Starting at $12.90
1. Xueyang Jin, Ming Zhang, Jinghui Lu, Ximeng Duan, Jinyao Chen, Yue Liu, Wenqiang Chang, Hongxiang Lou. (2021) Hinokitiol chelates intracellular iron to retard fungal growth by disturbing mitochondrial respiration. Journal of Advanced Research, 34 (65). [PMID:35024181] [10.1016/j.jare.2021.06.016] |
2. Junyong Sun, Han Mei, Sufan Wang, Feng Gao. (2016) Two-Photon Semiconducting Polymer Dots with Dual-Emission for Ratiometric Fluorescent Sensing and Bioimaging of Tyrosinase Activity. ANALYTICAL CHEMISTRY, 88 (14): (7372–7377). [PMID:27322725] [10.1021/acs.analchem.6b01929] |
1. Jinbing Liu,Wei Yi,Yiqian Wan,Lin Ma,Huacan Song. (2008-03-08) 1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors.. Bioorganic & medicinal chemistry, 16 ((3)): (1096-1102). [PMID:18326070] |
2. Jinbing Liu,Rihui Cao,Wei Yi,Chunming Ma,Yiqian Wan,Binhua Zhou,Lin Ma,Huacan Song. (2008-06-06) A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds.. European journal of medicinal chemistry, 44 ((4)): (1773-1778). [PMID:18524420] |
3. Donald D Nolting,Michael Nickels,Ronald Price,John C Gore,Wellington Pham. (2009-07-21) Synthesis of bicyclo[5.3.0]azulene derivatives.. Nature protocols, 4 ((8)): (1113-1117). [PMID:19617883] |
4. Wei Yi,Rihui Cao,Huan Wen,Qin Yan,Binhua Zhou,Lin Ma,Huacan Song. (2009-10-06) Discovery of 4-functionalized phenyl-O-beta-D-glycosides as a new class of mushroom tyrosinase inhibitors.. Bioorganic & medicinal chemistry letters, 19 ((21)): (6157-6160). [PMID:19800229] |
5. Maria Koufaki,Elissavet Theodorou,Xanthippi Alexi,Faidra Nikoloudaki,Michael N Alexis. (2010-01-05) Synthesis of tropolone derivatives and evaluation of their in vitro neuroprotective activity.. European journal of medicinal chemistry, 45 ((3)): (1107-1112). [PMID:20045220] |
6. Jennifer A Jacobsen,Jessica L Fullagar,Melissa T Miller,Seth M Cohen. (2010-12-30) Identifying chelators for metalloprotein inhibitors using a fragment-based approach.. Journal of medicinal chemistry, 54 ((2)): (591-602). [PMID:21189019] |
7. Anahit Penesyan,Jan Tebben,Matthew Lee,Torsten Thomas,Staffan Kjelleberg,Tilmann Harder,Suhelen Egan. (2011-09-06) Identification of the antibacterial compound produced by the marine epiphytic bacterium Pseudovibrio sp. D323 and related sponge-associated bacteria.. Marine drugs, 9 ((8)): (1391-1402). [PMID:21892353] |
8. Mohammad R Seyedsayamdost,Gavin Carr,Roberto Kolter,Jon Clardy. (2011-09-21) Roseobacticides: small molecule modulators of an algal-bacterial symbiosis.. Journal of the American Chemical Society, 133 ((45)): (18343-18349). [PMID:21928816] |
9. Martine Berger,Alexander Neumann,Stefan Schulz,Meinhard Simon,Thorsten Brinkhoff. (2011-09-29) Tropodithietic acid production in Phaeobacter gallaeciensis is regulated by N-acyl homoserine lactone-mediated quorum sensing.. Journal of bacteriology, 193 ((23)): (6576-6585). [PMID:21949069] |
10. Mayumi Kaneko,Daisuke Matsuda,Masaki Ohtawa,Takashi Fukuda,Tohru Nagamitsu,Takao Yamori,Hiroshi Tomoda. (2012-01-10) Potentiation of bleomycin in Jurkat cells by fungal pycnidione.. Biological & pharmaceutical bulletin, 35 ((1)): (18-28). [PMID:22223332] |
11. Junichiro Ishii,Hiroshi Omura,Tadao Mitsui,Norichika Eguchi,Takashi Ueno,Hisaya Goto,Hiroshi Ito. (2012-01-19) Effects of a combination of hinokitiol (β-thujaplicin) and an organic acid mixture on ruminal fermentation in heifers fed a high-grain diet.. Animal science journal = Nihon chikusan Gakkaiho, 83 ((1)): (36-42). [PMID:22250737] |
12. Martine Berger,Nelson L Brock,Heiko Liesegang,Marco Dogs,Ines Preuth,Meinhard Simon,Jeroen S Dickschat,Thorsten Brinkhoff. (2012-03-13) Genetic analysis of the upper phenylacetate catabolic pathway in the production of tropodithietic acid by Phaeobacter gallaeciensis.. Applied and environmental microbiology, 78 ((10)): (3539-3551). [PMID:22407685] |
13. Jong Yuh Cherng,Li Yin Chen,Mei Fen Shih. (2012-03-16) Preventive effects of β-thujaplicin against UVB-induced MMP-1 and MMP-3 mRNA expressions in skin fibroblasts.. The American journal of Chinese medicine, 40 ((2)): (387-398). [PMID:22419431] |
14. M-F Shih,L-Y Chen,P-J Tsai,J-Y Cherng. (2012-04-18) In vitro and in vivo therapeutics of β-thujaplicin on LPS-induced inflammation in macrophages and septic shock in mice.. International journal of immunopathology and pharmacology, 25 ((1)): (39-48). [PMID:22507316] |
15. Jack Davison,Ahmed al Fahad,Menghao Cai,Zhongshu Song,Samar Y Yehia,Colin M Lazarus,Andrew M Bailey,Thomas J Simpson,Russell J Cox. (2012-04-18) Genetic, molecular, and biochemical basis of fungal tropolone biosynthesis.. Proceedings of the National Academy of Sciences of the United States of America, 109 ((20)): (7642-7647). [PMID:22508998] |
16. Jason M Crawford,Jon Clardy. (2012-05-03) Microbial genome mining answers longstanding biosynthetic questions.. Proceedings of the National Academy of Sciences of the United States of America, 109 ((20)): (7589-7590). [PMID:22550177] |
17. Tomasz Borowski,Anna Wójcik,Anna Miłaczewska,Valentin Georgiev,Margareta R A Blomberg,Per E M Siegbahn. (2012-05-25) The alkenyl migration mechanism catalyzed by extradiol dioxygenases: a hybrid DFT study.. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 17 ((6)): (881-890). [PMID:22622485] |
18. Sebastian Thole,Daniela Kalhoefer,Sonja Voget,Martine Berger,Tim Engelhardt,Heiko Liesegang,Antje Wollherr,Staffan Kjelleberg,Rolf Daniel,Meinhard Simon,Torsten Thomas,Thorsten Brinkhoff. (2012-06-22) Phaeobacter gallaeciensis genomes from globally opposite locations reveal high similarity of adaptation to surface life.. The ISME journal, 6 ((12)): (2229-2244). [PMID:22717884] |
19. Jamie Wright,William McCaskill Clark,Jennifer A Cain,Alan Patterson,Christopher J Coates,Jacqueline Nairn. (2012-08-14) Effects of known phenoloxidase inhibitors on hemocyanin-derived phenoloxidase from Limulus polyphemus.. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 163 ((3-4)): (303-308). [PMID:22885403] |
20. Katsuhisa Kurogi,Adnan Alazizi,Ming-Yih Liu,Yoichi Sakakibara,Masahito Suiko,Takuya Sugahara,Ming-Cheh Liu. (2012-08-25) Concerted actions of the catechol O-methyltransferase and the cytosolic sulfotransferase SULT1A3 in the metabolism of catecholic drugs.. Biochemical pharmacology, 84 ((9)): (1186-1195). [PMID:22917559] |
21. E Zachary Oblak,Erin S D Bolstad,Sophia N Ononye,Nigel D Priestley,M Kyle Hadden,Dennis L Wright. (2012-10-04) The furan route to tropolones: probing the antiproliferative effects of β-thujaplicin analogs.. Organic & biomolecular chemistry, 10 ((43)): (8597-8604). [PMID:23032214] |
22. Ryuichi Fujisaki,Kiyoko Kamei,Mariko Yamamura,Hajime Nishiya,Shigeharu Inouye,Miki Takahashi,Shigeru Abe. (2012-10-23) In vitro and in vivo anti-plasmodial activity of essential oils, including hinokitiol.. The Southeast Asian journal of tropical medicine and public health, 43 ((2)): (270-279). [PMID:23082579] |
23. Yi Shen,Jianhua Zou,Dan Xie,Hanlin Ge,Xiuping Cao,Jungui Dai. (2012-11-06) Butyrolactone and cycloheptanetrione from mangrove-associated fungus Aspergillus terreus.. Chemical & pharmaceutical bulletin, 60 ((11)): (1437-1441). [PMID:23124567] |
24. Toyotaka Murakami,Mutsumi Matsukawa,Narumi Katsuyama,Masato Imada,Shin Aizawa,Takaaki Sato. (2012-11-07) Stress-related activities induced by predator odor may become indistinguishable by hinokitiol odor.. Neuroreport, 23 ((18)): (1071-1076). [PMID:23128452] |
25. Christine Meck,Noushad Mohd,Ryan P Murelli. (2012-11-22) An oxidopyrylium cyclization/ring-opening route to polysubstituted α-hydroxytropolones.. Organic letters, 14 ((23)): (5988-5991). [PMID:23167954] |
26. Kuan H Lin,Jinn R Kuo,Wan J Lu,Chi L Chung,Duen S Chou,Shih Y Huang,Hsiu C Lee,Joen R Sheu. (2013-03-12) Hinokitiol inhibits platelet activation ex vivo and thrombus formation in vivo.. Biochemical pharmacology, 85 ((10)): (1478-1485). [PMID:23473801] |
27. E V Pradedova,I S Trukhan,O D Nimaeva,R K Salyaev. (2013-05-09) Hydrogen peroxide generation in the vacuoles of red beet root cells.. Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 449 (106-109). [PMID:23652440] |
28. Brian D Herman,Nicolas Sluis-Cremer. (2013-08-10) Transient kinetic analyses of the ribonuclease H cleavage activity of HIV-1 reverse transcriptase in complex with efavirenz and/or a β-thujaplicinol analogue.. The Biochemical journal, 455 ((2)): (179-184). [PMID:23927736] |
29. Tomas F M Kuijpers,Harry Gruppen,Stefano Sforza,Willem J H van Berkel,Jean-Paul Vincken. (2013-10-12) The antibrowning agent sulfite inactivates Agaricus bisporus tyrosinase through covalent modification of the copper-B site.. The FEBS journal, 280 ((23)): (6184-6195). [PMID:24112416] |
30. Yasuhiko Higashi,Youichi Fujii. (2013-10-22) Determination of hinokitiol in skin lotion by high-performance liquid chromatography-ultraviolet detection after precolumn derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole.. Journal of cosmetic science, 64 ((5)): (381-389). [PMID:24139436] |
31. Dejun Li,Zhi Deng,Changren Liu,Manman Zhao,Huina Guo,Zhihui Xia,Hui Liu. (2014-07-24) Molecular cloning, expression profiles, and characterization of a novel polyphenol oxidase (PPO) gene in Hevea brasiliensis.. Bioscience, biotechnology, and biochemistry, 78 ((10)): (1648-1655). [PMID:25051980] |
32. Perng-Kuang Chang,Leslie L Scharfenstein,Brian Mack,Qijian Wei,Matthew Gilbert,Matthew Lebar,Jeffrey W Cary. (2019-05-01) Identification of a copper-transporting ATPase involved in biosynthesis of A. flavus conidial pigment.. Applied microbiology and biotechnology, 103 ((12)): (4889-4897). [PMID:31037381] |
33. Eric Sabondjian,Andrea J Mitchell,Gerald Wisenberg,James White,Kimberley J Blackwood,Jane Sykes,Lela Deans,Robert Z Stodilka,Frank S Prato. (2012-02-22) Hybrid SPECT/cardiac-gated first-pass perfusion CT: locating transplanted cells relative to infarcted myocardial targets.. Contrast media & molecular imaging, 7 ((1)): (76-84). [PMID:22344883] |
34. Che-Jen Hsiao,Shih-Hsin Hsiao,Wei-Lin Chen,Jih-Hwa Guh,George Hsiao,Yen-Ju Chan,Tzong-Huei Lee,Chi-Li Chung. (2012-03-28) Pycnidione, a fungus-derived agent, induces cell cycle arrest and apoptosis in A549 human lung cancer cells.. Chemico-biological interactions, 197 ((1)): (23-30). [PMID:22450442] |
35. Mengcen Wang,Makoto Hashimoto,Yasuyuki Hashidoko. (2013-01-15) Carot-4-en-9,10-diol, a conidiation-inducing sesquiterpene diol produced by Trichoderma virens PS1-7 upon exposure to chemical stress from highly active iron chelators.. Applied and environmental microbiology, 79 ((6)): (1906-1914). [PMID:23315728] |
36. Jessica L Fullagar,Amanda L Garner,Anjali K Struss,Joshua A Day,David P Martin,Jing Yu,Xiaoqing Cai,Kim D Janda,Seth M Cohen. (2013-03-14) Antagonism of a zinc metalloprotease using a unique metal-chelating scaffold: tropolones as inhibitors of P. aeruginosa elastase.. Chemical communications (Cambridge, England), 49 ((31)): (3197-3199). [PMID:23482955] |
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