TTI-101 , CAS No.T614575, Inhibitor of signal transducer and activator of transcription 3

Item Number
T614575
Grouped product items
SKUSizeAvailabilityPrice Qty
T614575-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
T614575-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,001.90

Basic Description

SynonymsC188-9 | 432001-19-9 | TTI-101 | STAT3 inhibitor TTI-101 | TTI101 | Stat3 inhibitor c188-9 | N-(1',2-dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide | C-188-9 | TTI 101 | KZ3DLD11RQ | N-[4-hydroxy-3-(2-hydroxynaphthalen-1-yl)naphthalen-1-yl]-4-methoxybenzene
Specifications & PurityMoligand™
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of signal transducer and activator of transcription 3

Associated Targets(Human)

STAT3 Tchem Signal transducer and activator of transcription 3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
STAT3 Tchem Signal transducer and activator of transcription 3 (3313 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AGS (1999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MKN-1 (175 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MKN-28 (466 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Kasumi 1 (420 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GDM-1 (82 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name N-[4-hydroxy-3-(2-hydroxynaphthalen-1-yl)naphthalen-1-yl]-4-methoxybenzenesulfonamide
INCHI InChI=1S/C27H21NO5S/c1-33-18-11-13-19(14-12-18)34(31,32)28-24-16-23(27(30)22-9-5-4-8-21(22)24)26-20-7-3-2-6-17(20)10-15-25(26)29/h2-16,28-30H,1H3
InChi Key QDCJDYWGYVPBDO-UHFFFAOYSA-N
Canonical SMILES COc1ccc(cc1)S(=O)(=O)Nc1cc(c(c2ccccc12)O)c1c(ccc2ccccc12)O
Isomeric SMILES COC1=CC=C(C=C1)S(=O)(=O)NC2=CC(=C(C3=CC=CC=C32)O)C4=C(C=CC5=CC=CC=C54)O
PubChem CID 1324494

Certificates

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Related Documents

References

1. Xu X, Kasembeli MM, Jiang X, Tweardy BJ, Tweardy DJ.  (2009)  Chemical probes that competitively and selectively inhibit Stat3 activation..  PLoS One,  (3): (e4783).  [PMID:19274102] [10.1021/op500134e]
2. Jung KH, Yoo W, Stevenson HL, Deshpande D, Shen H, Gagea M, Yoo SY, Wang J, Eckols TK, Bharadwaj U et al..  (2017)  Multifunctional Effects of a Small-Molecule STAT3 Inhibitor on NASH and Hepatocellular Carcinoma in Mice..  Clin Cancer Res,  23  (18): (5537-5546).  [PMID:28533225] [10.1021/op500134e]
3. Bharadwaj U, Kasembeli MM, Robinson P, Tweardy DJ.  (2020)  Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution..  Pharmacol Rev,  72  (2): (486-526).  [PMID:32198236] [10.1021/op500134e]
4. Brotherton-Pleiss C, Yue P, Zhu Y, Nakamura K, Chen W, Fu W, Kubota C, Chen J, Alonso-Valenteen F, Mikhael S et al..  (2021)  Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors..  J Med Chem,  64  (1): (695-710).  [PMID:33352047] [10.1021/op500134e]

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