TTK21 - 98%, high purity , CAS No.709676-56-2, Activator of CREB binding protein;Activator of E1A binding protein p300

Item Number
T412833
Grouped product items
SKUSizeAvailabilityPrice Qty
T412833-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$70.90
T412833-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$121.90
T412833-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$392.90
T412833-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$587.90
T412833-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$835.90

Basic Description

Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsTTK21 is a CBP/p300 histone acetyltransferase activator.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeACTIVATOR
Mechanism of actionActivator of CREB binding protein;Activator of E1A binding protein p300
Product Description

Information

TTK21 is a CBP/p300 histone acetyltransferase activator.

Associated Targets(Human)

EP300 Tchem Histone acetyltransferase p300 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CREBBP Tchem CREB-binding protein (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name N-[4-chloro-3-(trifluoromethyl)phenyl]-2-propoxybenzamide
INCHI InChI=1S/C17H15ClF3NO2/c1-2-9-24-15-6-4-3-5-12(15)16(23)22-11-7-8-14(18)13(10-11)17(19,20)21/h3-8,10H,2,9H2,1H3,(H,22,23)
InChi Key AQJBXYBDNZHZRE-UHFFFAOYSA-N
Canonical SMILES CCCOC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)Cl)C(F)(F)F
Isomeric SMILES CCCOC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)Cl)C(F)(F)F
PubChem CID 68453302
Molecular Weight 357.75

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot NumberCertificate TypeDateItem
L2319042Certificate of AnalysisDec 04, 2023 T412833
L2319047Certificate of AnalysisDec 04, 2023 T412833
L2319048Certificate of AnalysisDec 04, 2023 T412833
L2319053Certificate of AnalysisDec 04, 2023 T412833
L2319056Certificate of AnalysisDec 04, 2023 T412833
L2319057Certificate of AnalysisDec 04, 2023 T412833

Related Documents

References

1. Chatterjee S, Mizar P, Cassel R, Neidl R, Selvi BR, Mohankrishna DV, Vedamurthy BM, Schneider A, Bousiges O, Mathis C et al..  (2013)  A novel activator of CBP/p300 acetyltransferases promotes neurogenesis and extends memory duration in adult mice..  J Neurosci,  33  (26): (10698-712).  [PMID:23804093]
2. Singh AK, Neo SH, Liwang C, Pang KKL, Leng JCK, Sinha SH, Shetty MS, Vasudevan M, Rao VJ, Joshi I et al..  (2022)  Glucose derived carbon nanosphere (CSP) conjugated TTK21, an activator of the histone acetyltransferases CBP/p300, ameliorates amyloid-beta 1-42 induced deficits in plasticity and associativity in hippocampal CA1 pyramidal neurons..  Aging Cell,  21  (9): (e13675).  [PMID:35962576]
3. Müller F, De Virgiliis F, Kong G, Zhou L, Serger E, Chadwick J, Sanchez-Vassopoulos A, Singh AK, Eswaramoorthy M, Kundu TK et al..  (2022)  CBP/p300 activation promotes axon growth, sprouting, and synaptic plasticity in chronic experimental spinal cord injury with severe disability..  PLoS Biol,  20  (9): (e3001310).  [PMID:36126035]
4. Chatterjee S, Cassel R, Schneider-Anthony A, Merienne K, Cosquer B, Tzeplaeff L, Halder Sinha S, Kumar M, Chaturbedy P, Eswaramoorthy M et al..  (2018)  Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator..  EMBO Mol Med,  10  (11): (e8587).  [PMID:30275019]

Solution Calculators