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TUG-1197 , CAS No.T614579, Agonist of FFA4 receptor
Basic Description
Synonyms | compound 34;TUG1197 |
Specifications & Purity | Moligand™ |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of FFA4 receptor |
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Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
IUPAC Name | 2-(3-fluoro-5-pyridin-2-yloxyphenyl)-3H-1,2-benzothiazole 1,1-dioxide |
INCHI | InChI=1S/C18H13FN2O3S/c19-14-9-15(11-16(10-14)24-18-7-3-4-8-20-18)21-12-13-5-1-2-6-17(13)25(21,22)23/h1-11H,12H2 |
InChi Key | LDMHZAQFLWCKDT-UHFFFAOYSA-N |
Canonical SMILES | Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 |
Isomeric SMILES | C1C2=CC=CC=C2S(=O)(=O)N1C3=CC(=CC(=C3)F)OC4=CC=CC=N4 |
PubChem CID | 86280676 |
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References
1. Watterson KR, Hansen SVF, Hudson BD, Alvarez-Curto E, Raihan SZ, Azevedo CMG, Martin G, Dunlop J, Yarwood SJ, Ulven T et al.. (2017) Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4.. Mol Pharmacol, 91 (6): (630-641). [PMID:28385906] [10.1021/op500134e] |
2. Azevedo CM, Watterson KR, Wargent ET, Hansen SV, Hudson BD, Kępczyńska MA, Dunlop J, Shimpukade B, Christiansen E, Milligan G et al.. (2016) Non-Acidic Free Fatty Acid Receptor 4 Agonists with Antidiabetic Activity.. J Med Chem, 59 (19): (8868-8878). [PMID:27570890] [10.1021/op500134e] |
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