TW-37 - 98%, high purity , CAS No.877877-35-5

Item Number

T127475

• Synonyms: TW37 | TW-37 | HY-12020 | CS-0155 | BP-25408 | EC-000.2360 | CKB87735 | Q27166769 | LS-13035 | N-(4-((2-(1,1-Dimethylethyl)phenyl)sulfonyl)phenyl)-2,3,4-trihydroxy-5-((2-(1-methylethyl)phenyl)methyl)benzamide | A922660 | N-[4-(2-tert-Butylphenylsulfonyl)p
• Specifications & Purity: ≥98%
• Biochemical and Physiological Mechanisms: TW-37 is Bcl-2 inhibitor (Ki values are 0.29 μM and 1.11 μM for Bcl-2 and Bcl-XL respectively). TW-37 inhibits the angiogenic potential of endothelial cells in vitro. TW-37 induces S-phase arrest and apoptosis in pancreatic cancer cell lines; also i
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Note: Refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Product Application：

TW-37 treatment significantly inhibited pancreatic tumor growth in vivo. Western blot analysis showed that the expression level of Notch-1 was significantly lower in tumors from the TW-37–treated mice than those from vehicle-treated control mice. In addition, the expression of Jagged-1 and Notch-1 downstream target gene, Hes-1, was also down-regulated in TW-37–treated tumors.