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TWS119 - ≥95%, high purity , CAS No.601514-19-6, Inhibitor of glycogen synthase kinase 3 beta

Moligand™
≥95%

CAS#: 601514-19-6
Formula: C₁₈H₁₄N₄O₂
Molecular Weight: 318.33
PubChem CID: 9549289

Item Number

T126075

Grouped product items
SKU	Size	Availability	Price
T126075-10mg	10mg	In stock	$86.90
T126075-25mg	25mg	In stock	$195.90
T126075-50mg	50mg	In stock	$303.90

Potent cell-permeable GSK-3β inhibitor

View related series

glycogen synthase kinase 3 beta Inhibitor

Basic Description

Synonyms	TWS119\|601514-19-6\|TWS-119\|3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol\|GSK inhibitor XII\|3-((6-(3-AMINOPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)OXY)PHENOL\|3-(6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenol\|CHEMBL405759\|3-{[
Specifications & Purity	≥95%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of glycogen synthase kinase 3 beta
Product Description	TWS119 has been used as glycogen synthase kinase-3β (GSK-3β) GSK3β inhibitor

Names and Identifiers

IUPAC Name	3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol
INCHI	InChI=1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
InChi Key	VPVLEBIVXZSOMQ-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CC(=C1)N)C2=CC3=C(N2)N=CN=C3OC4=CC=CC(=C4)O
Isomeric SMILES	C1=CC(=CC(=C1)N)C2=CC3=C(N2)N=CN=C3OC4=CC=CC(=C4)O
PubChem CID	9549289
Molecular Weight	318.33

PubChem CID

ChEMBL Ligand

CAS Registry No.

Reactome Reaction

Reactome Drug

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3 results found

Lot Number	Certificate Type	Date	Item
D2126367	Certificate of Analysis	Feb 09, 2023	T126075
D2126368	Certificate of Analysis	Feb 09, 2023	T126075
D2126369	Certificate of Analysis	Feb 09, 2023	T126075

Solubility

DMSO 64 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

Sensitivity

Heat sensitive

Melt Point(°C)

249 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H319:Causes serious eye irritation H302:Harmful if swallowed
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help.

References

1. Eldar-Finkelman H, Schreyer SA, Shinohara MM, LeBoeuf RC, Krebs EG. (1999) Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice.. Diabetes, 48 (8): (1662-6). [PMID:10426388]
2. Nikoulina SE, Ciaraldi TP, Mudaliar S, Mohideen P, Carter L, Henry RR. (2000) Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.. Diabetes, 49 (2): (263-71). [PMID:10868943]
3. Ding S, Wu TY, Brinker A, Peters EC, Hur W, Gray NS, Schultz PG. (2003) Synthetic small molecules that control stem cell fate.. Proc Natl Acad Sci USA, 100 (13): (7632-7). [PMID:12794184]
4. Cai Z, Zhao Y, Zhao B. (2012) Roles of glycogen synthase kinase 3 in Alzheimer's disease.. Curr Alzheimer Res, 9 (7): (864-79). [PMID:22272620]
5. Hurtado DE, Molina-Porcel L, Carroll JC, Macdonald C, Aboagye AK, Trojanowski JQ, Lee VM. (2012) Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease.. J Neurosci, 32 (21): (7392-402). [PMID:22623685]
6. Takashima A, Noguchi K, Sato K, Hoshino T, Imahori K. (1993) Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.. Proc Natl Acad Sci USA, 90 (16): (7789-93). [PMID:8356085]

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TWS119 - ≥95%, high purity , CAS No.601514-19-6, Inhibitor of glycogen synthase kinase 3 beta

Basic Description

Associated Targets

GSK3B Tclin Glycogen synthase kinase-3 beta 1 Activities

Names and Identifiers

Database links