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Tyrphostin 47 - ≥99%, high purity , CAS No.122520-86-9
EGFR tyrosine kinase inhibitor
Basic Description Synonyms Tyrphostin 47|Tyrphostin A47|AG 213|AG-213|118409-60-2|122520-86-9|RG-50864|(E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethioamide|RG 50864|CHEMBL77030|2-Propenethioamide, 2-cyano-3-(3,4-dihydroxyphenyl)-|3,4-Dihydroxy-alpha-cyanothiocinnamamide|tyrphosti Specifications & Purity ≥99% Biochemical and Physiological Mechanisms Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (IC 50 = 2.4 μM). Also inhibits platelet-derived growth factor (PDGF) receptor tyrosine kinase. Source Synthetic Storage Temp Room temperature Shipped In Normal Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. Product Description Store at Room Temperature. The product can be stored for up to 12 months.
Names and Identifiers IUPAC Name (E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethioamide INCHI InChI=1S/C10H8N2O2S/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+ InChi Key ZGHQGWOETPXKLY-XVNBXDOJSA-N Canonical SMILES C1=CC(=C(C=C1C=C(C#N)C(=S)N)O)O Isomeric SMILES C1=CC(=C(C=C1/C=C(\C#N)/C(=S)N)O)O PubChem CID 667601 Molecular Weight 220.2
Chemical and Physical Properties Solubility Soluble in DMSO to 75 mM and in ethanol to 75 mM
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
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