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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Basic Description
| Synonyms | ((4-HYDROXYPHENYL)METHYLENE)PROPANEDINITRILE | (E)-3-Octenoic acid | 2-Hydroxybenzalmalononitrile | BDBM4324 | KBio2_000539 | Tyrphostin-8 | Q27185965 | TYRPHOSTIN AG 10 | 2-Tridecenoic acid, (2E)- | HY-W174279 | NCGC00163461-03 | Propanedinitrile, ((4-hy |
|---|---|
| Specifications & Purity | ≥98% |
| Biochemical and Physiological Mechanisms | Tyrosine kinase inhibitor. Inhibits EGFR tyrosine kinase activity (IC 50 = 560 μM). Also inhibits calcineuin phosphatase activity (IC 50 = 21 μM). Active in vivo and in vitro . |
| Storage Temp | Room temperature |
| Shipped In | Normal |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Product Description | Store at Room Temperature. The product can be stored for up to 12 months. |
Associated Targets(Human)
CISD1 Tchem CDGSH iron-sulfur domain-containing protein 1 (1 Activities)
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
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VDR Tclin Vitamin D receptor (26531 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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COMT Tclin Catechol O-methyltransferase (404 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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CISD1 Tchem CDGSH iron-sulfur domain-containing protein 1 (222 Activities)
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Associated Targets(non-human)
GCN5 Histone acetyltransferase GCN5 (89 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Rorc Nuclear receptor ROR-gamma (89407 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | 2-[(4-hydroxyphenyl)methylidene]propanedinitrile |
|---|---|
| INCHI | InChI=1S/C10H6N2O/c11-6-9(7-12)5-8-1-3-10(13)4-2-8/h1-5,13H |
| InChi Key | FNCOVSWSZZVFBQ-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC(=CC=C1C=C(C#N)C#N)O |
| Isomeric SMILES | C1=CC(=CC=C1C=C(C#N)C#N)O |
| PubChem CID | 92970 |
| Molecular Weight | 170.2 |
Certificates
Certificate of Analysis(COA)
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Chemical and Physical Properties
| Solubility | Soluble in DMSO to 100 mM and in ethanol to 100 mM |
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Safety and Hazards(GHS)
| Pictogram(s) | GHS06 |
|---|---|
| Signal | Danger |
| Hazard Statements | H301:Toxic if swallowed |
| Precautionary Statements | P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately. |