Tyrphostin AG 494 - >98.0%(HPLC)(N), high purity , CAS No.133550-35-3

Item Number

T162509

Grouped product items
SKU	Size	Availability	Price
T162509-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$80.90
T162509-25mg	25mg	In stock	$195.90
T162509-100mg	100mg	In stock	$489.90

Potent, selective EGF receptor tyrosine kinase

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Basic Description

Synonyms	133550-35-3\|Tyrphostin B48\|AG 494\|AG-494\|Tyrphostin AG 494\|Tyrphostin AG-494\|(E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylacrylamide\|139087-53-9\|alpha-Cyano-(3,4-dihydroxy)-N-phenylcinnamide\|(E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-PHENYL-2-PROPENAMIDE\|CHEMBL
Specifications & Purity	>98.0%(HPLC)(N)
Storage Temp	Store at -20°C
Shipped In	Dry ice
Product Description	AG-494 (Tyrphostin AG 494) is a potent and selective EGFR tyrosine kinase inhibitor (IC50=0.7 μM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC50s 1.1, 39, 45 and 6 μM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis

Names and Identifiers

IUPAC Name	(E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-2-enamide
INCHI	InChI=1S/C16H12N2O3/c17-10-12(8-11-6-7-14(19)15(20)9-11)16(21)18-13-4-2-1-3-5-13/h1-9,19-20H,(H,18,21)/b12-8+
InChi Key	HKHOVJYOELRGMV-XYOKQWHBSA-N
Canonical SMILES	C1=CC=C(C=C1)NC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N
Isomeric SMILES	C1=CC=C(C=C1)NC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N
PubChem CID	5328771
Molecular Weight	280.28
Reaxy-Rn	4322707

Certificates

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4 results found

Lot Number	Certificate Type	Date	Item
G2403730	Certificate of Analysis	Apr 13, 2024	T162509
G2403739	Certificate of Analysis	Apr 13, 2024	T162509
D2102261	Certificate of Analysis	Jan 02, 2024	T162509
A2305117	Certificate of Analysis	Jan 11, 2023	T162509

Solubility

Soluble in DMSO

Sensitivity

light sensitive

Melt Point(°C)

249 °C(dec.)

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Basic Description