Tyrphostin AG 494 - >98.0%(HPLC)(N), high purity , CAS No.133550-35-3

Item Number

T162509

• Synonyms: MKXZASYAUGDDCJ-UHFFFAOYSA-N | DTXSID201018515 | HMS3414I07 | s6509 | AKOS024458583 | HMS2232N04 | NCGC00024687-02 | BCP29134 | NCGC00016019-03 | AG-494 | HY-101042 | MLS002172496 | 5-(gamma-Methylaminopropyl)iminodibenzyl | CS-0020753 | NCGC00261832-01 |
• Specifications & Purity: ≥98%(HPLC)(N)
• Biochemical and Physiological Mechanisms: Potent, selective EGF receptor tyrosine kinase inhibitor (IC 50 = 0.7 μM). Selective over ErbB2, PDGF receptor tyrosine kinase and insulin receptor (IC 50 values are 42, 6 and 100 μM respectively).
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

AG-494 (Tyrphostin AG 494) is a potent and selective EGFR tyrosine kinase inhibitor (IC50=0.7 μM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC50s 1.1, 39, 45 and 6 μM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis