Tyrphostin AG 879 - ≥98%, high purity , CAS No.148741-30-4

Item Number

T129799

• Synonyms: 2-dicyclohexylphosphino-2',6' dimethoxybiphenyl | Tyrphostin AG 879 | 2-Propenethioamide, 3-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)-2-cyano-, (E)- | alpha-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide | BCP08354 | SR-01000076151-1 | BiomolKI_000028 |
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Tyrphostin AG 879 is a protein tyrosine kinase inhibitor with potent effects on TrkA. This product reportedly inhibits NGF-induced PLC-γ 1 phosphorylation and phosphatidylinositol-3 kinase activation. Has been shown in lab studies to disrupt Sertoli cell
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

TyrphostinAG879 is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation, but not TrKB and TrKC.[1] also a ErbB2 kinase inhibitor, has at least 500-fold higher selectivity to ErbB2 (IC50 = 1 μmol/L) than EGFR (IC50 >500 μmol/L).
A protein tyrosine kinase inhibitor with potent effects on TrkA