Grouped product items

SKU

Size

Availability

Price

Qty

T288351-10mg

10mg

In stock

$395.90

T288351-50mg

50mg

In stock

$1,137.90

T288351-250mg

250mg

Available within 4-8 weeks(?)

$5,121.90

Basic Description

Synonyms	Tyrphostin AG 835\|133550-37-5\|Tyrphostin B44, (+) enantiomer\|Tyrphostin B50\|(S,E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(1-phenylethyl)acrylamide\|(E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1S)-1-phenylethyl]prop-2-enamide\|(+)-Tyrphostin B44\|(2E)-2-cyano-3-(3,4-d
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Epidermal growth factor receptor (EGFR) kinase inhibitor (IC50= 0.86μM). Slightly less active than the(-) enantiomer.(-)-enantiomeralso available.
Storage Temp	Protected from light,Store at -20°C,Argon charged,Desiccated
Shipped In	Ice chest + Ice pads
Product Description	Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM. Less active than the (-) enantiomer.

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

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CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

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CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

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CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

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EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

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CBX1 Tbio Chromobox protein homolog 1 0 Activities

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CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

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GMNN Tbio Geminin 0 Activities

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POLH Tchem DNA polymerase eta 0 Activities

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RORC Tchem Nuclear receptor ROR-gamma 0 Activities

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USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 0 Activities

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VDR Tclin Vitamin D3 receptor 0 Activities

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FTL Tbio Ferritin light chain 0 Activities

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HIF1A Tchem Hypoxia-inducible factor 1-alpha 0 Activities

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HSD17B10 Tchem 3-hydroxyacyl-CoA dehydrogenase type-2 0 Activities

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KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

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HDAC6 Tclin Histone deacetylase 6 0 Activities

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THPO Tbio Thrombopoietin 0 Activities

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TXNRD1 Tclin Thioredoxin reductase 1, cytoplasmic 0 Activities

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SMN1 Tchem Survival motor neuron protein 0 Activities

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TSHR Tclin Thyrotropin receptor 0 Activities

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POLK Tbio DNA polymerase kappa 0 Activities

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POLI Tchem DNA polymerase iota 0 Activities

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RGS12 Tbio Regulator of G-protein signaling 12 0 Activities

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PMP22 Tbio Peripheral myelin protein 22 0 Activities

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RGS4 Tchem Regulator of G-protein signaling 4 0 Activities

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ALOX12 Tchem Arachidonate 12-lipoxygenase, 12S-type 0 Activities

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ALOX15B Tchem Arachidonate 15-lipoxygenase B 0 Activities

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ALOX15 Tchem Arachidonate 15-lipoxygenase 0 Activities

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MPHOSPH8 Tbio M-phase phosphoprotein 8 0 Activities

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HSPA5 Tchem Endoplasmic reticulum chaperone BiP 0 Activities

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BLM Tchem Bloom syndrome protein 0 Activities

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ATXN2 Tbio Ataxin-2 0 Activities

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COMT Tclin Catechol O-methyltransferase 0 Activities

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

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APOBEC3G Tchem DNA dC->dU-editing enzyme APOBEC-3G 0 Activities

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APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

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GLA Tclin Alpha-galactosidase A 0 Activities

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ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

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MAPT Tclin Microtubule-associated protein tau 0 Activities

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ARSA Tbio Arylsulfatase A 0 Activities

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IMPA1 Tclin Inositol monophosphatase 1 0 Activities

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TP53 Tchem Cellular tumor antigen p53 0 Activities

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KDM4E Tchem Lysine-specific demethylase 4E 0 Activities

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MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

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NFKB1 Tclin Nuclear factor NF-kappa-B p105 subunit 0 Activities

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Names and Identifiers

IUPAC Name	(E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1S)-1-phenylethyl]prop-2-enamide
INCHI	InChI=1S/C18H16N2O3/c1-12(14-5-3-2-4-6-14)20-18(23)15(11-19)9-13-7-8-16(21)17(22)10-13/h2-10,12,21-22H,1H3,(H,20,23)/b15-9+/t12-/m0/s1
InChi Key	UMGQVUWXNOJOSJ-DGGAMASNSA-N
Canonical SMILES	CC(C1=CC=CC=C1)NC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N
Isomeric SMILES	C[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N
PubChem CID	5328769
Molecular Weight	308.34

Certificates

Certificate of Analysis(COA)

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3 results found

Lot Number	Certificate Type	Date	Item
K2101128	Certificate of Analysis	Aug 19, 2024	T288351
K2101168	Certificate of Analysis	Aug 19, 2024	T288351
K2101169	Certificate of Analysis	Aug 19, 2024	T288351

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 9.25, Max Conc. mM: 30
Sensitivity	light & heat & air sensitive
Specific Rotation[α]	96° (C=0.5,MeOH)
Melt Point(°C)	146 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS08
Signal	Warning
Hazard Statements	H373:Causes damage to organs through prolonged or repeated exposure H371:May cause damage to organs
Precautionary Statements	P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P308+P316:IF exposed or concerned: Get emergency medical help immediately. P319:Get medical help if you feel unwell.

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Tyrphostin B44, (+) enantiomer - 98%, high purity , CAS No.133550-37-5