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U-18666A - 10mM in DMSO, high purity , CAS No.3039-71-2
Inhibitor of cholesterol synthesis and cellular\xa0transport
Basic Description Synonyms 3039-71-2 | U18666A | U 18666A | U-18666A | 3beta-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride | U 18,666A | U-18,666A | NSC 70801 | NSC-70801 | V0DPR5J8ZJ | DTXSID3046904 | (3S,8R,9S,10R,13S,14S)-3-[2-(diethylamino)ethoxy]-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,1 Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms Inhibitor of cholesterol synthesis and cellular transport. Impairs intracellular transport of LDL-derived cholesterol in CHO cells. Blocks the ability of LDL-derived cholesterol to suppress HMG-CoA reductase and LDL receptor activity. Weak inhibitor of He Storage Temp Store at -80°C Shipped In Ice chest + Ice pads
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (3S,8R,9S,10R,13S,14S)-3-[2-(diethylamino)ethoxy]-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one;hydrochloride INCHI InChI=1S/C25H41NO2.ClH/c1-5-26(6-2)15-16-28-19-11-13-24(3)18(17-19)7-8-20-21-9-10-23(27)25(21,4)14-12-22(20)24;/h7,19-22H,5-6,8-17H2,1-4H3;1H/t19-,20-,21-,22-,24-,25-;/m0./s1 InChi Key GZFYZYBWLCYBMI-MYZJJQSMSA-N Canonical SMILES CCN(CC)CCOC1CCC2(C3CCC4(C(C3CC=C2C1)CCC4=O)C)C.Cl Isomeric SMILES CCN(CC)CCO[C@H]1CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3CC=C2C1)CCC4=O)C)C.Cl WGK Germany 3 PubChem CID 9954082 Molecular Weight 424.06
Safety and Hazards(GHS) WGK Germany 3 RIDADR NONHforallmodesoftransport
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