Grouped product items

SKU

Size

Availability

Price

Qty

U333272-25mg

25mg

Available within 8-12 weeks(?)

$95.90

Basic Description

Synonyms	SPIRADOLINE\|Spiradoline [INN]\|2-(3,4-dichlorophenyl)-N-methyl-N-[(5R,7S,8S)-7-pyrrolidin-1-yl-1-oxaspiro[4.5]decan-8-yl]acetamide\|N18ZH0M4NP\|CHEMBL70586\|DTXSID1048679\|DTXCID1028605\|MLS002153429\|CAS-87151-85-7\|Spiradolinum [Latin]\|Espiradolina [Spanish]\|SM
Specifications & Purity	Moligand™
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of κ receptor
Product Description	U-62066 is a highly selective κ opioid receptor agonist as well as an antitussive.

Associated Targets

CTH Tchem Cystathionine gamma-lyase 0 Activities

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CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

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CNR1 Tclin Cannabinoid receptor 1 0 Activities

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DRD2 Tclin D(2) dopamine receptor 0 Activities

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DRD4 Tchem D(4) dopamine receptor 0 Activities

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CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

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ERBB2 Tclin Receptor tyrosine-protein kinase erbB-2 0 Activities

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ELANE Tclin Neutrophil elastase 0 Activities

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EGFR Tclin Epidermal growth factor receptor 0 Activities

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AVPR1A Tclin Vasopressin V1a receptor 0 Activities

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HMGCR Tclin 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0 Activities

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HDAC6 Tclin Histone deacetylase 6 0 Activities

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HRH1 Tclin Histamine H1 receptor 0 Activities

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SLC6A3 Tclin Sodium-dependent dopamine transporter 0 Activities

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SLC6A4 Tclin Sodium-dependent serotonin transporter 0 Activities

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SIGMAR1 Tclin Sigma non-opioid intracellular receptor 1 0 Activities

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PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities

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CA2 Tclin Carbonic anhydrase 2 0 Activities

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DRD3 Tclin D(3) dopamine receptor 0 Activities

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FLT1 Tclin Vascular endothelial growth factor receptor 1 0 Activities

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CHRM3 Tclin Muscarinic acetylcholine receptor M3 0 Activities

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CHRM4 Tclin Muscarinic acetylcholine receptor M4 0 Activities

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ADRA2B Tclin Alpha-2B adrenergic receptor 0 Activities

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ADRA2C Tclin Alpha-2C adrenergic receptor 0 Activities

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APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

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HTR2A Tclin 5-hydroxytryptamine receptor 2A 0 Activities

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ADORA2A Tclin Adenosine receptor A2a 0 Activities

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ACHE Tclin Acetylcholinesterase 0 Activities

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ADRA1B Tclin Alpha-1B adrenergic receptor 0 Activities

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ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

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ADRA1A Tclin Alpha-1A adrenergic receptor 0 Activities

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AR Tclin Androgen receptor 0 Activities

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MAOA Tclin Amine oxidase [flavin-containing] A 0 Activities

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AKR1B1 Tclin Aldose reductase 0 Activities

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ADORA1 Tclin Adenosine receptor A1 0 Activities

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HTR1A Tclin 5-hydroxytryptamine receptor 1A 0 Activities

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ADORA3 Tchem Adenosine receptor A3 0 Activities

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HTR6 Tchem 5-hydroxytryptamine receptor 6 0 Activities

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HTR2B Tclin 5-hydroxytryptamine receptor 2B 0 Activities

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EDNRA Tclin Endothelin-1 receptor 0 Activities

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KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

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OPRD1 Tclin Delta-type opioid receptor 0 Activities

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OPRK1 Tclin Kappa-type opioid receptor 5 Activities

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OPRM1 Tclin Mu-type opioid receptor 1 Activities

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NOS2 Tchem Nitric oxide synthase, inducible 0 Activities

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TACR1 Tclin Substance-P receptor 0 Activities

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NOS1 Tchem Nitric oxide synthase, brain 0 Activities

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Names and Identifiers

IUPAC Name	2-(3,4-dichlorophenyl)-N-methyl-N-[(5R,7S,8S)-7-pyrrolidin-1-yl-1-oxaspiro[4.5]decan-8-yl]acetamide
INCHI	InChI=1S/C22H30Cl2N2O2/c1-25(21(27)14-16-5-6-17(23)18(24)13-16)19-7-9-22(8-4-12-28-22)15-20(19)26-10-2-3-11-26/h5-6,13,19-20H,2-4,7-12,14-15H2,1H3/t19-,20-,22-/m0/s1
InChi Key	NYKCGQQJNVPOLU-ONTIZHBOSA-N
Canonical SMILES	CN(C1CCC2(CCCO2)CC1N3CCCC3)C(=O)CC4=CC(=C(C=C4)Cl)Cl
Isomeric SMILES	CN([C@H]1CC[C@@]2(CCCO2)C[C@@H]1N3CCCC3)C(=O)CC4=CC(=C(C=C4)Cl)Cl
WGK Germany	3
PubChem CID	55652
Molecular Weight	521.5

Database links

PubChem CID	55652
Wikipedia	Spiradoline
BindingDB Ligand	50000783
CAS Registry No.	87151-85-7
ChEMBL Ligand	CHEMBL70586
GPCRdb Ligand	spiradoline

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility	Soluble in water: 14 mg/mL
Melt Point(°C)	214-218° C

Safety and Hazards(GHS)

WGK Germany	3
RIDADR	NONHforallmodesoftransport

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U-62066 , CAS No.87151-85-7, Agonist of κ receptor