Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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U274745-1mg | 1mg | In stock | $14.90 | |
U274745-5mg | 5mg | In stock | $56.90 | |
U274745-10mg | 10mg | In stock | $86.90 | |
U274745-25mg | 25mg | In stock | $166.90 |
Selective MKK inhibitor
Specifications & Purity | Moligand™, ≥98% |
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Biochemical and Physiological Mechanisms | Selective non-competitive inhibitor of MAP kinase kinase (MKK). Inhibits MKK1, MKK2 (IC 50 values of 0.07 and 0.06 μM, respectively) and MKK5 with little or no effect on a wide range of other kinases. Centrally active following systemic administration in |
Storage Temp | Store at -20°C,Argon charged,Desiccated |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile |
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INCHI | InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+ |
InChi Key | DVEXZJFMOKTQEZ-JYFOCSDGSA-N |
Canonical SMILES | C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N |
Isomeric SMILES | C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\N)/C#N)\C#N)/N |
PubChem CID | 3006531 |
Molecular Weight | 380.49 |
CAS Registry No. | 109511-58-2 |
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Wikipedia | U0126 |
PubChem CID | 3006531 |
ChEMBL Ligand | CHEMBL34704 |
RCSB PDB Ligand | 5BM |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
J2429531 | Certificate of Analysis | Nov 05, 2024 | U274745 |
J2429532 | Certificate of Analysis | Nov 02, 2024 | U274745 |
J2429533 | Certificate of Analysis | Nov 02, 2024 | U274745 |
J2429534 | Certificate of Analysis | Nov 02, 2024 | U274745 |
H2430063 | Certificate of Analysis | Sep 10, 2024 | U274745 |
I2220672 | Certificate of Analysis | Sep 26, 2022 | U274745 |
I2220679 | Certificate of Analysis | Sep 26, 2022 | U274745 |
I2220680 | Certificate of Analysis | Sep 26, 2022 | U274745 |
I2220681 | Certificate of Analysis | Sep 26, 2022 | U274745 |
Solubility | Soluble in DMSO to 100 mM |
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1. Zhou Jin, Ding Yuanyuan, Zhang Yongqiang, Zheng Dehui, Yan Lifeng, Guo Mengxiang, Mao Yani, Yang Lihong. (2023) Exosomes from bone marrow-derived mesenchymal stem cells facilitate corneal wound healing via regulating the p44/42 MAPK pathway. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 261 (3): (723-734). [PMID:36576571] [10.1007/s00417-022-05956-4] |
2. Shixuan Cui, Yang Yu, Tingjie Zhan, Yuchen Gao, Jiachen Zhang, Liang Zhang, Zhiwei Ge, Weiping Liu, Chunlong Zhang, Shulin Zhuang. (2022) Carcinogenic Risk of 2,6-Di-tert-Butylphenol and Its Quinone Metabolite 2,6-DTBQ Through Their Interruption of RARβ: In Vivo, In Vitro, and In Silico Investigations. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 56 (1): (480–490). [PMID:34927421] [10.1021/acs.est.1c06866] |
3. Shuli Fan,Xiang Gao,Peng Chen,Xu Li. (2018-06-09) Myricetin ameliorates glucocorticoid-induced osteoporosis through the ERK signaling pathway.. Life sciences, 207 (205-211). [PMID:29883721] |
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20. Zhou Jin, Ding Yuanyuan, Zhang Yongqiang, Zheng Dehui, Yan Lifeng, Guo Mengxiang, Mao Yani, Yang Lihong. (2023) Exosomes from bone marrow-derived mesenchymal stem cells facilitate corneal wound healing via regulating the p44/42 MAPK pathway. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 261 (3): (723-734). [PMID:36576571] [10.1007/s00417-022-05956-4] |
21. Shixuan Cui, Yang Yu, Tingjie Zhan, Yuchen Gao, Jiachen Zhang, Liang Zhang, Zhiwei Ge, Weiping Liu, Chunlong Zhang, Shulin Zhuang. (2022) Carcinogenic Risk of 2,6-Di-tert-Butylphenol and Its Quinone Metabolite 2,6-DTBQ Through Their Interruption of RARβ: In Vivo, In Vitro, and In Silico Investigations. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 56 (1): (480–490). [PMID:34927421] [10.1021/acs.est.1c06866] |
22. Shuli Fan,Xiang Gao,Peng Chen,Xu Li. (2018-06-09) Myricetin ameliorates glucocorticoid-induced osteoporosis through the ERK signaling pathway.. Life sciences, 207 (205-211). [PMID:29883721] |