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U73122 - 97%, high purity , CAS No.112648-68-7

  • Moligand™
  • ≥97%
Item Number
U302223
Grouped product items
SKUSizeAvailabilityPrice Qty
U302223-5mg
5mg
In stock
$98.90
U302223-10mg
10mg
In stock
$152.90
U302223-25mg
25mg
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$342.90
U302223-50mg
50mg
In stock
$630.90
U302223-100mg
100mg
In stock
$1,135.90
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Bulk Order  SDS  DATASHEET

Discover U73122 by Aladdin Scientific in 97% for only $98.90. Available - in Ligands at Aladdin Scientific. Standard phospholipase C (PLC) inhibitor Tags: TRPC2 Channel blocker.

View related series
TRPC2 Channel blocker

Basic Description

Synonyms112648-68-7|U-73122|U73122|U 73122|1-(6-((3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione|U-73,122|U-73122 hydrate|CHEMBL1256678|CHEBI:90690|1-[6-[[(8R,9S,13S,14S,17S)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopent
Specifications & Purity97%
Storage TempStore at -20°C
Shipped InDry ice
GradeMoligand™
Product Description

Application：

It is used as a phospholipase C, phospholipase A2, and 5-LO inhibitor. It is also determined that in SK-N-SH neuroblastoma cells, U-73122 inhibits agonist-induced down-regulation of muscarinic receptors. In addition, it is a useful tool to investigate receptor-mediated PI turnover in signal transduction. U-73122 is a potent inhibitor of human neutrophil adhesion to biological surfaces (IC50 = 50 nM) as well as adhesion-dependent granule exocytosis and oxidative burst. U-73343 (sc-201422) is useful as a negative control for investigations of U-73122 phospholipase C antagonism and its cellular consequences.


Associated Targets

TERT Tchem Telomerase reverse transcriptase 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488187372
IUPAC Name 1-[6-[[(8R,9S,13S,14S,17S)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]amino]hexyl]pyrrole-2,5-dione
INCHI InChI=1S/C29H40N2O3/c1-29-16-15-23-22-10-8-21(34-2)19-20(22)7-9-24(23)25(29)11-12-26(29)30-17-5-3-4-6-18-31-27(32)13-14-28(31)33/h8,10,13-14,19,23-26,30H,3-7,9,11-12,15-18H2,1-2H3/t23-,24-,25+,26+,29+/m1/s1
InChi Key LUFAORPFSVMJIW-ZRJUGLEFSA-N
Canonical SMILES CC12CCC3C(C1CCC2NCCCCCCN4C(=O)C=CC4=O)CCC5=C3C=CC(=C5)OC
Isomeric SMILES C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2NCCCCCCN4C(=O)C=CC4=O)CCC5=C3C=CC(=C5)OC
PubChem CID 104794
Molecular Weight 464.64

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

11 results found

Lot NumberCertificate TypeDateItem
B2419130Certificate of AnalysisMar 30, 2023 U302223
E23151213Certificate of AnalysisMar 30, 2023 U302223
E23151214Certificate of AnalysisMar 30, 2023 U302223
E23151215Certificate of AnalysisMar 30, 2023 U302223
E23151216Certificate of AnalysisMar 30, 2023 U302223
E23151217Certificate of AnalysisMar 30, 2023 U302223
E23151218Certificate of AnalysisMar 30, 2023 U302223
E23151219Certificate of AnalysisMar 30, 2023 U302223
E23151220Certificate of AnalysisMar 30, 2023 U302223
E23151221Certificate of AnalysisMar 30, 2023 U302223
E23151222Certificate of AnalysisMar 30, 2023 U302223

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Chemical and Physical Properties

SolubilitySoluble in DMSO, ethanol, or DMF at approx. 0.5mg/ml. May require heating or overnight mixing. Insoluble in water

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

Related Documents

 SDS

 Specification Sheet

References

1. Kulebyakin K et al..  (2022)  Dynamic Balance between PTH1R-Dependent Signal Cascades Determines Its Pro- or Anti-Osteogenic Effects on MSC..  Cells,  11  (21):   [PMID:36359914]
2. Kárpáti A et al..  (2018)  Histamine elicits glutamate release from cultured astrocytes..  J Pharmacol Sci,      [PMID:29858014]
3. Li H et al..  (2020)  Internalization of trophoblastic small extracellular vesicles and detection of their miRNA cargo in P-bodies..  J Extracell Vesicles,  9  (1812261).  [PMID:32944196]
4. Luo R et al..  (2019)  Impaired calcium homeostasis via advanced glycation end products promotes apoptosis through endoplasmic reticulum stress in human nucleus pulposus cells and exacerbates intervertebral disc degeneration in rats..  FEBS J,  286  (21): (4356-4373).  [PMID:31230413]
5. Abdoul-Azize S et al..  (2017)  Improvement of dexamethasone sensitivity by chelation of intracellular Ca2+ in pediatric acute lymphoblastic leukemia cells through the prosurvival kinase ERK1/2 deactivation..  Oncotarget,  8  (16): (27339-27352).  [PMID:28423696]
6. Mizuno K et al..  (2020)  Role of Ca2+ transients at the node of the mouse embryo in breaking of left-right symmetry..  Sci Adv,  6  (30): (eaba1195).  [PMID:32743070]
7. Tsai CN et al..  (2019)  Serine 229 Balances the Hepatitis C Virus Nonstructural Protein NS5A between Hypo- and Hyperphosphorylated States..  J Virol,  93  (23):   [PMID:31511391]

Solution Calculators

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