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UBP 302 - ≥98%(HPLC), high purity , CAS No.745055-91-8, Antagonist of GluK1
Potent and selective kainate antagonist; active enantiomer ofUBP 296
Basic Description
| Synonyms | 2-({3-[(2S)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid | HMS3413E11 | UBP302 | UBP-302 | UBP302, >=98% (HPLC) | NCGC00025352-01 | SR-01000597533 | STK246312 | NCGC00329542-01 | DTXSID80423571 | UBP 302 | 2-Hydroxyp |
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| Specifications & Purity | Moligand™, ≥98%(HPLC) |
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| Biochemical and Physiological Mechanisms | Potent and selective GluK1 (formally GluR5)-subunit containing kainate receptor antagonist (apparent KD= 402 nM); active enantiomer of UBP 296. Displays ~ 260-fold selectivity over AMPA receptors, ~ 90-fold selectivity over recombinant human GluK2 (formal |
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| Storage Temp | Room temperature |
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| Shipped In | Normal |
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| Grade | Moligand™ |
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| Action Type | ANTAGONIST |
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| Mechanism of action | Antagonist of GluK1 |
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Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | 2-[[3-[(2S)-2-amino-2-carboxyethyl]-2,6-dioxopyrimidin-1-yl]methyl]benzoic acid |
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| INCHI | InChI=1S/C15H15N3O6/c16-11(14(22)23)8-17-6-5-12(19)18(15(17)24)7-9-3-1-2-4-10(9)13(20)21/h1-6,11H,7-8,16H2,(H,20,21)(H,22,23)/t11-/m0/s1 |
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| InChi Key | UUIYULWYHDSXHL-NSHDSACASA-N |
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| Canonical SMILES | C1=CC=C(C(=C1)CN2C(=O)C=CN(C2=O)CC(C(=O)O)N)C(=O)O |
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| Isomeric SMILES | C1=CC=C(C(=C1)CN2C(=O)C=CN(C2=O)C[C@@H](C(=O)O)N)C(=O)O |
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| WGK Germany | 3 |
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| PubChem CID | 6420161 |
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| Molecular Weight | 333.3 |
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Chemical and Physical Properties
| Solubility | Solvent:1eq. NaOH, Max Conc. mg/mL: 8.33, Max Conc. mM: 25; Solvent:DMSO, Max Conc. mg/mL: 6.67, Max Conc. mM: 20 with gentle warming |
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Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
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| Signal | Warning |
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| Hazard Statements | H302:Harmful if swallowed |
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| Precautionary Statements | P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
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| WGK Germany | 3 |
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| RIDADR | NONHforallmodesoftransport |
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