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UCB-9260 - 10mM in DMSO, high purity , CAS No.1515888-53-5
Basic Description Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms UCB-9260 is an orally active inhibitor that inhibits TNF signalling by stabilising an asymmetric form of the trimer. UCB-9260 binds TNF with Kd of 13 \u2009nM. UCB-9260 also inhibits NF-κB with IC50 of 202\u2009nM after TNF stimulation. Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description Information
UCB-9260 UCB-9260 is an orally active inhibitor that inhibits TNF signalling by stabilising an asymmetric form of the trimer. UCB-9260 binds TNF with Kd of 13 nM. UCB-9260 also inhibits NF-κB with IC50 of 202 nM after TNF stimulation.
Targets
TNF (Cell-free assay); NF-κB (Cell-free assay) 13 nM(Kd); 202 nM
Product Properties ALogP 4.432 HBD Count 1 Rotatable Bond 5
Associated Targets(Human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name [1-[(2,5-dimethylphenyl)methyl]-6-(1-methylpyrazol-4-yl)benzimidazol-2-yl]-pyridin-4-ylmethanol INCHI InChI=1S/C26H25N5O/c1-17-4-5-18(2)21(12-17)16-31-24-13-20(22-14-28-30(3)15-22)6-7-23(24)29-26(31)25(32)19-8-10-27-11-9-19/h4-15,25,32H,16H2,1-3H3 InChi Key RZGFWGNCSYUEPR-UHFFFAOYSA-N Canonical SMILES CC1=CC(=C(C=C1)C)CN2C3=C(C=CC(=C3)C4=CN(N=C4)C)N=C2C(C5=CC=NC=C5)O Isomeric SMILES CC1=CC(=C(C=C1)C)CN2C3=C(C=CC(=C3)C4=CN(N=C4)C)N=C2C(C5=CC=NC=C5)O PubChem CID 72700327 Molecular Weight 423.51
Chemical and Physical Properties DMSO(mg / mL) Max Solubility 85 DMSO(mM) Max Solubility 200.703643361432 Water(mg / mL) Max Solubility ＜1
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H302: Harmful if swallowed
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P501: Dispose of contents/container to ...
P312: Call a POISON CENTER or doctor/... if you feel unwell.
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P362: Take off contaminated clothing.
P270: Do not eat, drink or smoke when using this product.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P330: Rinse mouth.
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