Basic Description

Synonyms	56396-35-1 \| UK-5099 \| UK 5099 \| 2-Cyano-3-(1-phenylindol-3-yl)acrylate \| 2-Cpiya \| (E)-2-cyano-3-(1-phenylindol-3-yl)prop-2-enoic acid \| (E)-2-cyano-3-(1-phenyl-1H-indol-3-yl)acrylic acid \| UK5099 \| 2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid \| 2-Cyano-3-(1-phenyl
Specifications & Purity	Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms	Inhibitor of plasma membrane monocarboxylate transporters (MCTs) and the mitochondrial pyruvate carrier (MPC).UK-5099 induces lactate generation.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Product Description	application： UK-5099 has been used: as a mitochondrial pyruvate blocker to reduce pyruvate transportation into mitochondria in Roswell park memorial institute (RPMI) 1640 medium for prostatic cancer cell line culture in dimethyl sulfoxide (DMSO) stock, to study the effect of inhibiting pyruvate transport into mitochondria on pro-inflammatory responses in lipopolysaccharide activated macrophages in topical treatment in order to study its effect on hair cycle induction in experimental mice。参考sigma

Associated Targets(Human)

MPC2 Tbio Mitochondrial pyruvate carrier 2 (0 Activities)

Discover Target: MPC2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MPC1 Tbio Mitochondrial pyruvate carrier 1 (0 Activities)

Discover Target: MPC1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC16A1 Tchem Monocarboxylate transporter 1 (146 Activities)

Discover Target: SLC16A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(E)-2-cyano-3-(1-phenylindol-3-yl)prop-2-enoic acid
INCHI	InChI=1S/C18H12N2O2/c19-11-13(18(21)22)10-14-12-20(15-6-2-1-3-7-15)17-9-5-4-8-16(14)17/h1-10,12H,(H,21,22)/b13-10+
InChi Key	BIZNHCWFGNKBBZ-JLHYYAGUSA-N
Canonical SMILES	C1=CC=C(C=C1)N2C=C(C3=CC=CC=C32)C=C(C#N)C(=O)O
Isomeric SMILES	C1=CC=C(C=C1)N2C=C(C3=CC=CC=C32)/C=C(\C#N)/C(=O)O
WGK Germany	3
PubChem CID	6438504
Molecular Weight	288.3

Certificates

Certificate of Analysis(COA)

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Safety and Hazards(GHS)

WGK Germany	3

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Xiaoli Zhang, Yongxing Guo, Yi Li, Wei Liu, Hongkun Li, Yonggang Yang. (2023) Colorfully Patterned Epoxy Resin Films with a Cholesteric Structure Prepared through a Photopolymerization Approach. ACS Applied Polymer Materials, 5 (1): (193–200). [PMID:] [10.1021/acsapm.2c01432]

References

1. Xiaoli Zhang, Yongxing Guo, Yi Li, Wei Liu, Hongkun Li, Yonggang Yang. (2023) Colorfully Patterned Epoxy Resin Films with a Cholesteric Structure Prepared through a Photopolymerization Approach. ACS Applied Polymer Materials, 5 (1): (193–200). [PMID:] [10.1021/acsapm.2c01432]

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UK-5099 - 10mM in DMSO, high purity , CAS No.56396-35-1