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UNC0379 - 97%, high purity , CAS No.1620401-82-2

  • ≥97%
Item Number
U413785
Grouped product items
SKUSizeAvailabilityPrice Qty
U413785-5mg
5mg
In stock
$80.90
U413785-10mg
10mg
In stock
$147.90
U413785-25mg
25mg
In stock
$333.90
U413785-50mg
50mg
In stock
$444.90
U413785-100mg
100mg
In stock
$642.90
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SETD Inhibitors

Basic Description

Specifications & Purity≥97%
Biochemical and Physiological MechanismsUNC0379 is a selective, substrate competitive inhibitor of N-lysine methyltransferase SETD8 with IC50 of 7.9 μM, high selectivity over 15 other methyltransferases.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

Information

UNC0379 UNC0379 is a selective, substrate competitive inhibitor of N-lysine methyltransferase SETD8 with IC50 of 7.9 μM, high selectivity over 15 other methyltransferases.


Targets

SETD8 (Cell-free assay) 7.3 μM


In vitro

UNC0379 is competitive with the peptide substrate and noncompetitive with the cofactor SAM.

Product Properties

ALogP4.545
HBD Count1
Rotatable Bond10

Associated Targets(Human)

DNMT1 Tclin DNA (cytosine-5)-methyltransferase 1 (978 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SETD7 Tchem Histone-lysine N-methyltransferase SETD7 (390 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PRMT1 Tchem Protein-arginine N-methyltransferase 1 (867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PRMT3 Tchem Protein arginine N-methyltransferase 3 (219 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT1 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KMT2A Tchem Histone-lysine N-methyltransferase MLL (17327 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PRMT5 Tchem Protein arginine N-methyltransferase 5 (1273 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DOT1L Tchem Histone-lysine N-methyltransferase, H3 lysine-79 specific (648 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KMT5A Tchem N-lysine methyltransferase SETD8 (202 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SUV39H2 Tchem Histone-lysine N-methyltransferase SUV39H2 (524 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMYD2 Tchem N-lysine methyltransferase SMYD2 (395 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KMT5C Tchem Histone-lysine N-methyltransferase SUV420H2 (49 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KMT5B Tchem Histone-lysine N-methyltransferase SUV420H1 (49 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488202381
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488202381
IUPAC Name 6,7-dimethoxy-2-pyrrolidin-1-yl-N-(5-pyrrolidin-1-ylpentyl)quinazolin-4-amine
INCHI InChI=1S/C23H35N5O2/c1-29-20-16-18-19(17-21(20)30-2)25-23(28-14-8-9-15-28)26-22(18)24-10-4-3-5-11-27-12-6-7-13-27/h16-17H,3-15H2,1-2H3,(H,24,25,26)
InChi Key WEXCGGWTIDNVNT-UHFFFAOYSA-N
Canonical SMILES COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCCC3)NCCCCCN4CCCC4)OC
Isomeric SMILES COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCCC3)NCCCCCN4CCCC4)OC
PubChem CID 78357767
Molecular Weight 413.56

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot NumberCertificate TypeDateItem
D2307051Certificate of AnalysisFeb 14, 2023 U413785
D2307052Certificate of AnalysisFeb 14, 2023 U413785
D2307056Certificate of AnalysisFeb 14, 2023 U413785
D2307061Certificate of AnalysisFeb 14, 2023 U413785
D2307062Certificate of AnalysisFeb 14, 2023 U413785
D2307071Certificate of AnalysisFeb 14, 2023 U413785
D2307073Certificate of AnalysisFeb 14, 2023 U413785
D2307074Certificate of AnalysisFeb 14, 2023 U413785
D2307077Certificate of AnalysisFeb 14, 2023 U413785
D2307083Certificate of AnalysisFeb 14, 2023 U413785

Chemical and Physical Properties

SolubilitySolubility (25°C) In vitro DMSO: 82 mg/mL (198.27 mM); Water: Insoluble; Ethanol: Insoluble;
DMSO(mg / mL) Max Solubility82
DMSO(mM) Max Solubility198.2783635
Water(mg / mL) Max Solubility＜1

Related Documents

 SDS

 Specification Sheet

Solution Calculators

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