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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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U125324-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $94.90 | |
U125324-10mg | 10mg | In stock | $165.90 | |
U125324-25mg | 25mg | In stock | $373.90 | |
U125324-50mg | 50mg | In stock | $609.90 | |
U125324-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,098.90 | |
U125324-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $2,470.90 |
Synonyms | BP-21087 | GTPL8232 | SB19337 | AS-16797 | UNC1215, >=98% (HPLC) | 2-Phenylamino-1,4-bis(4-(pyrrolidinyl)piperidinyl)benzamide | UNC1215 | UNC-1215 | Butanoic acid, 2-amino-4-(methylsulfonyl)-, (.+/-.)- | EX-A193 | CCG-269911 | MFCD22683289 | HMS3426E15 | |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | UNC1215 binds L3MBTL3 with a K(d) of 120 nM, competitively displacing mono- or dimethyllysine-containing peptides, and is greater than 50-fold more potent toward L3MBTL3 than other members of the MBT family while also demonstrating selectivity against mor |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of L3MBTL histone methyl-lysine binding protein 3 |
Product Description | UNC1215 is a potent and selective MBT (malignant brain tumor) antagonist, which binds L3MBTL3 with IC50 of 40 nM and Kd of 120 nM, 50-fold selective versus other members of the human MBT family. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | [3-anilino-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone |
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INCHI | InChI=1S/C32H43N5O2/c38-31(36-20-12-27(13-21-36)34-16-4-5-17-34)25-10-11-29(30(24-25)33-26-8-2-1-3-9-26)32(39)37-22-14-28(15-23-37)35-18-6-7-19-35/h1-3,8-11,24,27-28,33H,4-7,12-23H2 |
InChi Key | PQOOIERVZAXHBP-UHFFFAOYSA-N |
Canonical SMILES | C1CCN(C1)C2CCN(CC2)C(=O)C3=CC(=C(C=C3)C(=O)N4CCC(CC4)N5CCCC5)NC6=CC=CC=C6 |
Isomeric SMILES | C1CCN(C1)C2CCN(CC2)C(=O)C3=CC(=C(C=C3)C(=O)N4CCC(CC4)N5CCCC5)NC6=CC=CC=C6 |
WGK Germany | 3 |
PubChem CID | 57339144 |
Molecular Weight | 529.72 |
ChEMBL Ligand | CHEMBL2426364 |
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PubChem CID | 57339144 |
CAS Registry No. | 1415800-43-9 |
RCSB PDB Ligand | UWN |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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A2217006 | Certificate of Analysis | Nov 10, 2023 | U125324 |
A2217016 | Certificate of Analysis | Nov 10, 2023 | U125324 |
A2217021 | Certificate of Analysis | Nov 10, 2023 | U125324 |
A2215463 | Certificate of Analysis | Oct 16, 2023 | U125324 |
A2215474 | Certificate of Analysis | Oct 16, 2023 | U125324 |
Solubility | 25°C: DMSO |
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WGK Germany | 3 |
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1. James LI, Barsyte-Lovejoy D, Zhong N, Krichevsky L, Korboukh VK, Herold JM, MacNevin CJ, Norris JL, Sagum CA, Tempel W et al.. (2013) Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain.. Nat Chem Biol, 9 (3): (184-91). [PMID:23292653] [10.1021/op500134e] |