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UNC1999 - ≥98%, high purity , CAS No.1431612-23-5, Inhibitor of enhancer of zeste 2 polycomb repressive complex 2 subunit

Moligand™
≥98%

CAS#: 1431612-23-5
Formula: C₃₃H₄₃N₇O₂
Molecular Weight: 569.74
PubChem CID: 72551585

Item Number

U125711

Grouped product items
SKU	Size	Availability	Price
U125711-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$88.90
U125711-25mg	25mg	In stock	$400.90
U125711-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$835.90

Potent, selective cell-permeable EZH2 methyltransferase inhibitor

View related series

enhancer of zeste 2 polycomb repressive complex 2 subunit Inhibitor

Basic Description

Synonyms	UNC1999\|1431612-23-5\|UNC-1999\|UNC 1999\|N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-1-propan-2-yl-6-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]indazole-4-carboxamide\|1-Isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-p
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of enhancer of zeste 2 polycomb repressive complex 2 subunit
Product Description	UNC1999 is a potent, orally bioavailable and selective inhibitor of EZH2 and EZH1 with IC50 of 2 nM and 45 nM in cell-free assays, respectively, showing >1000-fold selectivity over a broad range of epigenetic and non-epigenetic targets.

Associated Targets

EZH1 Tchem Histone-lysine N-methyltransferase EZH1 1 Activities

Discover Target: EZH1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EZH2 Tclin Histone-lysine N-methyltransferase EZH2 4 Activities

Discover Target: EZH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-1-propan-2-yl-6-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]indazole-4-carboxamide
INCHI	InChI=1S/C33H43N7O2/c1-7-8-24-15-23(6)37-33(42)28(24)19-35-32(41)27-16-26(17-30-29(27)20-36-40(30)22(4)5)25-9-10-31(34-18-25)39-13-11-38(12-14-39)21(2)3/h9-10,15-18,20-22H,7-8,11-14,19H2,1-6H3,(H,35,41)(H,37,42)
InChi Key	DPJNKUOXBZSZAI-UHFFFAOYSA-N
Canonical SMILES	CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CN=C(C=C4)N5CCN(CC5)C(C)C)C(C)C
Isomeric SMILES	CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CN=C(C=C4)N5CCN(CC5)C(C)C)C(C)C
WGK Germany	3
PubChem CID	72551585
Molecular Weight	569.74

CAS Registry No.

1431612-23-5

PubChem CID

72551585

Certificates

Certificate of Analysis(COA)

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2 results found

Lot Number	Certificate Type	Date	Item
H1618058	Certificate of Analysis	Feb 26, 2024	U125711
L2014248	Certificate of Analysis	Oct 14, 2022	U125711

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
WGK Germany	3

References

1. Konze KD, Ma A, Li F, Barsyte-Lovejoy D, Parton T, Macnevin CJ, Liu F, Gao C, Huang XP, Kuznetsova E et al.. (2013) An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1.. ACS Chem Biol, 8 (6): (1324-34). [PMID:23614352]
2. Marsolier J et al.. (2022) H3K27me3 conditions chemotolerance in triple-negative breast cancer.. Nat Genet, 54 (4): (459-468). [PMID:35410383]
3. Zijlmans DW et al.. (2022) Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction.. Nat Cell Biol, 24 (6): (858-871). [PMID:35697783]

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