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UPF 1069 - ≥98%, high purity , CAS No.1048371-03-4
Selective PARP2 inhibitor
Basic Description Synonyms HMS3653L04 | HY-14478 | SW219733-1 | 5-(2-Oxo-2-phenylethoxy)isoquinolin-1(2H)-one | CS-1466 | HMS3678B17 | MFCD14051631 | 5-(2-oxo-2-phenylethoxy)-1,2-dihydroisoquinolin-1-one | 5-Phenacyloxy-2H-isoquinolin-1-one | AC-32740 | AKOS024457781 | 1(2h)-isoqui Specifications & Purity ≥98% Biochemical and Physiological Mechanisms In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 micromolxL(-1)) caused a concentration-dependent exacerbation (up to 155%) of OGD-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, had no Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Note Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. Product Description UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM. It is ~27-fold selective against PARP1.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 5-phenacyloxy-2H-isoquinolin-1-one INCHI InChI=1S/C17H13NO3/c19-15(12-5-2-1-3-6-12)11-21-16-8-4-7-14-13(16)9-10-18-17(14)20/h1-10H,11H2,(H,18,20) InChi Key JJWMRRNGWSITSQ-UHFFFAOYSA-N Canonical SMILES C1=CC=C(C=C1)C(=O)COC2=CC=CC3=C2C=CNC3=O Isomeric SMILES C1=CC=C(C=C1)C(=O)COC2=CC=CC3=C2C=CNC3=O PubChem CID 25015515 Molecular Weight 279.29
Chemical and Physical Properties Solubility DMSO 56 mg/mL Water <1 mg/mL Ethanol <1 mg/mL Refractive Index 1.62 Boil Point(°C) ~570.3 °C at 760 mmHg Melt Point(°C) 166-168°C
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H302: Harmful if swallowed
Precautionary Statements P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P301+P317: IF SWALLOWED: Get medical help.
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E1712151