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URB597 - ≥98%, high purity , CAS No.546141-08-6, Inhibitor of Fatty acid amide hydrolase;Inhibitor of Fatty acid amide hydrolase-2;Activator of TRPA1

Moligand™
≥98%

CAS#: 546141-08-6
Formula: C₂₀H₂₂N₂O₃
Molecular Weight: 338.4
MDL number: MFCD05863934
PubChem CID: 1383884

Item Number

U126873

Grouped product items
SKU	Size	Availability	Price
U126873-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$35.90
U126873-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$147.90
U126873-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$395.90
U126873-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$891.90
U126873-500mg	500mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,005.90
U126873-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,207.90

Potent and selective FAAH inhibitor

View related series

Fatty acid amide hydrolase Inhibitor Fatty acid amide hydrolase-2 Inhibitor TRPA1 Activator

Basic Description

Synonyms	546141-08-6\|URB597\|URB-597\|3'-Carbamoyl-[1,1'-biphenyl]-3-yl cyclohexylcarbamate\|URB 597\|KDS-4103\|FAAH Inhibitor II\|[3-(3-carbamoylphenyl)phenyl] N-cyclohexylcarbamate\|C20H22N2O3\|Org-231295\|3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate\|PX47LB88FO\|CHEM
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Grade	Moligand™
Action Type	ACTIVATOR, INHIBITOR
Mechanism of action	Inhibitor of Fatty acid amide hydrolase;Inhibitor of Fatty acid amide hydrolase-2;Activator of TRPA1
Product Description	URB597 is a potent, orally bioavailable FAAH inhibitor with IC50 of 4.6 nM, with no activity on other cannabinoid-related targets. Phase 1. A cell permeable carbamate and potent inhibitor of fatty acid amide hydrolase (FAHH)

Associated Targets

FAAH2 Tchem Fatty-acid amide hydrolase 2 1 Activities

Discover Target: FAAH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FAAH Tchem Fatty-acid amide hydrolase 1 28 Activities

Discover Target: FAAH

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 2 Activities

Discover Target: TRPA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	[3-(3-carbamoylphenyl)phenyl] N-cyclohexylcarbamate
INCHI	InChI=1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24)
InChi Key	ROFVXGGUISEHAM-UHFFFAOYSA-N
Canonical SMILES	C1CCC(CC1)NC(=O)OC2=CC=CC(=C2)C3=CC(=CC=C3)C(=O)N
Isomeric SMILES	C1CCC(CC1)NC(=O)OC2=CC=CC(=C2)C3=CC(=CC=C3)C(=O)N
WGK Germany	3
PubChem CID	1383884
Molecular Weight	338.4

Wikipedia

CAS Registry No.

ChEMBL Ligand

PubChem CID

Certificates

Certificate of Analysis(COA)

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1 results found

Lot Number	Certificate Type	Date	Item
E1526076	Certificate of Analysis	Jan 14, 2023	U126873

Safety and Hazards(GHS)

Pictogram(s)	GHS09, GHS07
Hazard Statements	H319:Causes serious eye irritation H410:Very toxic to aquatic life with long lasting effects
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P501:Dispose of contents/container to ...
WGK Germany	3

References

1. Ahn K, Johnson DS, Fitzgerald LR, Liimatta M, Arendse A, Stevenson T, Lund ET, Nugent RA, Nomanbhoy TK, Alexander JP et al.. (2007) Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity.. Biochemistry, 46 (45): (13019-30). [PMID:17949010]
2. Wei BQ, Mikkelsen TS, McKinney MK, Lander ES, Cravatt BF. (2006) A second fatty acid amide hydrolase with variable distribution among placental mammals.. J Biol Chem, 281 (48): (36569-78). [PMID:17015445]

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