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URMC-099 - 96%, high purity , CAS No.1229582-33-5, Inhibitor of cyclin dependent kinase like 2;Inhibitor of death associated protein kinase 3;Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of leucine rich repeat kinase 2;Inhibitor of mitogen-activated protein kinase kinase kinase 10;Inhibit

Specifications & Purity: 96%

CAS#: 1229582-33-5
Formula: C₂₇H₂₇N₅
Molecular Weight: 421.54
PubChem CID: 54764565

Item Number

U275952

Grouped product items
SKU	Size	Availability	Price
U275952-5mg	5mg	In stock	$64.90
U275952-10mg	10mg	In stock	$97.90
U275952-25mg	25mg	In stock	$220.90
U275952-50mg	50mg	In stock	$293.90
U275952-100mg	100mg	In stock	$489.90

Novel bioavailable, brain penetrant MLK inhibitor

View related series

cyclin dependent kinase like 2 Inhibitor death associated protein kinase 3 Inhibitor fms related receptor tyrosine kinase 3 Inhibitor leucine rich repeat kinase 2 Inhibitor mitogen-activated protein kinase kinase kinase 10 Inhibitor mitogen-activated protein kinase kinase kinase 11 Inhibitor mitogen-activated protein kinase kinase kinase 2 Inhibitor mitogen-activated protein kinase kinase kinase 9 Inhibitor SRSF protein kinase 2 Inhibitor

Basic Description

Synonyms	3-(1H-Indol-5-yl)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-1Hpyrrolo[2,3-b]pyridine
Specifications & Purity	96%
Storage Temp	Store at -20°C,Argon charged
Shipped In	Dry ice
Action Type	INHIBITOR
Mechanism of action	Inhibitor of cyclin dependent kinase like 2;Inhibitor of death associated protein kinase 3;Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of leucine rich repeat kinase 2;Inhibitor of mitogen-activated protein kinase kinase kinase 10;Inhibit

Associated Targets

CDKL2 Tchem Cyclin-dependent kinase-like 2 0 Activities

Discover Target: CDKL2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DLK1 Tchem Protein delta homolog 1 2 Activities

Discover Target: DLK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DAPK3 Tchem Death-associated protein kinase 3 1 Activities

Discover Target: DAPK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SRPK2 Tchem SRSF protein kinase 2 0 Activities

Discover Target: SRPK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FLT3 Tclin Receptor-type tyrosine-protein kinase FLT3 2 Activities

Discover Target: FLT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TNIK Tchem TRAF2 and NCK-interacting protein kinase 1 Activities

Discover Target: TNIK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP3K10 Tchem Mitogen-activated protein kinase kinase kinase 10 1 Activities

Discover Target: MAP3K10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LRRK2 Tchem Leucine-rich repeat serine/threonine-protein kinase 2 2 Activities

Discover Target: LRRK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP3K11 Tchem Mitogen-activated protein kinase kinase kinase 11 2 Activities

Discover Target: MAP3K11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP3K2 Tchem Mitogen-activated protein kinase kinase kinase 2 1 Activities

Discover Target: MAP3K2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL1 2 Activities

Discover Target: ABL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP3K9 Tchem Mitogen-activated protein kinase kinase kinase 9 2 Activities

Discover Target: MAP3K9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-(1H-indol-5-yl)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridine
INCHI	InChI=1S/C27H27N5/c1-31-10-12-32(13-11-31)18-19-2-4-20(5-3-19)23-15-24-25(17-30-27(24)29-16-23)21-6-7-26-22(14-21)8-9-28-26/h2-9,14-17,28H,10-13,18H2,1H3,(H,29,30)
InChi Key	QKKIWEILHCXECO-UHFFFAOYSA-N
Canonical SMILES	CN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C(NC=C4C5=CC6=C(C=C5)NC=C6)N=C3
Isomeric SMILES	CN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C(NC=C4C5=CC6=C(C=C5)NC=C6)N=C3
PubChem CID	54764565
Molecular Weight	421.54

PubChem CID

54764565

ChEMBL Ligand

CHEMBL2436978

CAS Registry No.

1229582-33-5

Certificates

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5 results found

Lot Number	Certificate Type	Date	Item
I2222279	Certificate of Analysis	Jul 12, 2023	U275952
I2222280	Certificate of Analysis	Jul 12, 2023	U275952
I2222281	Certificate of Analysis	Jul 12, 2023	U275952
I2222282	Certificate of Analysis	Jul 12, 2023	U275952
I2222283	Certificate of Analysis	Jul 12, 2023	U275952

References

1. Goodfellow VS, Loweth CJ, Ravula SB, Wiemann T, Nguyen T, Xu Y, Todd DE, Sheppard D, Pollack S, Polesskaya O et al.. (2013) Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3.. J Med Chem, 56 (20): (8032-48). [PMID:24044867]

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