Urokinase expression and invasiveness suppression by urinary trypsin inhibitor acts through MEK/ERK/c-Jun-dependent signaling pathways
Storage Temp
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
Grade
EnzymoPure™
Product Description
Physical form Lyophilized from 1 mL of 50 mM Tris-HCl, pH 7.4 with 100 mM NaCl, 0.1% PEG 6000, and 200 mM mannitol Physical properties High molecular weight form migrating at 54 kDa by SDS-PAGE under non-reducing conditions Urokinase is a protease that cleaves plasminogen to form plasmin. It binds to cell surface receptors (uPAR) from which it regulates cell adhesion and migration during tissue remodeling and which also activate intracellular signaling pathways. Urokinase is composed of three domains: the amino terminal domain which is homologous to epidermal growth factor is attached through a central kringle domain to the protease domain in the carboxyl terminus.
1.Zhechang Chen, Caijie Yuan, Yaxin Ye, Bitao Lu, Enling Hu, Fei Lu, Kun Yu, Ruiqi Xie, Guangqian Lan. (2024) Dual-targeting fucoidan-based microvesicle for arterial thrombolysis and re-occlusion inhibition. CARBOHYDRATE POLYMERS, 328 (121703). [PMID:38220339][10.1016/j.carbpol.2023.121703]
2.Song Jianwen, Kang Xiaoying, Wang Lu, Ding Dan, Kong Deling, Li Wen, Qi Ji. (2023) Near-infrared-II photoacoustic imaging and photo-triggered synergistic treatment of thrombosis via fibrin-specific homopolymer nanoparticles. Nature Communications, 14 (1):(1-19). [PMID:37898604][10.1038/s41467-023-42691-8]
3.Weiwei Zhang, Yuguo Deng, Jinhao Zhao, Tao Zhang, Xiang Zhang, Wenping Song, Lin Wang, Tianlong Li. (2023) Amoeba-Inspired Magnetic Venom Microrobots. Small, 19 (23):(2207360). [PMID:36869412][10.1002/smll.202207360]
4.Mei Jian feng, Cai Shao fen, Yi Yu, Wang Xu dong, Ying Guo qing. (2023) Study of the fibrinolytic activity of serrapeptase and its in vitro thrombolytic effects. Brazilian Journal of Pharmaceutical Sciences, 58 (e201004). [PMID:][10.1590/s2175-97902022e201004]
5.Songzhi Xie, Shang Li, Wenxiong Cao, Chuanfei Mo, Zhanlin Zhang, Kun Huang, Xiaohong Li. (2022) Bacteria-Templated and Dual Enzyme-Powered Microcapsule Motors To Promote Thrombus Penetration and Thrombolytic Efficacy. ACS Applied Materials & Interfaces, 14 (33):(37553–37565). [PMID:35948498][10.1021/acsami.2c11213]
6.Dongya Wang, Qianqian Zhao, Jingcan Qin, Yuanyuan Guo, Chuan Zhang, Yuehua Li. (2022) Urokinase loaded black phosphorus nanosheets for sequential thrombolysis and reactive oxygen species scavenging in ischemic stroke treatment. Biomaterials Science, 10 (16):(4656-4666). [PMID:35801526][10.1039/D2BM00746K]
1.Zhechang Chen, Caijie Yuan, Yaxin Ye, Bitao Lu, Enling Hu, Fei Lu, Kun Yu, Ruiqi Xie, Guangqian Lan. (2024) Dual-targeting fucoidan-based microvesicle for arterial thrombolysis and re-occlusion inhibition. CARBOHYDRATE POLYMERS, 328 (121703). [PMID:38220339][10.1016/j.carbpol.2023.121703]
2.Song Jianwen, Kang Xiaoying, Wang Lu, Ding Dan, Kong Deling, Li Wen, Qi Ji. (2023) Near-infrared-II photoacoustic imaging and photo-triggered synergistic treatment of thrombosis via fibrin-specific homopolymer nanoparticles. Nature Communications, 14 (1):(1-19). [PMID:37898604][10.1038/s41467-023-42691-8]
3.Weiwei Zhang, Yuguo Deng, Jinhao Zhao, Tao Zhang, Xiang Zhang, Wenping Song, Lin Wang, Tianlong Li. (2023) Amoeba-Inspired Magnetic Venom Microrobots. Small, 19 (23):(2207360). [PMID:36869412][10.1002/smll.202207360]
4.Mei Jian feng, Cai Shao fen, Yi Yu, Wang Xu dong, Ying Guo qing. (2023) Study of the fibrinolytic activity of serrapeptase and its in vitro thrombolytic effects. Brazilian Journal of Pharmaceutical Sciences, 58 (e201004). [PMID:][10.1590/s2175-97902022e201004]
5.Songzhi Xie, Shang Li, Wenxiong Cao, Chuanfei Mo, Zhanlin Zhang, Kun Huang, Xiaohong Li. (2022) Bacteria-Templated and Dual Enzyme-Powered Microcapsule Motors To Promote Thrombus Penetration and Thrombolytic Efficacy. ACS Applied Materials & Interfaces, 14 (33):(37553–37565). [PMID:35948498][10.1021/acsami.2c11213]
6.Dongya Wang, Qianqian Zhao, Jingcan Qin, Yuanyuan Guo, Chuan Zhang, Yuehua Li. (2022) Urokinase loaded black phosphorus nanosheets for sequential thrombolysis and reactive oxygen species scavenging in ischemic stroke treatment. Biomaterials Science, 10 (16):(4656-4666). [PMID:35801526][10.1039/D2BM00746K]
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