Utomilumab (anti-TNFRSF9) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to TNFRSF9, >95%, high purity, Human IgG2SA, Antibody of 4-1BB
Utomilumab (anti-TNFRSF9) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to TNFRSF9, >95%, high purity, Human IgG2SA, Antibody of 4-1BB
Utomilumab (anti-TNFRSF9) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to TNFRSF9, >95%, high purity, Human IgG2SA
PurityUtomilumab is a humanized IgG2 mAb agonist that targets the T-cell co-stimulatory receptor 4-1BB/CD137. Utomilumab can be used in relapsed/refractory follicular lymphoma (FL) and other CD20+ non-Hodgkin lymphoma (NHL) studies. >95% (SDS-PAGE&SEC) Endotoxin Level < 1.0EU/mg
Product Properties
Antibody Type
Primary antibody
Clonality
Recombinant
Isotype
Human IgG2SA
Light Chain Type
lambdaC2
SDS-PAGE
28.6 kDa (Light Chain) & 51.9 kDa (Heavy Chain), under reducing conditions; 171.1 kDa, under non-reducing conditions.
Purification Method
Protein A purified
Purity
>95%
Source
CHO supernatant
Form
Liquid
Concentration
See COA
Storage Temp
Store at -80°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS
1417318-27-4
Images
Utomilumab (anti-TNFRSF9) (Ab170652) - ELISA Immobilized Human TNFRSF9/ 4-1BB/ CD137-his at 2.0 μg/mL can bind Utomilumab (anti-TNFRSF9) (Ab170652) with the EC₅₀ of 6.92 ng/mL.
Utomilumab (anti-TNFRSF9) (Ab170652) - SEC The purity of Utomilumab (anti-TNFRSF9) (Ab170652) is more than 95% verified by HPLC.
Associated Targets(Human)
TNFRSF9TbioTumor necrosis factor receptor superfamily member 9 (0 Activities)
1.Fisher TS, Kamperschroer C, Oliphant T, Love VA, Lira PD, Doyonnas R, Bergqvist S, Baxi SM, Rohner A, Shen AC et al.. (2012) Targeting of 4-1BB by monoclonal antibody PF-05082566 enhances T-cell function and promotes anti-tumor activity.. Cancer Immunol Immunother, 61 (10):(1721-33). [PMID:22406983][10.1021/op500134e]
2.Mittal P, Abblett R, Ryan JM, Hagymasi AT, Agyekum-Yamoah A, Svedova J, Reiner SL, St Rose MC, Hanley MP, Vella AT et al.. (2018) An Immunotherapeutic CD137 Agonist Releases Eomesodermin from ThPOK Repression in CD4 T Cells.. J Immunol, 200 (4):(1513-1526). [PMID:29305435][10.1021/op500134e]
3.Zhou, Z Z and 6 more authors.. (1995) Characterization of human homologue of 4-1BB and its ligand.. Immunology letters, [PMID:7622190]
4.Alderson, M R MR and 9 more authors.. (1994) Molecular and biological characterization of human 4-1BB and its ligand.. European journal of immunology, [PMID:8088337]
5.Schwarz, H H, Tuckwell, J J and Lotz, M M.. (1993) A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family.. Gene, (8):[PMID:8262389]
6.Jang, L K LK and 5 more authors.. (2001) A novel leucine-rich repeat protein (LRR-1): potential involvement in 4-1BB-mediated signal transduction.. Molecules and cells, (31):[PMID:11804328]
7.Saoulli, K K and 10 more authors.. (1998) CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand.. The Journal of experimental medicine, (1):[PMID:9607925]
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