RXR antagonist; displays high RXR binding affinity. Does not affect the corepressor interaction capacity of the RARαsubunit within the context of the RAR-RXR heterodimer.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
ANTAGONIST
Mechanism of action
Antagonist of Retinoid X receptor-α;Antagonist of Retinoid X receptor-β
Product Description
product description：
UVI 3003 is a highly selective antagonist of retinoid X receptor (RXR), and inhibits xenopus and human RXRα with IC50 of 0.22 μM and 0.24 μM in Cos7 cells, respectively.
1.Pérez Santín E, Germain P, Quillard F, Khanwalkar H, Rodríguez-Barrios F, Gronemeyer H, de Lera AR, Bourguet W. (2009) Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers.. J Med Chem, 52 (10):(3150-8). [PMID:19408900][10.1021/op500134e]
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B2418649