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UVI 3003 - ≥98%(HPLC), high purity , CAS No.847239-17-2, Antagonist of Retinoid X receptor-α;Antagonist of Retinoid X receptor-β

Moligand™
≥98%(HPLC)

CAS#: 847239-17-2
Formula: C₂₈H₃₆O₄
Molecular Weight: 436.58
PubChem CID: 44566108

Item Number

U287111

Grouped product items
SKU	Size	Availability	Price
U287111-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$20.90
U287111-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$86.90
U287111-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$162.90
U287111-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$652.90

RXR antagonist

View related series

Retinoid X receptor-α Antagonist Retinoid X receptor-β Antagonist

Basic Description

Synonyms	UVI 3003\|847239-17-2\|UVI3003\|UVI-3003\|(2E)-3-{4-hydroxy-3-[5,5,8,8-tetramethyl-3-(pentyloxy)-5,6,7,8-tetrahydronaphthalen-2-yl]phenyl}prop-2-enoic acid\|(E)-3-(4-hydroxy-3-(5,5,8,8-tetramethyl-3-(pentyloxy)-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl)acrylic
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	RXR antagonist; displays high RXR binding affinity. Does not affect the corepressor interaction capacity of the RARαsubunit within the context of the RAR-RXR heterodimer.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of Retinoid X receptor-α;Antagonist of Retinoid X receptor-β
Product Description	product description： UVI 3003 is a highly selective antagonist of retinoid X receptor (RXR), and inhibits xenopus and human RXRα with IC50 of 0.22 μM and 0.24 μM in Cos7 cells, respectively.

Associated Targets

RXRB Tclin Retinoic acid receptor RXR-beta 0 Activities

Discover Target: RXRB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RXRA Tclin Retinoic acid receptor RXR-alpha 0 Activities

Discover Target: RXRA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RARA Tclin Retinoic acid receptor alpha 0 Activities

Discover Target: RARA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(E)-3-[4-hydroxy-3-(5,5,8,8-tetramethyl-3-pentoxy-6,7-dihydronaphthalen-2-yl)phenyl]prop-2-enoic acid
INCHI	InChI=1S/C28H36O4/c1-6-7-8-15-32-25-18-23-22(27(2,3)13-14-28(23,4)5)17-21(25)20-16-19(9-11-24(20)29)10-12-26(30)31/h9-12,16-18,29H,6-8,13-15H2,1-5H3,(H,30,31)/b12-10+
InChi Key	APJSHECCIRQQDV-ZRDIBKRKSA-N
Canonical SMILES	CCCCCOC1=CC2=C(C=C1C3=C(C=CC(=C3)C=CC(=O)O)O)C(CCC2(C)C)(C)C
Isomeric SMILES	CCCCCOC1=CC2=C(C=C1C3=C(C=CC(=C3)/C=C/C(=O)O)O)C(CCC2(C)C)(C)C
PubChem CID	44566108
Molecular Weight	436.58

PubChem CID

44566108

ChEMBL Ligand

CHEMBL521955

CAS Registry No.

847239-17-2

Certificates

Certificate of Analysis(COA)

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8 results found

Lot Number	Certificate Type	Date	Item
B2418649	Certificate of Analysis	Jan 06, 2024	U287111
B2418650	Certificate of Analysis	Jan 06, 2024	U287111
B2418651	Certificate of Analysis	Jan 06, 2024	U287111
B2418673	Certificate of Analysis	Jan 06, 2024	U287111
B2418674	Certificate of Analysis	Jan 06, 2024	U287111
B2418675	Certificate of Analysis	Jan 06, 2024	U287111
B2418676	Certificate of Analysis	Jan 06, 2024	U287111
B2418677	Certificate of Analysis	Jan 06, 2024	U287111

References

1. Pérez Santín E, Germain P, Quillard F, Khanwalkar H, Rodríguez-Barrios F, Gronemeyer H, de Lera AR, Bourguet W. (2009) Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers.. J Med Chem, 52 (10): (3150-8). [PMID:19408900]

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