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Vallesiachotamine , CAS No.5523-37-5
Alkaloids Indole Alkaloids
Basic Description Biochemical and Physiological Mechanisms Vallesiachotamine, a known monoterpene indole alkaloid, possesses anti-tumor activity. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description Vallesiachotamine, a known monoterpene indole alkaloid, possesses anti-tumor activity.
In Vitro
Vallesiachotamine induces G0/G1 arrest and increased the proportion of sub-G1 hypodiploid cells (at 11 μM and 22 μM) and this effect is not dependent on time of incubation. Vallesiachotamine acts by promoting G0/G1 cell cycle arrest, apoptosis and necrosis. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name methyl (2S,12bS)-2-[(E)-1-oxobut-2-en-2-yl]-1,2,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine-3-carboxylate INCHI InChI=1S/C21H22N2O3/c1-3-13(12-24)16-10-19-20-15(14-6-4-5-7-18(14)22-20)8-9-23(19)11-17(16)21(25)26-2/h3-7,11-12,16,19,22H,8-10H2,1-2H3/b13-3-/t16-,19-/m0/s1 InChi Key NTVLUSJWJRSPSM-JXSBNBLESA-N Canonical SMILES CC=C(C=O)C1CC2C3=C(CCN2C=C1C(=O)OC)C4=CC=CC=C4N3 Isomeric SMILES C/C=C(/C=O)\[C@@H]1C[C@H]2C3=C(CCN2C=C1C(=O)OC)C4=CC=CC=C4N3 PubChem CID 5384527 NSC Number 338699 MeSH Entry Terms vallesiachotamine Molecular Weight 350.41
Citations of This Product 1. Jianhua Zhu, Shuijie He, Pengfei Zhou, Jiachen Zi, Jincai Liang, Liyan Song, Rongmin Yu. (2018) Eliciting Effect of Catharanthine on the Biosynthesis of Vallesiachotamine and Isovallesiachotamine in Catharanthus roseus Cambial Meristematic Cells. Natural Product Communications, [PMID: [10.1177/1934578X1801300508 ]
References 1. Jianhua Zhu, Shuijie He, Pengfei Zhou, Jiachen Zi, Jincai Liang, Liyan Song, Rongmin Yu. (2018) Eliciting Effect of Catharanthine on the Biosynthesis of Vallesiachotamine and Isovallesiachotamine in Catharanthus roseus Cambial Meristematic Cells. Natural Product Communications, [PMID: [10.1177/1934578X1801300508 ]
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