Vantictumab (anti-FZD) - Primary antibody, specific to FZD, >95%, high purity, Human IgG2, Antibody of FZD 1;Antibody of FZD 2;Antibody of FZD 5;Antibody of FZD 7;Antibody of FZD 8
Vantictumab (anti-FZD) - Primary antibody, specific to FZD, >95%, high purity, Human IgG2, Antibody of FZD 1;Antibody of FZD 2;Antibody of FZD 5;Antibody of FZD 7;Antibody of FZD 8
Antibody of FZD 1;Antibody of FZD 2;Antibody of FZD 5;Antibody of FZD 7;Antibody of FZD 8
Product Description
Vantictumab (anti-FZD) is a monoclonal antibody targeting the Wnt signaling pathway with potential antineoplastic activity. Vantictumab (anti-FZD) binds to certain receptors in the Wnt signaling pathway thereby preventing the activation of the Wnt signaling pathway. This results in an inhibition of cancer stem cell (CSC) activity and a subsequent inhibition of cancer cell proliferation.
Product Properties
Isotype
Human IgG2
Light Chain Type
lambda
SDS-PAGE
143.16 kDa
Purification Method
Protein A purified
Purity
>95%
Form
Liquid
Concentration
Lot by Lot
Storage Temp
Store at -80°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS
1345009-45-1
Images
Vantictumab (anti-FZD) (Ab175695) - Flow Cytometry Flow Cytometry analysis of A549 cells labelling FZD (red) with Vantictumab (anti-FZD) (Ab175695). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Vantictumab (anti-FZD) (Ab175695) - SEC The purity of Vantictumab (anti-FZD) (Ab175695) is more than 95% verified by HPLC.
1.Katoh M, Katoh M. (2007) WNT signaling pathway and stem cell signaling network.. Clin Cancer Res, 13 (14):(4042-5). [PMID:17634527][10.1021/op500134e]
2.Gurney A, Axelrod F, Bond CJ, Cain J, Chartier C, Donigan L, Fischer M, Chaudhari A, Ji M, Kapoun AM et al.. (2012) Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors.. Proc Natl Acad Sci USA, 109 (29):(11717-22). [PMID:22753465][10.1021/op500134e]
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