Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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V129433-1mg | 1mg | In stock | $31.90 | |
V129433-5mg | 5mg | In stock | $129.90 | |
V129433-10mg | 10mg | In stock | $205.90 | |
V129433-25mg | 25mg | In stock | $463.90 | |
V129433-50mg | 50mg | In stock | $510.90 |
Synonyms | 4,6-Quinazolinediamine, N(sup 4)-(3-chloro-4-(2-thiazolylmethoxy)phenyl)-N(sup 6)-((4R)-4,5- dihydro-4-methyl-2-oxazolyl)- | (R)-N4-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)-N6-(4-methyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine | D70122 | AKOS0272508 |
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Specifications & Purity | Moligand™, ≥96% |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Receptor protein-tyrosine kinase erbB-2 inhibitor |
ALogP | 4.2 |
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Pubchem Sid | 488200911 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488200911 |
IUPAC Name | 4-N-[3-chloro-4-(1,3-thiazol-2-ylmethoxy)phenyl]-6-N-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]quinazoline-4,6-diamine |
INCHI | InChI=1S/C22H19ClN6O2S/c1-13-10-31-22(27-13)29-14-2-4-18-16(8-14)21(26-12-25-18)28-15-3-5-19(17(23)9-15)30-11-20-24-6-7-32-20/h2-9,12-13H,10-11H2,1H3,(H,27,29)(H,25,26,28)/t13-/m1/s1 |
InChi Key | UWXSAYUXVSFDBQ-CYBMUJFWSA-N |
Canonical SMILES | CC1COC(=N1)NC2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=NC=CS5)Cl |
Isomeric SMILES | C[C@@H]1COC(=N1)NC2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=NC=CS5)Cl |
PubChem CID | 42642648 |
Molecular Weight | 466.94 |
CAS Registry No. | 845272-21-1 |
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PubChem CID | 42642648 |
ChEMBL Ligand | CHEMBL2103842 |
PubChem SID | 488200911 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
D23211111 | Certificate of Analysis | Mar 21, 2023 | V129433 |
D23211122 | Certificate of Analysis | Mar 21, 2023 | V129433 |
D23211125 | Certificate of Analysis | Mar 21, 2023 | V129433 |
D23211145 | Certificate of Analysis | Mar 21, 2023 | V129433 |
D23211149 | Certificate of Analysis | Mar 21, 2023 | V129433 |
D23211151 | Certificate of Analysis | Mar 21, 2023 | V129433 |
D23211157 | Certificate of Analysis | Mar 21, 2023 | V129433 |
D23211165 | Certificate of Analysis | Mar 21, 2023 | V129433 |
D23211169 | Certificate of Analysis | Mar 21, 2023 | V129433 |
D23211246 | Certificate of Analysis | Mar 21, 2023 | V129433 |
Solubility | DMSO 6 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
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Pictogram(s) | GHS09, GHS07 |
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Signal | Warning |
Hazard Statements | H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P391:Collect spillage. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P319:Get medical help if you feel unwell. |