Vatalanib (PTK787) 2HCl - ≥99%, high purity , CAS No.212141-51-0

1 Citations

Item Number

V125857

Grouped product items
SKU	Size	Availability	Price
V125857-10mg	10mg	In stock	$58.90
V125857-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$82.90
V125857-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$373.90
V125857-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,344.90

Cell-permeable, potent, selective VEGFR tyrosine kinase inhibitor

Basic Description

Synonyms	Vatalanib dihydrochloride \| 212141-51-0 \| Vatalanib (PTK787) 2HCl \| Vatalanib 2HCl \| N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine dihydrochloride \| Vatalanib HCl \| PTK/ZK \| CGP-79787D \| DTXSID5049073 \| Vatalanib (dihydrochloride) \| NCGC00181350-02 \| N-(4-Chlorop
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Vatalanib (PTK787) is a novel VEGFR and c-Kit tyrosine kinases and angiogenesis inhibitor with IC50 of 0.037, 0.077, 0.27 and 0.73 μM for KDR, Flt-1, Flk and c-Kit, respectively.Cell-permeable, potent, selective inhibitor of the VEGFR tyrosine kinases\
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Vatalanib dihydrochloride (PTK787 dihydrochloride) is an inhibitor of VEGFR2/KDR with IC50 of 37 nM.

Associated Targets(Human)

YES1 Tclin Tyrosine-protein kinase YES (2781 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine;dihydrochloride
INCHI	InChI=1S/C20H15ClN4.2ClH/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14;;/h1-12H,13H2,(H,23,25);2*1H
InChi Key	AZUQEHCMDUSRLH-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4.Cl.Cl
Isomeric SMILES	C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4.Cl.Cl
Alternate CAS	212141-54-3
PubChem CID	22386467
Molecular Weight	419.74

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4 results found

Lot Number	Certificate Type	Date	Item
I2117148	Certificate of Analysis	Jul 07, 2023	V125857
I2117149	Certificate of Analysis	Jul 07, 2023	V125857
I2117491	Certificate of Analysis	Jul 07, 2023	V125857
I2117492	Certificate of Analysis	Jul 07, 2023	V125857

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Basic Description