VE-821 - ≥98%, high purity , CAS No.1232410-49-9, Inhibitor of ATR serine/threonine kinase

Item Number

V125220

• Synonyms: VE-821 | 1232410-49-9 | 3-Amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide | VE 821 | VE821 | 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide | CHEMBL1766779 | 3-amino-6-(4-methylsulfonylphenyl)-N-phenylpyrazine-2-carboxamide | BF884T
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: VE-821 is a novel ATR inhibitor. VE-821, sensitises tumour cells to DNA damage induced by radiation or chemotoxic drugs, by disrupting the DNA damage checkpoint and inhibiting DNA repair.Potent, selective ATP competitive ATR inhibitor (K i\xa0= 13 nM). Ex
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of ATR serine/threonine kinase
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM in cell-free assays, shows inhibition of H2AX phosphorylation, minimal activity against PIKKs ATM, DNA-PK, mTOR and PI3Kγ.