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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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V275789-1mg | 1mg | In stock | $105.90 | |
V275789-5mg | 5mg | In stock | $462.90 | |
V275789-10mg | 10mg | In stock | $878.90 | |
V275789-25mg | 25mg | In stock | $1,959.90 | |
V275789-50mg | 50mg | In stock | $3,528.90 |
Highly selective, cell-permeable indolin-2-one class receptor tyrosine kinase (RTK) inhibitor for vascular endothelial growth factor receptor 2 (VEGF-R2; KDR/Flk-1).
Synonyms | 15966-93-5 | VEGF Receptor 2 Kinase Inhibitor I | VEGFR2 Kinase Inhibitor I | SU5408 | Vegfr 2 kinase inhibitor I | Vegfr-2 inhi | CHEMBL86943 | U07H877HUF | ethyl 2,4-dimethyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrole-3-carboxylate | SU 5408 | VEGFR2 kinase inhibi |
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Specifications & Purity | Moligand™, ≥98%, (including isomers) |
Biochemical and Physiological Mechanisms | Highly selective, cell-permeable inhibitor of VEGFR2 kinase. Little or no effect against receptors for platelet-derived growth factor, epidermal growth factor, or insulin-like growth factor. |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of kinase insert domain receptor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
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IUPAC Name | ethyl 2,4-dimethyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrole-3-carboxylate |
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INCHI | InChI=1S/C18H18N2O3/c1-4-23-18(22)16-10(2)15(19-11(16)3)9-13-12-7-5-6-8-14(12)20-17(13)21/h5-9,19H,4H2,1-3H3,(H,20,21)/b13-9- |
InChi Key | PMUJUSJUVIXDQC-LCYFTJDESA-N |
Canonical SMILES | CCOC(=O)C1=C(NC(=C1C)C=C2C3=CC=CC=C3NC2=O)C |
Isomeric SMILES | CCOC(=O)C1=C(NC(=C1C)/C=C\2/C3=CC=CC=C3NC2=O)C |
PubChem CID | 6419834 |
Molecular Weight | 310.3 |
PubChem CID | 6419834 |
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ChEMBL Ligand | CHEMBL86943 |
CAS Registry No. | 15966-93-5 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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H2224377 | Certificate of Analysis | Jun 07, 2023 | V275789 |
H2224380 | Certificate of Analysis | Jun 07, 2023 | V275789 |
H2224381 | Certificate of Analysis | Jun 07, 2023 | V275789 |
H2224317 | Certificate of Analysis | Jun 07, 2023 | V275789 |
H2224318 | Certificate of Analysis | Jun 07, 2023 | V275789 |
Solubility | Soluble in DMSO and in ethanol |
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1. Sun L, Tran N, Tang F, App H, Hirth P, McMahon G, Tang C. (1998) Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases.. J Med Chem, 41 (14): (2588-603). [PMID:9651163] |
2. He L et al.. (2019) Parenchymal and stromal tissue regeneration of tooth organ by pivotal signals reinstated in decellularized matrix.. Nat Mater, 18 (6): (627-637). [PMID:31114073] |