VEGFR2 kinase inhibitor IV - ≥95%, high purity , CAS No.216661-57-3, Inhibitor of kinase insert domain receptor

Item Number

V338295

• Synonyms: 216661-57-3 | KDR/Flk-1 Kinase Inhibitor IV | pyrazolo[1,5-a]pyrimidine 3g | Vegf 2 kinase inhibitor IV | VEGF Receptor 2 Kinase Inhibitor IV | FHX0K077F6 | Pyrazolo[1,5-a]pyrimidine, 6-(4-methoxyphenyl)-3-(3-thienyl)- | VEGFR2 KINASE INHIBITOR IV | UNII-FHX0K077F6 | CHEMB
• Specifications & Purity: Moligand™, ≥95%
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of kinase insert domain receptor

Product Description

VEGFR2 Kinase Inhibitor IV is a 3,6-diaryl substituted pyrazolopyrimidine that acts as a potent, ATP-competitive inhibitor of Flk-1 (VEGFR-2/KDR ; IC|50|= 19 nM). The compound displays ~2-fold greater selectivity for VEGFR-2 over PDGFRb (IC|50|= 34 nM) and 10-fold greater selectivity over VEGFR-1 (Flt-1) and VEGFR-3 (Flt-4; IC|50|= 190 nM) tyrosine kinase activity. VEGFR2 Kinase Inhibitor IV does not inhibit FGFR-1 or Src kinase activity (IC|50|> 1.9 μM). The chemical has been shown to inhibit VEGF-stimulated mitogenesis in human umbilical vein endothelial cells (IC|50|= 387 nM). VEGFR2 Kinase Inhibitor IV also inhibits Flt3 phosphorylation in Flt3/Itd-BaF3 cells.