Veliparib is a potent inhibitor of both PARP-1 and PARP-2 by [3H]NAD+ with Kis of 5.2 and 2.9 nmol/L, respectively.
Storage Temp
Store at 2-8°C
Shipped In
Wet ice
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
PARP 1, 2 and 3 inhibitor
Product Description
Veliparib is a potent PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition. A potent PARP-1/-2 inhibitor shown to potentiate DNA damaging agents
1.Rugo HS, Olopade OI, DeMichele A, Yau C, van 't Veer LJ, Buxton MB, Hogarth M, Hylton NM, Paoloni M, Perlmutter J et al.. (2016) Adaptive Randomization of Veliparib-Carboplatin Treatment in Breast Cancer.. N Engl J Med, 375 (1):(23-34). [PMID:27406347][10.1021/op500134e]
2.Buisson R, Dion-Côté AM, Coulombe Y, Launay H, Cai H, Stasiak AZ, Stasiak A, Xia B, Masson JY. (2010) Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination.. Nat Struct Mol Biol, 17 (10):(1247-54). [PMID:20871615][10.1021/op500134e]
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D1513158