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Veliparib - ≥99%, high purity , PARP 1, 2 and 3 inhibitor, CAS No.912444-00-9, PARP 1, 2 and 3 inhibitor

Moligand™
≥99%

CAS#: 912444-00-9
Formula: C₁₃H₁₆N₄O
Molecular Weight: 244.3
PubChem CID: 11960529

Item Number

V127105

Grouped product items
SKU	Size	Availability	Price
V127105-10mg	10mg	In stock	$90.90
V127105-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$260.90
V127105-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,174.90

Basic Description

Synonyms	Veliparib\|912444-00-9\|ABT-888\|ABT 888\|ABT-888 (Veliparib)\|Veliparib free base\|(R)-2-(2-methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide\|ABT888\|2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide\|2-[(2R)-2-methyl-2-pyrrolidinyl]-1H-ben
Specifications & Purity	≥99%
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	PARP 1, 2 and 3 inhibitor
Product Description	Veliparib is a potent PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition. A potent PARP-1/-2 inhibitor shown to potentiate DNA damaging agents

Associated Targets

PARP1 Tclin Poly [ADP-ribose] polymerase 1 27 Activities

Discover Target: PARP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PARP2 Tclin Poly [ADP-ribose] polymerase 2 9 Activities

Discover Target: PARP2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide
INCHI	InChI=1S/C13H16N4O/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17)/t13-/m1/s1
InChi Key	JNAHVYVRKWKWKQ-CYBMUJFWSA-N
Canonical SMILES	CC1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N
Isomeric SMILES	C[C@@]1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N
PubChem CID	11960529
Molecular Weight	244.3

CAS Registry No.

PubChem CID

ChEMBL Ligand

DrugBank Ligand

Wikipedia

RCSB PDB Ligand

Certificates

Certificate of Analysis(COA)

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2 results found

Lot Number	Certificate Type	Date	Item
D1513158	Certificate of Analysis	Nov 15, 2022	V127105
J2324010	Certificate of Analysis	Nov 15, 2022	V127105

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Warning
Hazard Statements	H341:Suspected of causing genetic defects H373:Causes damage to organs through prolonged or repeated exposure H302:Harmful if swallowed H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P281:Use personal protective equipment as required. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell.

References

1. Rugo HS, Olopade OI, DeMichele A, Yau C, van 't Veer LJ, Buxton MB, Hogarth M, Hylton NM, Paoloni M, Perlmutter J et al.. (2016) Adaptive Randomization of Veliparib-Carboplatin Treatment in Breast Cancer.. N Engl J Med, 375 (1): (23-34). [PMID:27406347]
2. Buisson R, Dion-Côté AM, Coulombe Y, Launay H, Cai H, Stasiak AZ, Stasiak A, Xia B, Masson JY. (2010) Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination.. Nat Struct Mol Biol, 17 (10): (1247-54). [PMID:20871615]

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