Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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V303890-100mg | 100mg | In stock | $93.90 | |
V303890-250mg | 250mg | In stock | $153.90 | |
V303890-1g | 1g | In stock | $383.90 |
Synonyms | 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile | 5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile | Spectrum2_001740 | Verelan | Lekoptin | alpha-(3-((2-(3,4-Di |
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Specifications & Purity | Moligand™, ≥98% |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | CHANNEL BLOCKER, GATING INHIBITOR, INHIBITOR |
Mechanism of action | Channel blocker of Ca v1.1;Channel blocker of Ca v1.2;Gating inhibitor of Ca v1.2;Channel blocker of Ca v1.3;Channel blocker of Ca v1.4;Inhibitor of CYP3A4;Gating inhibitor of K ir3.2;Channel blocker of K v1.7;Channel blocker of K v1.8;Channel blocker of |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile |
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INCHI | InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3 |
InChi Key | SGTNSNPWRIOYBX-UHFFFAOYSA-N |
Canonical SMILES | CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC |
Isomeric SMILES | CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC |
PubChem CID | 2520 |
Molecular Weight | 454.6 |
PubChem CID | 2520 |
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ChEBI | CHEBI:9948 |
CAS Registry No. | 52-53-9 |
Wikipedia | Verapamil |
DrugBank Ligand | DB00661 |
BindingDB Ligand | 50279753 |
ChEMBL Ligand | CHEMBL6966 |
PEP | verapamil |
Antibiotic DB | 1429 |
DrugCentral Ligand | 2815 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
E2410255 | Certificate of Analysis | May 17, 2024 | V303890 |
E2410374 | Certificate of Analysis | May 17, 2024 | V303890 |
D2426085 | Certificate of Analysis | Jul 14, 2023 | V303890 |
F23271471 | Certificate of Analysis | Jul 14, 2023 | V303890 |
F23271472 | Certificate of Analysis | Jul 14, 2023 | V303890 |
F23271473 | Certificate of Analysis | Jul 14, 2023 | V303890 |
F23271475 | Certificate of Analysis | Jul 14, 2023 | V303890 |
F23271479 | Certificate of Analysis | Jul 14, 2023 | V303890 |
F23271480 | Certificate of Analysis | Jul 14, 2023 | V303890 |
C2219461 | Certificate of Analysis | May 30, 2022 | V303890 |
C2219462 | Certificate of Analysis | May 30, 2022 | V303890 |
C2219467 | Certificate of Analysis | May 30, 2022 | V303890 |
D2318961 | Certificate of Analysis | May 30, 2022 | V303890 |
Boil Point(°C) | 243-246 ºC |
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Melt Point(°C) | 25°C |
Pictogram(s) | GHS06 |
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Signal | Danger |
Hazard Statements | H301:Toxic if swallowed H311:Toxic in contact with skin H331:Toxic if inhaled |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P361+P364:Take off immediately all contaminated clothing and wash it before reuse. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P316:Get emergency medical help immediately. |
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2. Yu Wang, Yao Yu, Yi-Ping Hou, Xue-Wei Mao, Zong-Liang Liu, Jian Cui, Bi Wang, Shu Xu, Yi-Yun Qian, Yan-Qin Jiang, Min Wei, Ping-Ping Song. (2023) Crucial Role of the Ca2+/CN Signaling Pathway in the Antifungal Activity of Seselin against Botrytis cinerea. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (25): (9772–9781). [PMID:37313981] |
3. Lan Tang, Kaijuan Huang, Wenhui Jiang, Lulu Fu, Ran Zhang, Liting Shen, Zhimin Ou, Ye Huang, Zhenhai Zhang. (2023) Exploration of the inhibition action of TPGS on tumor cells and its combined use with chemotherapy drugs. DRUG DELIVERY, 30 (1): (2183830). [PMID:36852689] |
4. Bin Jiao, Huimin Ye, Xinwei Liu, Jiexun Bu, Junhan Wu, Wenpeng Zhang, Yunfeng Zhang, Zheng Ouyang. (2021) Handheld Mass Spectrometer with Intelligent Adaptability for On-Site and Point-of-Care Analysis. ANALYTICAL CHEMISTRY, 93 (47): (15607–15616). [PMID:34780167] |
5. Yuqin Zhou, Weitong Hu, Xiangli Zhang, Yi Wang, Wenya Zhuang, Fengzhi Li, Qingyong Li. (2021) Cellular Uptake and Transport Characteristics of FL118 Derivatives in Caco-2 Cell Monolayers. CHEMICAL & PHARMACEUTICAL BULLETIN, 69 (11): (1054-1060). [PMID:34719586] |
6. Xiaoyu Lu, Hangyi Wu, Yiping Liang, Zhenhai Zhang, HuiXia Lv. (2021) Redox-responsive prodrug for improving oral bioavailability of paclitaxel through bile acid transporter-mediated pathway. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 600 (120496). [PMID:33746013] |
7. Li Sinai, Liu Hongxu, Li Yue, Qin Xiaomei, Li Mengjie, Shang Juju, Xing Wenlong, Gong Yanbing, Liu Weihong, Zhou Mingxue. (2021) Shen-Yuan-Dan Capsule Attenuates Verapamil-Induced Zebrafish Heart Failure and Exerts Antiapoptotic and Anti-Inflammatory Effects via Reactive Oxygen Species–Induced NF-κB Pathway. Frontiers in Pharmacology, 12 [PMID:33732158] |
8. Songhui Zhou, Ruicheng Wang, Hong Xiao. (2020) Adipocytes induce the resistance of ovarian cancer to carboplatin through ANGPTL4. ONCOLOGY REPORTS, 44 (3): (927-938). [PMID:32705217] |
9. Renjie Xu, Hongdan Zhu, Lingmin Hu, Beimeng Yu, Xiaohua Zhan, Yichu Yuan, Ping Zhou. (2020) Characterization of the intestinal absorption of morroniside from Cornus officinalis Sieb. et Zucc via a Caco-2 cell monolayer model. PLoS One, 15 (5): (e0227844). [PMID:32470043] |
10. Zhao Li, Tingwei Cai, Yao Qin, Yunhua Zhang, Ruoheng Jin, Kaikai Mao, Xun Liao, Hu Wan, Jianhong Li. (2020) Transcriptional Response of ATP-Binding Cassette (ABC) Transporters to Insecticide in the Brown Planthopper, Nilaparvata lugens (Stål). Insects, 11 (5): (280). [PMID:32370222] |
11. Can Wu, Nani Wang, Pingcui Xu, Xuping Wang, Dan Shou, Yan Zhu. (2020) Preparation and application of polyvinyl alcohol-decorated cell membrane chromatography for screening anti-osteoporosis components from Liuwei Dihuang decoction-containing serum. JOURNAL OF SEPARATION SCIENCE, 43 (11): (2105-2114). [PMID:32135026] |
12. Yonghong Miao, Xiaoxue Sun, Guojun Gao, Xianglei Jia, Hao Wu, Ying Chen, Liyong Huang. (2019) Evaluation of (-)-epigallocatechin-3-gallate (EGCG)-induced cytotoxicity on astrocytes: A potential mechanism of calcium overloading-induced mitochondrial dysfunction. TOXICOLOGY IN VITRO, 61 (104592). [PMID:31356857] |
13. Weng Qi, Zhou Leilei, Xia Lihua, Zheng Yixin, Zhang Xiangli, Li Fengzhi, Li Qingyong. (2019) In vitro evaluation of FL118 and 9-Q20 cytotoxicity and cellular uptake in 2D and 3D different cell models. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 84 (3): (527-537). [PMID:31030236] |
14. Renjie Xu, Yichu Yuan, Jia Qi, Jia Zhou, Xiaowen Guo, Jian Zhang, Ruanjuan Zhan. (2018) Elucidation of the Intestinal Absorption Mechanism of Loganin in the Human Intestinal Caco-2 Cell Model. Evidence-based Complementary and Alternative Medicine, 2018 (8340563). [PMID:30671130] |
15. Ying Chen, Jianjun Chen, Xiaoxue Sun, Xiaoxiao Shi, Lei Wang, Liyong Huang, Wenke Zhou. (2018) Evaluation of the neuroprotective effect of EGCG: a potential mechanism of mitochondrial dysfunction and mitochondrial dynamics after subarachnoid hemorrhage. Food & Function, 9 (12): (6349-6359). [PMID:30452052] |
16. Xu Renjie, Peng Ying, Wang Mengyue, Li Xiaobo. (2019) Intestinal Absorption of Isoalantolactone and Alantolactone, Two Sesquiterpene Lactones from Radix Inulae, Using Caco-2 Cells. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 44 (2): (295-303). [PMID:30209793] |
17. Nani Wang, Qiaoyan Zhang, Hailiang Xin, Dan Shou, Luping Qin. (2017) Osteoblast cell membrane chromatography coupled with liquid chromatography and time-of-flight mass spectrometry for screening specific active components from traditional Chinese medicines. JOURNAL OF SEPARATION SCIENCE, 40 (22): (4311-4319). [PMID:28884956] |
18. Yixian Liu, Bingjie Liu, Yan Zhang, Youmei Peng, Chenzheng Huang, Ning Wang, Jinhua Jiang, Qingduan Wang, Junbiao Chang. (2017) Intestinal absorption mechanisms of 2′-deoxy-2′-β-fluoro-4′-azidocytidine, a cytidine analog for AIDS treatment, and its interaction with P-glycoprotein, multidrug resistance-associated protein 2 and breast cancer resistance protein. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 105 (150). [PMID:28487144] |
19. Chen Ying, Huang Liyong, Zhang Huiyong, Diao Xiling, Zhao Shuyang, Zhou Wenke. (2017) Reduction in Autophagy by (-)-Epigallocatechin-3-Gallate (EGCG): a Potential Mechanism of Prevention of Mitochondrial Dysfunction After Subarachnoid Hemorrhage. MOLECULAR NEUROBIOLOGY, 54 (1): (392-405). [PMID:26742518] |
20. Qing Wang, Yao Long, Lin Yao, Li Xu, Zhi-Guo Shi, Lanying Xu. (2016) Preparation, characterization and application of a reversed phase liquid chromatography/hydrophilic interaction chromatography mixed-mode C18-DTT stationary phase. TALANTA, 146 (442). [PMID:26695288] |
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22. Wenjing Li, Xinru Li, Yajie Gao, Yanxia Zhou, Shujin Ma, Yong Zhao, Jinwen Li, Yan Liu, Xinglin Wang, Dongdong Yin. (2014) Inhibition Mechanism of P-glycoprotein Mediated Efflux by mPEG-PLA and Influence of PLA Chain Length on P-glycoprotein Inhibition Activity. MOLECULAR PHARMACEUTICS, 11 (1): (71–80). [PMID:24256068] |
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25. Gao J, Aisa HA.. (2017) Terpenoids from Euphorbia soongarica and Their Multidrug Resistance Reversal Activity.. J Nat Prod, 80 (6): (1767-1775). [PMID:28590124] |
1. Jie Huang, Xiao Tang, Ziqiong Yang, Jianqiu Chen, Kun Wang, Chengnan Shi, Zihan Liu, Ming Wu, Qian Du. (2024) Enhancing oral delivery and anticancer efficacy of 7-ethyl-10-hydroxycamptothecin through self-assembled micelles of deoxycholic acid grafted N'-nonyl-trimethyl chitosan. COLLOIDS AND SURFACES B-BIOINTERFACES, 234 (113736). [PMID:38215603] |
2. Yu Wang, Yao Yu, Yi-Ping Hou, Xue-Wei Mao, Zong-Liang Liu, Jian Cui, Bi Wang, Shu Xu, Yi-Yun Qian, Yan-Qin Jiang, Min Wei, Ping-Ping Song. (2023) Crucial Role of the Ca2+/CN Signaling Pathway in the Antifungal Activity of Seselin against Botrytis cinerea. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (25): (9772–9781). [PMID:37313981] |
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