Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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V303890-100mg | 100mg | In stock | $93.90 | |
V303890-250mg | 250mg | In stock | $153.90 | |
V303890-1g | 1g | In stock | $383.90 |
Synonyms | VERAPAMIL | 52-53-9 | Iproveratril | Dilacoran | Vasolan | Isoptimo | Isoptin | Verapamilo | Verapamilum | Falicard | Finoptin | Calan | Lekoptin | Isoptine | D-365 | Verapamilum [INN-Latin] | Verapamilo [INN-Spanish] | Isotopin | Securon | Calcan | Tarka | CP-16533-1 | dl-Verapamil | (+/-)-VERAPAMIL |
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Specifications & Purity | Moligand™, ≥98% |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | CHANNEL BLOCKER, GATING INHIBITOR, INHIBITOR |
Mechanism of action | Channel blocker of Ca v1.1;Channel blocker of Ca v1.2;Gating inhibitor of Ca v1.2;Channel blocker of Ca v1.3;Channel blocker of Ca v1.4;Inhibitor of CYP3A4;Gating inhibitor of K ir3.2;Channel blocker of K v1.7;Channel blocker of K v1.8;Channel blocker of |
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IUPAC Name | 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile |
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INCHI | InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3 |
InChi Key | SGTNSNPWRIOYBX-UHFFFAOYSA-N |
Canonical SMILES | CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC |
Isomeric SMILES | CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC |
PubChem CID | 2520 |
Molecular Weight | 454.6 |
PubChem CID | 2520 |
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ChEBI | CHEBI:9948 |
CAS Registry No. | 52-53-9 |
Wikipedia | Verapamil |
DrugBank Ligand | DB00661 |
BindingDB Ligand | 50279753 |
ChEMBL Ligand | CHEMBL6966 |
PEP | verapamil |
Antibiotic DB | 1429 |
DrugCentral Ligand | 2815 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
E2410255 | Certificate of Analysis | May 17, 2024 | V303890 |
E2410374 | Certificate of Analysis | May 17, 2024 | V303890 |
D2426085 | Certificate of Analysis | Jul 14, 2023 | V303890 |
F23271471 | Certificate of Analysis | Jul 14, 2023 | V303890 |
F23271472 | Certificate of Analysis | Jul 14, 2023 | V303890 |
F23271473 | Certificate of Analysis | Jul 14, 2023 | V303890 |
F23271475 | Certificate of Analysis | Jul 14, 2023 | V303890 |
F23271479 | Certificate of Analysis | Jul 14, 2023 | V303890 |
F23271480 | Certificate of Analysis | Jul 14, 2023 | V303890 |
C2219461 | Certificate of Analysis | May 30, 2022 | V303890 |
C2219462 | Certificate of Analysis | May 30, 2022 | V303890 |
C2219467 | Certificate of Analysis | May 30, 2022 | V303890 |
D2318961 | Certificate of Analysis | May 30, 2022 | V303890 |
Boil Point(°C) | 243-246 ºC |
---|---|
Melt Point(°C) | 25°C |
Pictogram(s) | GHS06 |
---|---|
Signal | Danger |
Hazard Statements | H301:Toxic if swallowed H311:Toxic in contact with skin H331:Toxic if inhaled |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P361+P364:Take off immediately all contaminated clothing and wash it before reuse. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P316:Get emergency medical help immediately. |
1. Jie Huang, Xiao Tang, Ziqiong Yang, Jianqiu Chen, Kun Wang, Chengnan Shi, Zihan Liu, Ming Wu, Qian Du. (2024) Enhancing oral delivery and anticancer efficacy of 7-ethyl-10-hydroxycamptothecin through self-assembled micelles of deoxycholic acid grafted N'-nonyl-trimethyl chitosan. COLLOIDS AND SURFACES B-BIOINTERFACES, 234 (113736). [PMID:38215603] |
2. Yu Wang, Yao Yu, Yi-Ping Hou, Xue-Wei Mao, Zong-Liang Liu, Jian Cui, Bi Wang, Shu Xu, Yi-Yun Qian, Yan-Qin Jiang, Min Wei, Ping-Ping Song. (2023) Crucial Role of the Ca2+/CN Signaling Pathway in the Antifungal Activity of Seselin against Botrytis cinerea. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (25): (9772–9781). [PMID:37313981] |
3. Lan Tang, Kaijuan Huang, Wenhui Jiang, Lulu Fu, Ran Zhang, Liting Shen, Zhimin Ou, Ye Huang, Zhenhai Zhang. (2023) Exploration of the inhibition action of TPGS on tumor cells and its combined use with chemotherapy drugs. DRUG DELIVERY, 30 (1): (2183830). [PMID:36852689] |
4. Bin Jiao, Huimin Ye, Xinwei Liu, Jiexun Bu, Junhan Wu, Wenpeng Zhang, Yunfeng Zhang, Zheng Ouyang. (2021) Handheld Mass Spectrometer with Intelligent Adaptability for On-Site and Point-of-Care Analysis. ANALYTICAL CHEMISTRY, 93 (47): (15607–15616). [PMID:34780167] |
5. Yuqin Zhou, Weitong Hu, Xiangli Zhang, Yi Wang, Wenya Zhuang, Fengzhi Li, Qingyong Li. (2021) Cellular Uptake and Transport Characteristics of FL118 Derivatives in Caco-2 Cell Monolayers. CHEMICAL & PHARMACEUTICAL BULLETIN, 69 (11): (1054-1060). [PMID:34719586] |
6. Liyun Ma,Simin Liu,Qing Wang,Lin Yao,Li Xu. (2015-02-03) Cucurbit(6)uril immobilized on silica: a novel high-performance liquid chromatographic stationary phase.. Journal of separation science, 38 ((7)): (1082-1089). [PMID:25641573] |
7. Qing Lin,Li-qin Ling,Ling Guo,Tao Gong,Xun Sun,Zhi-rong Zhang. (2015-06-09) Intestinal absorption characteristics of imperialine: in vitro and in situ assessments.. Acta pharmacologica Sinica, 36 ((7)): (863-873). [PMID:26051111] |
8. Gao J, Aisa HA.. (2017) Terpenoids from Euphorbia soongarica and Their Multidrug Resistance Reversal Activity.. J Nat Prod, 80 (6): (1767-1775). [PMID:28590124] |
1. Jie Huang, Xiao Tang, Ziqiong Yang, Jianqiu Chen, Kun Wang, Chengnan Shi, Zihan Liu, Ming Wu, Qian Du. (2024) Enhancing oral delivery and anticancer efficacy of 7-ethyl-10-hydroxycamptothecin through self-assembled micelles of deoxycholic acid grafted N'-nonyl-trimethyl chitosan. COLLOIDS AND SURFACES B-BIOINTERFACES, 234 (113736). [PMID:38215603] |
2. Yu Wang, Yao Yu, Yi-Ping Hou, Xue-Wei Mao, Zong-Liang Liu, Jian Cui, Bi Wang, Shu Xu, Yi-Yun Qian, Yan-Qin Jiang, Min Wei, Ping-Ping Song. (2023) Crucial Role of the Ca2+/CN Signaling Pathway in the Antifungal Activity of Seselin against Botrytis cinerea. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (25): (9772–9781). [PMID:37313981] |
3. Lan Tang, Kaijuan Huang, Wenhui Jiang, Lulu Fu, Ran Zhang, Liting Shen, Zhimin Ou, Ye Huang, Zhenhai Zhang. (2023) Exploration of the inhibition action of TPGS on tumor cells and its combined use with chemotherapy drugs. DRUG DELIVERY, 30 (1): (2183830). [PMID:36852689] |
4. Bin Jiao, Huimin Ye, Xinwei Liu, Jiexun Bu, Junhan Wu, Wenpeng Zhang, Yunfeng Zhang, Zheng Ouyang. (2021) Handheld Mass Spectrometer with Intelligent Adaptability for On-Site and Point-of-Care Analysis. ANALYTICAL CHEMISTRY, 93 (47): (15607–15616). [PMID:34780167] |
5. Yuqin Zhou, Weitong Hu, Xiangli Zhang, Yi Wang, Wenya Zhuang, Fengzhi Li, Qingyong Li. (2021) Cellular Uptake and Transport Characteristics of FL118 Derivatives in Caco-2 Cell Monolayers. CHEMICAL & PHARMACEUTICAL BULLETIN, 69 (11): (1054-1060). [PMID:34719586] |
6. Liyun Ma,Simin Liu,Qing Wang,Lin Yao,Li Xu. (2015-02-03) Cucurbit(6)uril immobilized on silica: a novel high-performance liquid chromatographic stationary phase.. Journal of separation science, 38 ((7)): (1082-1089). [PMID:25641573] |
7. Qing Lin,Li-qin Ling,Ling Guo,Tao Gong,Xun Sun,Zhi-rong Zhang. (2015-06-09) Intestinal absorption characteristics of imperialine: in vitro and in situ assessments.. Acta pharmacologica Sinica, 36 ((7)): (863-873). [PMID:26051111] |
8. Gao J, Aisa HA.. (2017) Terpenoids from Euphorbia soongarica and Their Multidrug Resistance Reversal Activity.. J Nat Prod, 80 (6): (1767-1775). [PMID:28590124] |