Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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V111249-1g | 1g | In stock | $58.90 | |
V111249-5g | 5g | In stock | $105.90 | |
V111249-25g | 25g | In stock | $477.90 | |
V111249-100g | 100g | In stock | $1,717.90 |
L-type Ca 2+ channel blocker
Synonyms | Geangin | Novapamyl LP | Verpamil | Manidon | Verapamil NM Pharma | Berkatens | Veracaps SR | Verapamil AL | Apo-Verap | Civicor | Hexasoptin | Inselon | Isoptino | Jenapamil | Lodixal | Quasar | Cordilox | Nu-Verap | Dilacoran HTA | Vasomil | Verapamil H |
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Specifications & Purity | ≥99% |
Biochemical and Physiological Mechanisms | Description:IC50 Value: 0.246 ±0.013 (Cardiac L-Type Calcium Channel) [1]Verapamil is an L-type calcium channel blocker of thephenylalkylamine class. It has been used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, and most r |
Storage Temp | Store at 2-8°C,Protected from light |
Shipped In | Wet ice |
Action Type | BLOCKER |
Mechanism of action | Voltage-gated L-type calcium channel blocker |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information . Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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Pubchem Sid | 488183621 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488183621 |
IUPAC Name | 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile;hydrochloride |
INCHI | InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H |
InChi Key | DOQPXTMNIUCOSY-UHFFFAOYSA-N |
Canonical SMILES | CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl |
Isomeric SMILES | CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl |
WGK Germany | 3 |
RTECS | YV8320000 |
PubChem CID | 62969 |
UN Number | 2811 |
Molecular Weight | 491.06 |
Beilstein | 3647093 |
Reaxy-Rn | 3647093 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
G2417467 | Certificate of Analysis | Jun 14, 2024 | V111249 |
F23061595 | Certificate of Analysis | May 24, 2023 | V111249 |
F23061637 | Certificate of Analysis | May 24, 2023 | V111249 |
F23061649 | Certificate of Analysis | May 24, 2023 | V111249 |
D23231220 | Certificate of Analysis | Dec 01, 2022 | V111249 |
D23231221 | Certificate of Analysis | Dec 01, 2022 | V111249 |
D23231222 | Certificate of Analysis | Dec 01, 2022 | V111249 |
D23231227 | Certificate of Analysis | Dec 01, 2022 | V111249 |
D23231228 | Certificate of Analysis | Dec 01, 2022 | V111249 |
D23231229 | Certificate of Analysis | Dec 01, 2022 | V111249 |
D23231230 | Certificate of Analysis | Dec 01, 2022 | V111249 |
D23231231 | Certificate of Analysis | Dec 01, 2022 | V111249 |
G2216547 | Certificate of Analysis | Jun 12, 2022 | V111249 |
G2216549 | Certificate of Analysis | Jun 12, 2022 | V111249 |
G2216582 | Certificate of Analysis | Jun 12, 2022 | V111249 |
Solubility | Slightly soluble in water; Soluble in methanol and ethanol; Insoluble in ether |
---|---|
Sensitivity | light sensitive |
Melt Point(°C) | 140-147.0°C |
Pictogram(s) | GHS06 |
---|---|
Signal | Danger |
Hazard Statements | H301:Toxic if swallowed H311:Toxic in contact with skin H331:Toxic if inhaled |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER/doctor/... P311:Call a POISON CENTER or doctor/... |
WGK Germany | 3 |
RTECS | YV8320000 |
Reaxy-Rn | 3647093 |
Merck Index | 9950 |
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2. Ji Feng, Wenlong Luo, Wentao He, Xingxing Ai, Pingan Song. (2023) Bio-derived phosphorous-nitrogen-silicon decorated halloysite nanotube towards enhancing flame retardant, UV-blocking and mechanical properties of poly(lactic acid). POLYMER DEGRADATION AND STABILITY, 217 (110509). [PMID:] |
3. Yang Zhao, Luyue Zhang, Shiyu Zhang, Xing Zheng, Mingzhu Zheng, Jingsheng Liu. (2023) Maleic anhydride-modified xylanase and its application to the clarification of fruits juices. Food Chemistry-X, (100830). [PMID:37780259] |
4. Yufeng Chen, Guobin Xia, Chunfeng Wang, Huawei Wu, Xiaogang Xu, Genxiang Mao, Jiong Wu, Zhenlei Zhao. (2023) Impact of dietary plant flavonoids on 7,8-dihydroxyflavone transepithelial transport in human intestinal Caco-2 cells. Food Science & Nutrition, [PMID:37970375] |
5. Jiezhou Pan, Haotian Liao, Guidong Gong, Yunxiang He, Qin Wang, Lang Qin, Yaoyao Zhang, Hirotaka Ejima, Blaise L. Tardy, Joseph J. Richardson, Jiaojiao Shang, Orlando J. Rojas, Yong Zeng, Junling Guo. (2023) Supramolecular nanoarchitectonics of phenolic-based nanofiller for controlled diffusion of versatile drugs in hydrogels. JOURNAL OF CONTROLLED RELEASE, 360 (433). [PMID:37422124] |
6. Yang Liu, Chuanlei Zhang, Yanhui Kong, Huiyu Liu, Cheng Chen, Wenyu Gao, Xiaowei Xi, Hui Yang, Linhong Deng. (2023) Preparation and Characterization of a Photo-Crosslinked Methacryloyl-Collagen Composite Film to Promote Corneal Nerve Regeneration via Surface Grafting of Taurine Molecules. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (14): (11248). [PMID:37511012] |
7. Huijing Chen, Mingze Fu, Yi Zhang, Chenyang Ma, Jianquan Kan. (2023) Effect of temperature during acetylation and heat moisture treatment on the structural and physicochemical properties and application of wheat starch. FOOD HYDROCOLLOIDS, 144 (109036). [PMID:] |
8. Chengde Liu, Wanting Du, Luyao Jiang, Yizheng Li, Cheng Liu, Xigao Jian. (2023) Enhanced antibacterial and adhesive properties of chitosan/gelatin hydrogel containing berberine hydrochloride and prepolymerized gallic acid exhibiting aggregation-induced emission. POLYMER ENGINEERING AND SCIENCE, 63 (8): (2596-2612). [PMID:] |
9. Wen Sun, Tingwu Liu, Xieli Zhang, Xu Zhang, Qiuyan Yan, Jinghua Yin, Shifang Luan. (2023) Aquatic Diatoms-Inspired Universal Adhesive Coacervates Triggered by Water. Advanced Healthcare Materials, 12 (24): (2300669). [PMID:37314335] |
10. Xiangyu Wang, Mingwei Zhao, Xuhao Wang, Peng Liu, Mengyao Fan, Xiaowei Yan, Zhenfeng Ma, Yanfang Zhang, Caili Dai. (2023) Synergistic effect of dual hydrogen-donor deep eutectic solvent for performance improvement of fracturing-oil expulsion fluids. CHEMICAL ENGINEERING JOURNAL, 468 (143728). [PMID:] |
11. Lu Liu, Baojie Liu, Xiangyu Li, Zenglin Wang, Linlin Mu, Chengrong Qin, Chen Liang, Caoxing Huang, Shuangquan Yao. (2023) Mannitol assisted oxalic acid pretreatment of poplar for the deconstruction and separation of hemicellulose. INDUSTRIAL CROPS AND PRODUCTS, 200 (116811). [PMID:] |
12. Shuang Chen, Yihui Wang, Yan Shi. (2023) Synergistic Fertilizers Improved Chemical Properties of Soil in Wheat (Triticum aestivum L.) Field. COMMUNICATIONS IN SOIL SCIENCE AND PLANT ANALYSIS, [PMID:] |
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17. Huanhuan Wang, Fangling Wu, Xinhua Dai, Xiang Fang, Chuan-Fan Ding. (2023) Rapid discrimination of enantiomers by ion mobility mass spectrometry and chemical theoretical calculation: Chiral mandelic acid and its derivatives. ANALYTICA CHIMICA ACTA, 1239 (340725). [PMID:36628725] |
18. Dong Rong, Zhang Yougang, Chen Shanjun, Wang Huan, Hu Kaiqing, Zhao Huanxin, Tian Qingping, Zeng Kewu, Wang Songsong, Han Liwen. (2022) Identification of key pharmacodynamic markers of American ginseng against heart failure based on metabolomics and zebrafish model. Frontiers in Pharmacology, 13 [PMID:36313322] |
19. Qiong Xiao, Mingze Ma, Jun Chen, Yonghui Zhang, Fuquan Chen, Huifen Weng, Anfeng Xiao. (2022) Preparation of macroporous rigid agarose microspheres by pre-crosslinking with cyclic anhydride. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 222 (41). [PMID:36156340] |
20. Wang Yiran, Shi Jihua, Dai Dapeng, Cai Jianping, Wang Shuanghu, Hong Yun, Zhou Shan, Zhao Fangling, Zhou Quan, Geng Peiwu, Zhou Yunfang, Xu Xue, Luo Qingfeng. (2022) Evaluation of commonly used cardiovascular drugs in inhibiting vonoprazan metabolism in vitro and in vivo. Frontiers in Pharmacology, 13 [PMID:36052128] |
21. Junxian Xie, Jun Xu, Zhaohui Zhang, Bin Wang, Shiyun Zhu, Jun Li, Kefu Chen. (2023) New ternary deep eutectic solvents with cycle performance for efficient pretreated radiata pine forming to lignin containing cellulose nanofibrils. CHEMICAL ENGINEERING JOURNAL, 451 (138591). [PMID:] |
22. Peiqi Yuan, Yilun Luo, Lie Ma. (2022) NIR-triggered hydrogel with dynamic stiffness via ion chelation to modulate macrophage phenotypes. JOURNAL OF POLYMER SCIENCE, 60 (23): (3176-3185). [PMID:] |
23. Gongrui Wang, Wentao Wang, Xiaoyue He, Jie Li, Lai Yu, Bo Peng, Rong Liu, Suyuan Zeng, Genqiang Zhang. (2022) Tailoring Nitrogen Species in Disk-Like Carbon Anode Towards Superior Potassium Ion Storage. Small, 18 (30): (2203288). [PMID:35780484] |
24. Wenguang Yu, Xuefeng Gao, Zhicheng Yuan, Haihui Liu, Xuechen Wang, Xingxiang Zhang. (2022) Facial fabrication of few-layer functionalized graphene with sole functional group through Diels–Alder reaction by ball milling. RSC Advances, 12 (28): (17990-18003). [PMID:35765334] |
25. Shuzhen Dou, Zhongshun Wang, Qiye Chen, Nan Lu. (2022) One-step fabrication of high-density Si nanotips as SALDI-MS substrate for highly sensitive detection. SENSORS AND ACTUATORS B-CHEMICAL, 359 (131578). [PMID:] |
26. Siying Ye, Yonghui Zhang, Jun Chen, Fuquan Chen, Huifen Weng, Qiong Xiao, Anfeng Xiao. (2022) Synthesis and properties of maleic anhydride-modified agar with reversibly controlled gel strength. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 201 (364). [PMID:34998880] |
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1. Šrámek J et al.. (2021) Calcium channel blockers do not protect against saturated fatty acid-induced ER stress and apoptosis in human pancreatic ß-cells.. Nutr Metab (Lond), 18 (74). [PMID:34274001] |
2. Kobuszewska A et al.. (2017) Heart-on-a-Chip: An Investigation of the Influence of Static and Perfusion Conditions on Cardiac (H9C2) Cell Proliferation, Morphology, and Alignment.. SLAS Technol, 22 (5): (536-546). [PMID:28430559] |
3. Silswal N et al.. (2011) Phosphatidylinositol 3,5-bisphosphate increases intracellular free Ca2+ in arterial smooth muscle cells and elicits vasocontraction.. Am J Physiol Heart Circ Physiol, 300 (6): (H2016-26). [PMID:21421826] |
4. Lyu Yingren, Ji Hairui, Ji Xingxiang, Tian Zhongjian, Zhang Fengshan. (2023) A sustainable valorization of Kenaf stalk by maleic acid pretreatment towards lignin-based sunscreens preparation and papermaking. CELLULOSE, 30 (15): (9725-9739). [PMID:10601354] |
5. Ji Feng, Wenlong Luo, Wentao He, Xingxing Ai, Pingan Song. (2023) Bio-derived phosphorous-nitrogen-silicon decorated halloysite nanotube towards enhancing flame retardant, UV-blocking and mechanical properties of poly(lactic acid). POLYMER DEGRADATION AND STABILITY, 217 (110509). [PMID:] |
6. Yang Zhao, Luyue Zhang, Shiyu Zhang, Xing Zheng, Mingzhu Zheng, Jingsheng Liu. (2023) Maleic anhydride-modified xylanase and its application to the clarification of fruits juices. Food Chemistry-X, (100830). [PMID:37780259] |
7. Yufeng Chen, Guobin Xia, Chunfeng Wang, Huawei Wu, Xiaogang Xu, Genxiang Mao, Jiong Wu, Zhenlei Zhao. (2023) Impact of dietary plant flavonoids on 7,8-dihydroxyflavone transepithelial transport in human intestinal Caco-2 cells. Food Science & Nutrition, [PMID:37970375] |
8. Jiezhou Pan, Haotian Liao, Guidong Gong, Yunxiang He, Qin Wang, Lang Qin, Yaoyao Zhang, Hirotaka Ejima, Blaise L. Tardy, Joseph J. Richardson, Jiaojiao Shang, Orlando J. Rojas, Yong Zeng, Junling Guo. (2023) Supramolecular nanoarchitectonics of phenolic-based nanofiller for controlled diffusion of versatile drugs in hydrogels. JOURNAL OF CONTROLLED RELEASE, 360 (433). [PMID:37422124] |
9. Yang Liu, Chuanlei Zhang, Yanhui Kong, Huiyu Liu, Cheng Chen, Wenyu Gao, Xiaowei Xi, Hui Yang, Linhong Deng. (2023) Preparation and Characterization of a Photo-Crosslinked Methacryloyl-Collagen Composite Film to Promote Corneal Nerve Regeneration via Surface Grafting of Taurine Molecules. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (14): (11248). [PMID:37511012] |
10. Huijing Chen, Mingze Fu, Yi Zhang, Chenyang Ma, Jianquan Kan. (2023) Effect of temperature during acetylation and heat moisture treatment on the structural and physicochemical properties and application of wheat starch. FOOD HYDROCOLLOIDS, 144 (109036). [PMID:] |
11. Chengde Liu, Wanting Du, Luyao Jiang, Yizheng Li, Cheng Liu, Xigao Jian. (2023) Enhanced antibacterial and adhesive properties of chitosan/gelatin hydrogel containing berberine hydrochloride and prepolymerized gallic acid exhibiting aggregation-induced emission. POLYMER ENGINEERING AND SCIENCE, 63 (8): (2596-2612). [PMID:] |
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