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Veratridine - ≥97%, high purity , CAS No.71-62-5, Activator of Na v1.1;Activator of Na v1.2;Activator of Na v1.3;Activator of Na v1.4;Activator of Na v1.5;Activator of Na v1.6;Activator of Na v1.7;Activator of Na v1.8

Specifications & Purity: ≥97%

CAS#: 71-62-5
Formula: C₃₆H₅₁NO₁₁
Molecular Weight: 673.8
PubChem CID: 6280

Item Number

V275475

Grouped product items
SKU	Size	Availability	Price	Qty
V275475-5mg	5mg	In stock	$117.90
V275475-10mg	10mg	In stock	$187.90

Na + channel opener

View related series

Nav1.1 Activator Nav1.2 Activator Nav1.3 Activator Nav1.4 Activator Nav1.5 Activator Nav1.6 Activator Nav1.7 Activator Nav1.8 Activator

Basic Description

Synonyms	veratridine\|71-62-5\|3-Veratroylveracevine\|veratridin\|3-Veratroylveracevin\|CHEBI:28051\|M4BNP1KR7W\|Veratrine (amorphous)\|NIOSH/FL5630000\|1,2,4-triazolo[4,3-a]pyridin-3-ol\|FL56300000\|NSC7524\|4,9-Epoxycevane-3-beta,4-beta,12,14,16-beta,17,20-heptol 3-veratrat
Specifications & Purity	≥97%
Storage Temp	Store at -20°C,Desiccated
Shipped In	Dry ice
Action Type	ACTIVATOR
Mechanism of action	Activator of Na v1.1;Activator of Na v1.2;Activator of Na v1.3;Activator of Na v1.4;Activator of Na v1.5;Activator of Na v1.6;Activator of Na v1.7;Activator of Na v1.8

Associated Targets

SCN2A Tclin Sodium channel protein type 2 subunit alpha 1 Activities

Discover Target: SCN2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN5A Tclin Sodium channel protein type 5 subunit alpha 1 Activities

Discover Target: SCN5A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN10A Tclin Sodium channel protein type 10 subunit alpha 0 Activities

Discover Target: SCN10A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN3A Tclin Sodium channel protein type 3 subunit alpha 0 Activities

Discover Target: SCN3A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN9A Tclin Sodium channel protein type 9 subunit alpha 0 Activities

Discover Target: SCN9A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN4A Tclin Sodium channel protein type 4 subunit alpha 0 Activities

Discover Target: SCN4A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN1A Tclin Sodium channel protein type 1 subunit alpha 0 Activities

Discover Target: SCN1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN8A Tclin Sodium channel protein type 8 subunit alpha 0 Activities

Discover Target: SCN8A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	[(1R,2S,6S,9S,10R,11S,12S,14R,15S,18S,19S,22S,23S,25R)-1,10,11,12,14,23-hexahydroxy-6,10,19-trimethyl-24-oxa-4-azaheptacyclo[12.12.0.02,11.04,9.015,25.018,23.019,25]hexacosan-22-yl] 3,4-dimethoxybenzoate
INCHI	InChI=1S/C36H51NO11/c1-19-6-11-26-31(3,40)35(43)25(17-37(26)16-19)33(42)18-34-24(32(33,41)15-27(35)38)10-9-23-30(34,2)13-12-28(36(23,44)48-34)47-29(39)20-7-8-21(45-4)22(14-20)46-5/h7-8,14,19,23-28,38,40-44H,6,9-13,15-18H2,1-5H3/t19-,23-,24-,25-,26-,27-,28-,30-,31+,32+,33+,34+,35-,36-/m0/s1
InChi Key	FVECELJHCSPHKY-YFUMOZOISA-N
Canonical SMILES	CC1CCC2C(C3(C(CC4(C5CCC6C7(C5(CC4(C3CN2C1)O)OC6(C(CC7)OC(=O)C8=CC(=C(C=C8)OC)OC)O)C)O)O)O)(C)O
Isomeric SMILES	C[C@H]1CC[C@H]2[C@@]([C@]3([C@H](C[C@]4([C@@H]5CC[C@H]6[C@]7([C@]5(C[C@]4([C@@H]3CN2C1)O)O[C@@]6([C@H](CC7)OC(=O)C8=CC(=C(C=C8)OC)OC)O)C)O)O)O)(C)O
PubChem CID	6280
Molecular Weight	673.8

PubChem CID

Wikipedia

ChEMBL Ligand

BindingDB Ligand

CAS Registry No.

ChEBI

Certificates

Certificate of Analysis(COA)

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2 results found

Lot Number	Certificate Type	Date	Item
L2202473	Certificate of Analysis	Sep 18, 2023	V275475
L2202488	Certificate of Analysis	Sep 18, 2023	V275475

Pictogram(s)

GHS06,GHS08,GHS07

Signal

Danger

Hazard Statements

H315,H319,H335,H300,H310,H330,H361

Precautionary Statements

P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P260,P284,P271,P270,P304+P340,P403+P233,P362+P364,P330,P262,P320,P361+P364,P203,P264+P265,P301+P316,P318,P337+P317,P332+P317,P316,P319

References

1. Wei XP et al.. (2022) A novel reticular node in the brainstem synchronizes neonatal mouse crying with breathing.. Neuron, 110 (4): (644-657.e6). [PMID:34998469]
2. Mohammed ZA et al.. (2020) An unbiased and efficient assessment of excitability of sensory neurons for analgesic drug discovery.. Pain, 161 (5): (1100-1108). [PMID:31929383]
3. Zimmermann K et al.. (2013) Analgesic treatment of ciguatoxin-induced cold allodynia.. Pain, 154 (10): (1999-2006). [PMID:23778293]
4. Sousa SR et al.. (2017) Discovery and mode of action of a novel analgesic ß-toxin from the African spider Ceratogyrus darlingi.. PLoS One, 12 (9): (e0182848). [PMID:28880874]
5. Henriques ST et al.. (2016) Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7.. J Biol Chem, 291 (33): (17049-65). [PMID:27311819]
6. Mohammed ZA et al.. (2017) Veratridine produces distinct calcium response profiles in mouse Dorsal Root Ganglia neurons.. Sci Rep, 7 (45221). [PMID:28338073]

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