Basic Description

Synonyms	Vialinin A \| 858134-23-3 \| Terrestrin A \| [3,4-dihydroxy-2,5-bis(4-hydroxyphenyl)-6-(2-phenylacetyl)oxyphenyl] 2-phenylacetate \| 1,1'-(4,4'',5',6'-Tetrahydroxy[1,1':4',1''-terphenyl]-2',3'-diyl) benzeneacetic acid ester \| GTPL8669 \| CHEMBL2012938 \| DTXSID00468621 \| NOJUK
Specifications & Purity	Moligand™, ≥95%
Biochemical and Physiological Mechanisms	Inhibitor of ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T (IsoT) and UCH-L1 deubiquitinating enzyme (DUB) activity (IC50values are 1.5, 5.9 and 22.3μM, respectively). Shows no significant inhibition of UCH-L3, USP2, and USP8 activities. Decr
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of ubiquitin specific peptidase 5

Associated Targets(Human)

USP5 Tchem Ubiquitin carboxyl-terminal hydrolase 5 (1 Activities)

Discover Target: USP5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SENP1 Tchem Sentrin-specific protease 1 (1 Activities)

Discover Target: SENP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CTSB Tchem Cathepsin B (3822 Activities)

Discover Target: CTSB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP5 Tchem Ubiquitin carboxyl-terminal hydrolase 5 (172 Activities)

Discover Target: USP5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

UCHL1 Tchem Ubiquitin carboxyl-terminal hydrolase isozyme L1 (107 Activities)

Discover Target: UCHL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

UCHL3 Tchem Ubiquitin carboxyl-terminal hydrolase isozyme L3 (50 Activities)

Discover Target: UCHL3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP2 Tbio Ubiquitin carboxyl-terminal hydrolase 2 (8818 Activities)

Discover Target: USP2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SENP1 Tchem Sentrin-specific protease 1 (681 Activities)

Discover Target: SENP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP8 Tchem Ubiquitin carboxyl-terminal hydrolase 8 (245 Activities)

Discover Target: USP8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP4 Tchem Ubiquitin carboxyl-terminal hydrolase 4 (12 Activities)

Discover Target: USP4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CAPN2 Tchem Calpain1/2 (15 Activities)

Discover Target: CAPN2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

RBL-2H3 (1162 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mast cell (119 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	[3,4-dihydroxy-2,5-bis(4-hydroxyphenyl)-6-(2-phenylacetyl)oxyphenyl] 2-phenylacetate
INCHI	InChI=1S/C34H26O8/c35-25-15-11-23(12-16-25)29-31(39)32(40)30(24-13-17-26(36)18-14-24)34(42-28(38)20-22-9-5-2-6-10-22)33(29)41-27(37)19-21-7-3-1-4-8-21/h1-18,35-36,39-40H,19-20H2
InChi Key	NOJUKCRPSUMHQQ-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C=C1)CC(=O)OC2=C(C(=C(C(=C2C3=CC=C(C=C3)O)O)O)C4=CC=C(C=C4)O)OC(=O)CC5=CC=CC=C5
Isomeric SMILES	C1=CC=C(C=C1)CC(=O)OC2=C(C(=C(C(=C2C3=CC=C(C=C3)O)O)O)C4=CC=C(C=C4)O)OC(=O)CC5=CC=CC=C5
PubChem CID	11563133
Molecular Weight	562.57

Database links

ChEMBL Ligand	CHEMBL2012938
PubChem CID	11563133
CAS Registry No.	858134-23-3

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
H2308979	Certificate of Analysis	Jul 25, 2023	V287012
H2308984	Certificate of Analysis	Jul 25, 2023	V287012
G2229427	Certificate of Analysis	Jun 20, 2022	V287012
G2229428	Certificate of Analysis	Jun 20, 2022	V287012

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 11.25, Max Conc. mM: 20

References

1. Okada K, Ye YQ, Taniguchi K, Yoshida A, Akiyama T, Yoshioka Y, Onose J, Koshino H, Takahashi S, Yajima A et al.. (2013) Vialinin A is a ubiquitin-specific peptidase inhibitor.. Bioorg Med Chem Lett, 23 (15): (4328-31). [PMID:23791076]

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Vialinin A - 95%, high purity , CAS No.858134-23-3, Inhibitor of ubiquitin specific peptidase 5