Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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V125454-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $53.90 | |
V125454-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $75.90 | |
V125454-1g | 1g | In stock | $1,368.90 | |
V125454-5g | 5g | In stock | $6,156.90 | |
V125454-10g | 10g | In stock | $11,080.90 | |
V125454-25g | 25g | In stock | $24,931.90 | |
V125454-100g | 100g | In stock | $89,754.90 | |
V125454-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $403,895.90 |
Synonyms | (2S)-1-{2-[(3-Hydroxyadamant-1-yl)amino]acetyl}pyrrolidine-2-carbonitrile | (2S)-{((3-Hydroxyadamantan-1-yl)amino)acetyl}pyrrolidine-2-carbonitrile | (2S)-1-{[(3-hydroxyadamant-1-yl)amino]acetyl}pyrrolidine-2-carbonitrile | Vildagliptin | NSC-37389 | s303 |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | Vildagliptin (LAF-237) inhibits DPP?4 with IC50 of 2.3 nM. |
Storage Temp | Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ACTIVATOR, INHIBITOR |
Mechanism of action | Dipeptidyl peptidase IV inhibitor |
Note | 10mg、50mg卖完停产,不再备货 |
Product Description | Vildagliptin is a dipeptidyl peptidase-4 (CD26) inhibitor. CD26 activates serine proteases in immune/inflammatory cells. Vildagliptin also inhibits dipeptidyl-peptidase 8 (DPRP1) and dipeptidyl-peptidase 9 (DPRP2), which have been correlated to T cell activation and immune function, as well as diabetes and cancer regulation. |
ALogP | 0.9 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488195881 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488195881 |
IUPAC Name | (2S)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile |
INCHI | InChI=1S/C17H25N3O2/c18-9-14-2-1-3-20(14)15(21)10-19-16-5-12-4-13(6-16)8-17(22,7-12)11-16/h12-14,19,22H,1-8,10-11H2/t12?,13?,14-,16?,17?/m0/s1 |
InChi Key | SYOKIDBDQMKNDQ-XWTIBIIYSA-N |
Canonical SMILES | C1CC(N(C1)C(=O)CNC23CC4CC(C2)CC(C4)(C3)O)C#N |
Isomeric SMILES | C1C[C@H](N(C1)C(=O)CNC23CC4CC(C2)CC(C4)(C3)O)C#N |
PubChem CID | 6918537 |
Molecular Weight | 303.4 |
PubChem CID | 6918537 |
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CAS Registry No. | 274901-16-5 |
ChEMBL Ligand | CHEMBL142703 |
DrugBank Ligand | DB04876 |
Wikipedia | Vildagliptin |
DrugCentral Ligand | 3642 |
PubChem SID | 488195881 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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H2325792 | Certificate of Analysis | Aug 30, 2023 | V125454 |
H2325785 | Certificate of Analysis | Aug 30, 2023 | V125454 |
H2325742 | Certificate of Analysis | Aug 30, 2023 | V125454 |
E1526066 | Certificate of Analysis | Jan 16, 2023 | V125454 |
F2310608 | Certificate of Analysis | Nov 22, 2022 | V125454 |
F2310610 | Certificate of Analysis | Nov 22, 2022 | V125454 |
F2310611 | Certificate of Analysis | Nov 22, 2022 | V125454 |
F2310612 | Certificate of Analysis | Nov 22, 2022 | V125454 |
F2310613 | Certificate of Analysis | Nov 22, 2022 | V125454 |
F2310614 | Certificate of Analysis | Nov 22, 2022 | V125454 |
F2310615 | Certificate of Analysis | Nov 22, 2022 | V125454 |
F2310617 | Certificate of Analysis | Nov 22, 2022 | V125454 |
F2310618 | Certificate of Analysis | Nov 22, 2022 | V125454 |
F2310607 | Certificate of Analysis | Nov 22, 2022 | V125454 |
F2220044 | Certificate of Analysis | Jun 22, 2022 | V125454 |
G2006118 | Certificate of Analysis | May 12, 2022 | V125454 |
G2006117 | Certificate of Analysis | May 11, 2022 | V125454 |
G2006115 | Certificate of Analysis | May 11, 2022 | V125454 |
K2108682 | Certificate of Analysis | Nov 16, 2021 | V125454 |
F2215112 | Certificate of Analysis | Nov 16, 2021 | V125454 |
Solubility | Soluble in DMSO and Water |
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Sensitivity | Hygroscopic |
Hazard Statements | H413:May cause long lasting harmful effects to aquatic life |
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Precautionary Statements | P273:Avoid release to the environment. P501:Dispose of contents/container to ... |
1. Ma Jie, Li Huan, Hu Xiangnan, Yang Lu, Chen Qi, Hu Congli, Chen Zhihao, Tian Xiaoyan, Yang Yang, Luo Ying, Gan Run, Yang Junqing. (2017) CMD-05, a novel promising clinical anti-diabetic drug candidate, in vivo and vitro studies. Scientific Reports, 7 (1): (1-11). [PMID:28406239] [10.1038/srep46628] |
1. Ma Jie, Li Huan, Hu Xiangnan, Yang Lu, Chen Qi, Hu Congli, Chen Zhihao, Tian Xiaoyan, Yang Yang, Luo Ying, Gan Run, Yang Junqing. (2017) CMD-05, a novel promising clinical anti-diabetic drug candidate, in vivo and vitro studies. Scientific Reports, 7 (1): (1-11). [PMID:28406239] [10.1038/srep46628] |